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Preparation method for paraffin microballoon

A technology of paraffin wax and microspheres, which is applied in the fields of wax physical treatment, medical science, prosthesis, etc., and can solve the problems of the size and shape of paraffin microspheres, the deformation of paraffin microspheres, and the difficulty of sieving.

Inactive Publication Date: 2015-12-09
SHENZHEN LANDO BIOMATERIALS
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AI Technical Summary

Problems solved by technology

However, the traditional preparation method of paraffin microspheres is usually to directly place the paraffin microspheres at room temperature to air-dry, and then use a standard sieve to sieve the paraffin microspheres. Mutual bonding under storage conditions leads to deformation and bonding of paraffin microspheres, making it difficult to sieve, resulting in difficulty in controlling the size and shape of the prepared paraffin microspheres

Method used

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  • Preparation method for paraffin microballoon
  • Preparation method for paraffin microballoon
  • Preparation method for paraffin microballoon

Examples

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preparation example Construction

[0027] like figure 1 The preparation method of the paraffin microspheres shown comprises the following steps:

[0028] S10. According to the volume ratio of the solid paraffin to the polyvinyl alcohol solution being 2 to 4:5, the liquid paraffin obtained by melting the solid paraffin is slowly added to the polyvinyl alcohol solution at a temperature of 70° C. to 90° C. After stirring, it forms Oil-to-water emulsion.

[0029] The mass percentage content of the solute in the polyvinyl alcohol solution is 0.5% to 5%.

[0030] The temperature of the liquid paraffin obtained after the solid paraffin is melted is 50°C to 200°C.

[0031] S20. Pour the oil-water emulsion obtained in S10 into ice brine at a temperature of -20°C to 10°C, so that the paraffin droplets in the oil-water emulsion are rapidly solidified to obtain a mixture.

[0032] The solute of the ice brine is selected from at least one of sodium chloride, potassium chloride, magnesium chloride and calcium chloride.

...

Embodiment 1

[0050] Put 160 mL of solid paraffin into a beaker and heat it to melt to obtain liquid paraffin with a temperature of 50°C.

[0051] 200 mL of 0.5% polyvinyl alcohol solution was prepared, heated and stirred to 75°C.

[0052] All the above-mentioned liquid paraffin was added to 200 mL of polyvinyl alcohol solution at a slow speed, and an oil-water emulsion was formed after stirring uniformly.

[0053] The above-mentioned oil-water emulsion was poured into ice brine (22.5wt%, NaCl) at a temperature of -20°C, so that the paraffin droplets in the oil-water emulsion were rapidly solidified to form solid paraffin microspheres, thereby obtaining a mixture.

[0054] The mixture was poured into a combination of 10-mesh and 20-mesh standard vibrating sieves for wet sieving, the vibration frequency was 150 rpm, and the purified water was continuously rinsed at 4°C to accelerate the sieving of paraffin microspheres, and simultaneously remove residual dispersant and ice brine.

[0055] T...

Embodiment 2

[0058] Put 80 mL of solid paraffin into a beaker and heat it to melt to obtain liquid paraffin with a temperature of 80°C.

[0059] 200 mL of 2% polyvinyl alcohol solution was prepared, heated and stirred to 86°C.

[0060] All the above-mentioned liquid paraffin was added to 200 mL of polyvinyl alcohol solution at a slow speed, and an oil-water emulsion was formed after stirring uniformly.

[0061] The above-mentioned oil-water emulsion was poured into ice brine (10wt%, NaCl solute) at a temperature of -5°C, so that the paraffin droplets in the oil-water emulsion were rapidly solidified to form solid paraffin microspheres, thereby obtaining a mixture.

[0062] The mixture was poured into a combination of 20-mesh and 50-mesh standard vibrating sieves for wet sieving, the vibration frequency was 600 rpm, and the purified water was continuously rinsed at 4°C to accelerate the sieving of paraffin microspheres, and simultaneously remove residual dispersant and ice brine.

[0063] ...

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Abstract

A disclosed preparation method for a paraffin microballoon comprises the following steps: getting slid paraffin and a polyvinyl alcohol solution according to the volume ratio of 2-4:5, fusing solid paraffin to obtain liquid paraffin, then slowly adding into the polyvinyl alcohol solution, and uniformly stirring to form an oil-water emulsion; pouring the oil-water emulsion into brine ice with the temperature of -20 DEG C to 10 DEG C, so as to obtain a mixture; performing wet sieving on the mixture, and filtering after wet sieving is finished, so as to obtain a paraffin midroballoon; and performing pre-freezing on the paraffin microballoon at -20 DEG C to 10 DEG C, and then performing freeze-drying on the pre-freezed paraffin microballoon and storing. According to the paraffin microballoon preparation method, the paraffin microballoon with a complete spherical structure and uniform dimension is obtained through technological processes of wet sieving, freeze drying and the like, and compared with a conventional paraffin microballoon preparation method, the paraffin microballoon is prevented from being mutually bonded and leading to deformation and bonding because of relatively high room temperature, and thus the size and the shape of the prepared paraffin microballoon are easily controlled.

Description

technical field [0001] The invention relates to the field of new materials, in particular to a preparation method of paraffin microspheres. Background technique [0002] Artificial bone repair materials have good biocompatibility. Compared with traditional bone repair materials such as autologous bone and allogeneic bone, they are favored for their advantages of no immunogenicity, no secondary injury to patients, and a wide range of sources. In order to promote cells and blood vessels to crawl into the material and effectively control the degradation rate of the material, bone repair materials are often prepared as biomimetic porous scaffolds. [0003] There are many methods for preparing porous bone repair scaffolds, generally including organic foam method, porogen method, foaming method, thermally induced phase separation method and microsphere stacking method, among which organic foam method, porogen method and microsphere method. The stacking method is more common. The...

Claims

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Application Information

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IPC IPC(8): C10G73/40A61L27/40A61L27/56
Inventor 潘洋郭远军谭荣伟佘振定
Owner SHENZHEN LANDO BIOMATERIALS
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