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Cold-compression patch with hydrogel as substrate and method for manufacturing cold-compression patch

A technology of hydrogel and cold compress applied in the field of hydrogel-based cold compress and preparation, which can solve the problems of poor biocompatibility and achieve good compatibility, long moisturizing period and no pollution to the environment Effect

Inactive Publication Date: 2015-11-25
TIANJIN ZHUOPU MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Avoid the shortcomings of traditional patches such as poor biocompatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A cold compress using a hydrogel as a matrix, comprising the following parts by weight: the hydrogel comprises the following parts by weight: glycerin: 5 parts, ethyl paraben: 0.1 parts, and aluminum glycolate: 0.2 parts Parts, NP-700: 5 parts, ethanol: 1 part, purified water: 35 parts, K-90: ​​2 parts, XL-10: 1 part, tartaric acid: 0.2 part, light brown: 0.3 part, mint 0.2 part.

[0021] The preparation of a cold compress using hydrogel as a matrix includes the following steps:

[0022] (1) Add 0.1 part of ethyl paraben to 5 parts of glycerin, heat to fully dissolve, and set aside;

[0023] (2) Dissolve 0.2 parts of tartaric acid in an appropriate amount of purified water, and then set aside;

[0024] (3) After fully dissolving 0.3 part of light brown with appropriate amount of purified water, set aside;

[0025] (4) After fully dissolving 2 parts of K-90 and 1 part of XL-10 with an appropriate amount of purified water, stir them evenly and set aside;

[0026] (5) Pour 0.2 parts...

Embodiment 2

[0030] A cold compress using hydrogel as the matrix, comprising the following parts by weight: the hydrogel comprises the following parts by weight: glycerin: 17 parts, ethyl paraben: 0.5 parts, and aluminum glycolate: 1.1 parts. Parts, NP-700: 12 parts, ethanol: 3 parts, purified water: 35-75 parts, K-90: ​​18 parts, XL-10: 5 parts, tartaric acid: 0.6 parts, light brown: 0.7 parts, mint 1.6 parts .

[0031] The preparation of a cold compress using hydrogel as a matrix includes the following steps:

[0032] (1) Add 0.5 parts of ethyl paraben to 17 parts of glycerin, heat to fully dissolve, and set aside;

[0033] (2) After fully dissolving 0.6 parts of tartaric acid in an appropriate amount of purified water, set aside;

[0034] (3) Dissolve 0.7 parts of light brown with appropriate amount of purified water and set aside;

[0035] (4) After fully dissolving 18 parts of K-90 and 5 parts of XL-10 with an appropriate amount of purified water, stir them evenly and set aside;

[0036] (5) P...

Embodiment 3

[0040] A cold compress using hydrogel as a matrix, comprising the following parts by weight: the hydrogel comprises the following parts by weight: glycerin: 30 parts, ethyl paraben: 1 part, aluminum glycolate: 2 parts Parts, NP-700: 20 parts, Ethanol: 5 parts, Purified water: 75 parts, K-90: ​​25 parts, XL-10: 10 parts, Tartaric acid: 1 part, Light brown: 1 part, Mint 3 parts.

[0041] The preparation of a cold compress using hydrogel as a matrix includes the following steps:

[0042] (1) Add 1 part of ethyl paraben to 30 parts of glycerin, heat to fully dissolve, and then set aside;

[0043] (2) After fully dissolving 1 part of tartaric acid in an appropriate amount of purified water, set aside;

[0044] (3) After fully dissolving 1 part of light brown with an appropriate amount of purified water, set aside;

[0045] (4) After fully dissolving 25 parts of K-90 and 10 parts of XL-10 with an appropriate amount of purified water, stir them evenly and set aside;

[0046] (5) Pour 3 parts o...

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Abstract

The invention discloses a cold-compression patch with hydrogel as a substrate and manufacture of the cold-compression patch. The cold-compression patch comprises, by weight, 0.2-3 parts of peppermint, 5-30 parts of glycerin, 0.1-1 part of ethylparaben, 0.2-2 parts of dihydroxyaluminium aminoacetate, 5-20 parts of NP-700, 1-5 parts of ethyl alcohol, 35-75 parts of purified water, 2-25 parts of K-90, 1-10 parts of XL-10, 0.2-1 part of tartaric acid and 0.3-1 part of light brown. The cold-compression patch and the manufacture have the advantages that the hydrogel is mainly selectively made of hydrophilic substrates, and accordingly the manufactured patch is good in skin compatibility, long in moisture retention period, high in perspiration resistance and free of irritation or sensitization, and can be repeatedly stuck to patients; technologies are simple and can be carried out at the normal temperature, the cold-compression patch is convenient to manufacture, harm to operators can be prevented in integral technological procedures, discharge of waste gas, waste water and industrial residues can be prevented in the production and manufacture procedures, and accordingly the cold-compression patch is environmental friendly and safe and is free of environmental pollution.

Description

Technical field [0001] The invention relates to the application and formulation of a hydrogel, in particular to a cold compress using hydrogel as a matrix and a preparation method. Background technique [0002] With the continuous development of the pharmaceutical industry, hydrogels have gradually been widely used in my country’s pharmaceutical market, with large drug loading, good transdermal effects, controllable quality, good air permeability, and low skin irritation. It has become an ideal transdermal drug delivery carrier. Compared with traditional patches, it reduces the use of organic solvents in the production process, thereby avoiding environmental pollution. Overcome the shortcomings of traditional patches. [0003] Hydrogel cold compress patch is a kind of external cooling patch made by using hydrogel to have cold compress effect on human body. The hydrophilic molecular hydrogel quickly absorbs heat and evaporates, thereby quickly reducing the local body surface temper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F7/02A61K9/70A61K36/534A61K47/32A61P29/02
Inventor 周小岳
Owner TIANJIN ZHUOPU MEDICAL EQUIP CO LTD
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