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A kind of bone biomimetic material reinforced by multi-layer nanofiber fabric and its preparation method

A nanofiber and fabric reinforced technology is applied to the multi-layer nanofiber fabric reinforced bone biomimetic material and its preparation, the field of bone repair or bone replacement material, which can solve the problems of mechanical properties and biocompatibility while satisfying bone repair or replacement. materials and other issues to achieve good osteoinductivity, excellent mechanical properties, and good biocompatibility.

Inactive Publication Date: 2017-07-14
ZHONGYUAN ENGINEERING COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are mainly metals, ceramics and polymers used for bone tissue repair, but none of the existing bone tissue repair materials can meet the requirements of bone repair or replacement materials in terms of mechanical properties and biocompatibility.

Method used

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  • A kind of bone biomimetic material reinforced by multi-layer nanofiber fabric and its preparation method
  • A kind of bone biomimetic material reinforced by multi-layer nanofiber fabric and its preparation method
  • A kind of bone biomimetic material reinforced by multi-layer nanofiber fabric and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A method for bone biomimetic material reinforced by multilayer nanofiber fabric, adopts the following steps:

[0022] (1) Dissolve tussah silk fibroin and polylactic acid in hexafluoroisopropanol at a mass ratio of 1:9, and magnetically stir at room temperature for 2 days to obtain a spinning solution with a mass fraction of 6%;

[0023] (2) Build an electrospinning device according to Figure 1, and add the spinning solution in step (1) to the syringe pump 3 to prepare continuous nanofiber yarns. The electrospinning voltage of the high-voltage generator 5 is 16 kV, the total flow rate of the spinning solution is 0.6 mL / h, the diameter of the metal horn is 10 cm, the vertical distance between the metal horn 4 and the winding device 1 is 40 cm, the nozzle 2 and the metal horn The vertical distance of 4 is 5cm, the horizontal distance between the nozzle and the metal horn is 3cm, the number of nozzles is 4, the inner diameter of the nozzle is 0.36 mm, the solution flow rat...

Embodiment 2

[0029] A method for bone biomimetic material reinforced by multilayer nanofiber fabric, adopts the following steps:

[0030] (1) Dissolve tussah silk fibroin and polylactic acid in hexafluoroisopropanol at a mass ratio of 15:85, and magnetically stir at room temperature for 2 days to obtain a spinning solution with a mass fraction of 7%;

[0031](2) Build an electrospinning device according to Figure 1, and add the spinning solution in step (1) into a syringe pump to prepare continuous nanofiber yarns. The electrospinning voltage was 18 kV, the total flow rate of the spinning solution was 0.8 mL / h, the diameter of the metal horn was 15 cm, the vertical distance between the metal horn and the winding device was 45 cm, the vertical distance between the nozzle and the metal horn was 5 cm, and the distance between the nozzle and the winding device was 45 cm. The horizontal distance of the metal horn is 3 cm, the number of nozzles is 6, the inner diameter of the nozzle is 0.45 mm, ...

Embodiment 3

[0036] A method for bone biomimetic material reinforced by multilayer nanofiber fabric, adopts the following steps:

[0037] (1) Dissolve mulberry silk fibroin and polylactic acid in hexafluoroisopropanol at a mass ratio of 10:90, and stir magnetically at room temperature for 2 days to obtain a spinning solution with a mass fraction of 8%;

[0038] (2) Build an electrospinning device according to Figure 1, and add the spinning solution in step (1) into a syringe pump to prepare continuous nanofiber yarns. The electrospinning voltage was 20 kV, the total flow rate of the spinning solution was 0.9 mL / h, the diameter of the metal horn was 10 cm, the vertical distance between the metal horn and the winding device was 40 cm, the vertical distance between the nozzle and the metal horn was 5 cm, and the distance between the nozzle and the winding device was 40 cm. The horizontal distance of the metal horn is 3 cm, the number of nozzles is 8, the inner diameter of the nozzle is 0.7 mm...

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Abstract

The invention relates to a multi-layer nanofiber fabric reinforced bone biomimetic material and a preparation method thereof. The multi-layer nanofiber fabric reinforced bone biomimetic material is formed by self-assembling of hydroxyapatite on a multi-layer nanofiber fabric template, the mass ratio of organic nanofibers to the inorganic hydroxyapatite is one to one to nine, and the porosity rate is 30%-50%. The particular preparation method comprises the steps that silk fibroin and polylactic acid are dissolved in hexafluoroisopropanol according to different mass ratios to prepare spinning solutions with different mass percentages; nanofiber yarn is prepared through electrostatic spinning, multi-layer nanofiber fabric woven through the weaving technology serves as the template, the fabric is mineralized by utilizing a simulated body fluid biomimetic mineralization method, and the multi-layer nanofiber fabric reinforced bone biomimetic material is obtained. By means of the prepared bone biomimetic material, biomimetization of native bones can be conducted from functions and structures, and the multi-layer nanofiber fabric reinforced bone biomimetic material is a bone biomimetic material which has better application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a multi-layer nanofiber fabric reinforced bone bionic material and a preparation method thereof, which are applied to bone repair or bone substitute materials. Background technique [0002] my country is a large country with a population of 1.3 billion, and it is also a country with a large demand for bone tissue repair and reconstruction materials. At present, there are millions of patients with Kashin-Beck disease caused by rheumatism and rheumatoid; there are 70 million people with an aging population. Patients with osteoporosis; the number of patients with bone defects, fractures and bone loss caused by diseases, traffic accidents and sports trauma is nearly 10 million every year; the number of people who need craniomaxillofacial and limb plastic surgery and cosmetic surgery is also more than ten million . At present, there are mainly metals, ceramics and polymers f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/12A61L27/22A61L27/18D01D5/00D03D15/00D03D11/00D03D13/00D06B3/10D06B15/00
Inventor 何建新韩啟明谭卫琳邵伟力连艳平王利丹崔世忠丁彬
Owner ZHONGYUAN ENGINEERING COLLEGE