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Application of hydrogen saturated saline

A technology of normal saline and hydrogen, which is applied in the application field of hydrogen-saturated normal saline, to achieve the effect of high injection concentration, good therapeutic advantages, and simple preparation

Active Publication Date: 2018-12-25
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report about the application of hydrogen-saturated saline in the preparation of drugs for stabilizing atherosclerotic plaques.

Method used

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  • Application of hydrogen saturated saline
  • Application of hydrogen saturated saline
  • Application of hydrogen saturated saline

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Experimental program
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Embodiment Construction

[0019] The specific embodiments provided by the present invention will be described in detail below in conjunction with the accompanying drawings.

[0020] Materials and methods

[0021] 1.1 Animals and experimental design

[0022] 80 8-9 week old male LDLR - / - Mice were randomly divided into 5 groups, 16 in each group. They are:

[0023] Negative control group (vehicle group, Control),

[0024] Saturated hydrogen saline low dose group (0.5 ml / kg / d, H 2 -L),

[0025] Saturated hydrogen saline high dose group (5 ml / kg / d, H 2 -H),

[0026] Positive control simvastatin group (5 mg / kg / d, Sim (5)),

[0027] Combined drug group (low dose hydrogen and 2.5 mg / kg / d simvastatin, H 2 -L + Sim(2.5)).

[0028] After one week of adaptive feeding, the rats were given a high-fat (15.8%), high-cholesterol (1.25%) diet and free to drink water. Hydrogen saline was administered intraperitoneally, and simvastatin was administered intragastrically for 28 weeks.

[0029] Preparation of h...

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Abstract

The invention relates to application of hydrogen saturated saline in preparation of drugs for stabilizing atherosclerotic plaques. The application has the advantages that a novel use of the hydrogen saturated saline is provided, and besides a function of inhibiting formation of atherosclerotic plaques, other functions of the hydrogen saturated saline such as stabilizing the atherosclerotic plaques and enabling the atherosclerotic plaques to be rarely vulnerable are disclosed for the first time; the hydrogen saturated saline is simple to prepare, high in injection concentration, convenient to use, free of explosion risk, low in cost and free of side effects; animal experiment results show that the hydrogen saturated saline has great therapeutic advantages, the risk of patients with vulnerable plaques to suffer drug side effects is greatly decreased, and the medical cost is greatly lowered.

Description

technical field [0001] The invention relates to a new application of hydrogen-saturated normal saline, in particular to the application of hydrogen-saturated normal saline in the preparation of medicines for stabilizing atherosclerotic plaques. Background technique [0002] Atherosclerosis (AS) is a nonlinear process with alternating stable and unstable phases, which depends on plaque stability and vulnerability. Compared with the early formation of plaque, the study of plaque stability has attracted more and more attention. The rupture of unstable plaques (vulnerable plaques) in advanced AS is the main cause of acute coronary syndrome, acute cerebral infarction and other cardiovascular and cerebrovascular emergencies. Unstable plaques are characterized by large extracellular lipid pools, thin fibrous caps, and infiltration of macrophages and T lymphocytes. Massive cell apoptosis, especially macrophage apoptosis, is an important factor leading to the formation of vulnerabl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61P9/10
Inventor 宋国华秦树存于杨
Owner TAISHAN MEDICAL UNIV
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