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A polymeric system for release of an active agent

A technology of active agents and polymers, applied in the field of polymerization systems, can solve problems such as limited applicability

Inactive Publication Date: 2015-12-02
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the applicability of this method is limited

Method used

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  • A polymeric system for release of an active agent
  • A polymeric system for release of an active agent
  • A polymeric system for release of an active agent

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Embodiment Construction

[0035] Exemplary, non-limiting embodiments of polymeric systems for releasing active agents will now be disclosed. The polymeric system comprises a first polymeric phase containing an active agent formed in a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein into a polymeric phase having a defined size range. Discrete domains and dispersed in the second polymeric phase.

[0036] The first polymeric phase can act as a reservoir for the active agent, entrapping or releasing the active agent as the concentration of the active agent changes in the second polymeric phase. The active agent in the first polymeric phase can migrate from the first polymeric phase to the second polymeric phase when the active agent is released from the polymeric system. Thus, the concentration of active agent in the second polymeric phase advantageously remains substantially constant over time. This advantageously assists in the sustained...

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Abstract

The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.

Description

technical field [0001] The present invention basically relates to a polymeric system for releasing active agents and a method for its manufacture. The disclosed polymeric systems may be injectable hydrogels for the release of therapeutic agents. Background technique [0002] A hydrogel is a network of cross-linked hydrophilic homo- or hetero-copolymers that has the ability to absorb and retain large quantities of water or biological fluids. Hydrogels are receiving a lot of attention in industry and are in high demand. Natural and synthetic hydrogels have been used as tissue engineering matrices, wound dressings, dermal fillers, and drug delivery devices. In particular, injectable hydrogels have received considerable attention as protein delivery systems that can form stable depots in situ in vivo and release their payloads in a sustained manner. The use of this hydrogel is desirable because it eliminates the need for surgery and allows protein delivery in a clinical setti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50A61K47/30A61K47/48
CPCA61L15/60A61K9/0024A61K38/21A61K38/28A61K38/385A61K47/10A61K47/36A61K47/48A61L15/44A61L27/20A61L27/22A61L27/48A61L27/52A61L27/54A61L31/042A61L31/043A61L31/129A61L31/145A61L31/16A61L2300/622A61L2400/06C08B37/0021C08L5/02C08L71/02A61K47/60A61K38/212A61P43/00C08L5/00A61K47/6903A61K9/0019A61K47/61C08L89/00
Inventor 栗泽元一裵基见李璠
Owner AGENCY FOR SCI TECH & RES
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