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A kind of pharmaceutical composition for treating rheumatoid arthritis and its preparation method and application

A rheumatoid and composition technology, which is applied in the direction of drug combination, pharmaceutical formula, active ingredients of hydroxyl compounds, etc., can solve the problems of high toxicity and side effects, no treatment effect of rheumatoid arthritis, etc.

Active Publication Date: 2019-08-06
SUZHOU MAIDIXIAN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent CN101194923A discloses a medicine with the above-mentioned three kinds of Chinese medicinal materials as active ingredients, which specifically uses total terpenes of tripterygium wilfordii, hematoxylin and borneol, and the total terpenes of tripterygium wilfordii contain more triptolide and triptolide Red pigment has relatively large toxic and side effects, and although the drug has an anti-systemic lupus erythematosus effect in a mouse systemic lupus erythematosus model, it has no therapeutic effect on rheumatoid arthritis

Method used

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  • A kind of pharmaceutical composition for treating rheumatoid arthritis and its preparation method and application
  • A kind of pharmaceutical composition for treating rheumatoid arthritis and its preparation method and application
  • A kind of pharmaceutical composition for treating rheumatoid arthritis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Accurately weigh the thick paste of 7.5 grams of ethanol percolation method tripterygium wilfordii extract, the thick paste of 5.25 grams of sumac water extract, 1.5 grams of borneol and 30.75 grams of polyethylene glycol 6000 and place in a heating container, and heat while stirring until obtaining The melt and / or emulsion and / or suspension containing the dry powder of the drug and the base are ready for use. Use a dropping pill machine (TZDW-1 type dropping pill machine produced by Beijing Changzheng Tianmin High-tech Co., Ltd.), adjust the temperature control system of the dropping pill machine to heat the dripper of the dropping pill machine and keep it at 50-90°C, and the condensation column The condensing agent inside is cooled and kept at -5~4°C. When the temperature of the condensing agent in the dropper of the dripping machine and the coagulation column are respectively stable at the above-required temperature state, the emulsion containing the above-mentioned d...

Embodiment 2

[0041] Accurately weigh the thick paste of 4.5 grams of ethanol percolation tripterygium extract, the thick paste of 6.75 grams of sumac water extract, 3.15 grams of borneol and 29.25 grams of polyethylene glycol 6000 and place in a heating container, and heat while stirring until obtaining The melt and / or emulsion and / or suspension containing the dry powder of the drug and the base are ready for use. Use a dropping pill machine (TZDW-1 type dropping pill machine produced by Beijing Changzheng Tianmin High-tech Co., Ltd.), adjust the temperature control system of the dropping pill machine to heat the dripper of the dropping pill machine and keep it at 50-90°C, and the condensation column The condensing agent inside is cooled and kept at -5 ~ 4 ℃. When the temperature of the condensing agent in the dropping head of the dropping pill machine and the coagulation column are respectively stable at the above required temperature state, the molten liquid containing the above-mentioned...

Embodiment 3

[0043] Accurately weigh the thick paste of 9.0 grams of ethanol percolation tripterygium officinalis extract, the thick paste of 3.6 grams of sumac water extract, 0.45 gram of borneol and 31.95 grams of polyethylene glycol 6000 and place in a heating container, and heat while stirring until obtaining The melt and / or emulsion and / or suspension containing the dry powder of the drug and the base are ready for use. Use a dropping pill machine (TZDW-1 type dropping pill machine produced by Beijing Changzheng Tianmin High-tech Co., Ltd.), adjust the temperature control system of the dropping pill machine to heat the dripper of the dropping pill machine and keep it at 50-90°C, and the condensation column The condensing agent inside is cooled and kept at -5 ~ 4 ℃. When the temperature of the condensing agent in the dropping head of the dropping pill machine and the coagulation column are respectively stable at the above required temperature state, the molten liquid containing the above...

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Abstract

The invention discloses a pharmaceutical composition and a preparation method and application thereof. The pharmaceutical composition can be used for treating rheumatoid arthritis, and toxic and side effects are fewer or the toxic and side effects do not exist. The pharmaceutical composition is prepared from, by weight, 10-20 parts of extract of common threewingnut roots, 8-15 parts of aqueous extract of sapanwood and 1-7 parts of borneol. Research shows that the pharmaceutical composition can be used for treating the rheumatoid arthritis, and the toxic and side effects are fewer or the toxic and side effects do not exist.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to a pharmaceutical composition, a preparation method and its application in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis, also known as rheumatoid, is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, and belongs to autoimmune inflammatory disease . The disease is prone to occur in small joints such as hands, wrists, and feet, and recurs in a symmetrical distribution. Rheumatoid arthritis is an autoimmune disease mainly characterized by chronic inflammation of the synovium of the joints, which can cause joint swelling and pain, and then lead to cartilage destruction and narrowing of the joint space, and late joint deformity and eventually various degrees of disability. According to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61K36/37A61P19/02A61P29/00A61K31/045
Inventor 张南钟荣
Owner SUZHOU MAIDIXIAN PHARMA