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Disodium pamidronate and glucose injection and preparation method thereof

A technology of disodium pamidronate and glucose injection, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of short curative effect maintenance time, curative effect decline, increased fever, etc. question

Active Publication Date: 2015-12-16
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Pamidronate disodium is a bisphosphonate drug, which is a powerful inhibitor of osteoclast activity, can be selectively adsorbed on bone tissue, inhibits the transformation of osteoclast precursors into mature osteoclasts, and reduces bone loss caused by tumors. Destruction, improve bone pain symptoms, easy to use, but the conventional dose is ineffective for some cases or the curative effect maintenance time is short, and the curative effect decreases after multiple courses of treatment (Liao Sihai, Observation on the curative effect of different doses of pamidronate disodium in the treatment of bone metastatic cancer pain[J] , Qiqihar Medical College Journal, 2006 Vol. 27 No. 10)
If a large dose is used, although the curative effect is more significant, it will also increase the toxic and side effects such as fever, nausea, chest pain, chest tightness, dizziness and fatigue.

Method used

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  • Disodium pamidronate and glucose injection and preparation method thereof
  • Disodium pamidronate and glucose injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0017] Embodiment 1-4: Preparation of Pamidronate Disodium Glucose Injection

[0018] The prescription content of table 1 embodiment 1-4 pamidronate disodium glucose injection

[0019] Component content

[0020] Preparation process: add glucose and 2-aminoisobutyric acid to 80% water for injection, stir until dissolved, add 0.1% (W / V) activated carbon for needles, stir well, filter and decarbonize, and adjust the obtained filtrate to pH5 with phosphoric acid .5-6.5, then add Pamidil Disodium Phosphate, stir until Pamidil Disodium Phosphate is completely dissolved, add the remaining amount of water for injection to constant volume, sterilize and filter with a 0.22μm microporous membrane, fill, and sterilize with moist heat to obtain clarity solution.

Embodiment 5

[0021] Example 5: Experimental Study on the Effect of Drugs on Rat Breast Cancer Pain Model with Bone Metastasis

[0022] Take out the cryopreservation tube of breast cancer Walker256 cells, and put it into a 37°C water bath to quickly thaw. Wipe off the water stains on the cryopreservation tube, disinfect the nozzle with 75% alcohol by volume, unscrew the nozzle on the ultra-clean workbench, suck out the cell suspension with a straw, transfer it into a centrifuge tube, and then add an appropriate amount containing 10 RPMI-1640 medium with % fetal bovine serum, pipet to suspend the cells, centrifuge at 1000r / min for 5min, discard the supernatant, rinse with the medium repeatedly once, add an appropriate amount of medium, inoculate into a culture bottle, and place in an incubator After culturing, the medium was replaced once the next day to continue culturing, and the growth was observed. Cells in the logarithmic growth phase were selected and inoculated into the abdominal cavi...

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Abstract

The invention discloses a disodium pamidronate and glucose injection and a preparation method thereof. The injection comprises disodium pamidronate, 2-aminoisobutyric acid and glucose. After 2-aminoisobutyric acid is added to the prescription of the disodium pamidronate and glucose injection, the injection has better palliative treatment function on bone metastasis from advanced tumor, meanwhile, the dose of disodium pamidronate is reduced, the toxic and side effects of the medicine are reduced, and the production cost is reduced.

Description

technical field [0001] The invention belongs to the field of preparation of western medicine injections, and relates to a pamidronate disodium injection, in particular to a pamidronate disodium glucose injection and a preparation method thereof. Background technique [0002] Bone metastases occur in 30%-70% of patients with advanced malignant tumors, and intractable pain occurs, and about 70% of bone metastases occur in the spine, pelvis, hip joints and other weight-bearing parts (Dong Zhiwei, Gu Xianzhi. Clinical Oncology [M ]. Beijing: People's Medical Publishing House, 2002: 371), seriously affecting the quality of life of patients. It is generally believed that the mechanism of pain caused by bone metastases is as follows: tumor metastasis to bone tissue increases the activity of osteoclasts and leads to osteolysis, that is, bone destruction; at the same time, tumor cells can secrete some pain mediators such as prostaglandins and lactic acid, which aggravate pain. . ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/663A61K9/08A61K47/16A61P35/04A61P29/00
Inventor 田舟山林刚
Owner NANJING CHIA TAI TIANQING PHARMA