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Production method for preventing yellowing of plastic bottled sodium chloride injection bottle body

A technology of sodium chloride injection and production method, which is applied in sanitary equipment for toilets, active ingredients of alkali/alkaline earth metal chlorides, chemistry, etc., can solve the problems of increasing manpower and material costs, reduce the probability of pollution, and resist Strong impact force and good bottle sealing effect

Inactive Publication Date: 2015-12-30
GUANGXI YUYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing technology, drugs such as sodium chloride injection are generally produced according to the process steps suggested by the State Food Administration or Pharmacopoeia and other guidance documents. If a drug manufacturer changes the production process for a product that has received approval, it needs to Resubmitting for approval will increase the cost of manpower and material resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A production method for preventing the bottle body of plastic-packed sodium chloride injection from turning yellow, comprising the steps of:

[0024] 1) Weighing: prepare raw and auxiliary materials;

[0025] 2) Concentrated preparation: inject 300L of water for injection into the concentrated preparation tank, start stirring, put sodium chloride into the concentrated preparation tank to fully dissolve the sodium chloride, add 0.02% (w / v) of activated carbon, and clean the carbon adjustment barrel with water for injection There is no carbon stain on the mixing spoon, add the cleaning water to the concentrated tank, boil the liquid medicine and keep it boiling for 10 minutes, and cool the liquid medicine temperature to 70-75°C;

[0026] 3) Dilute formulation: add 2 / 3 of the prepared water to the dilute formulation tank, start stirring, decarbonize and filter the thick formulation through a titanium rod, and then send it to the dilute formulation tank, rinse the concentra...

Embodiment 2

[0033] A production method for preventing the bottle body of plastic-packed sodium chloride injection from turning yellow, comprising the steps of:

[0034] 1) Weighing: prepare raw and auxiliary materials;

[0035] 2) Concentrated preparation: inject 300L of water for injection into the concentrated preparation tank, start stirring, put sodium chloride into the concentrated preparation tank to fully dissolve the sodium chloride, add 0.02% (w / v) of activated carbon, and clean the carbon adjustment barrel with water for injection There is no carbon stain on the mixing spoon, add the cleaning water to the concentrated tank, boil the liquid medicine and keep it boiling for 10 minutes, and cool the liquid medicine temperature to 70-75°C;

[0036] 3) Dilute formulation: add 2 / 3 of the prepared water to the dilute formulation tank, start stirring, decarbonize and filter the thick formulation through a titanium rod, and then send it to the dilute formulation tank, rinse the concentra...

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PUM

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Abstract

The invention discloses a production method for preventing the yellowing of a plastic bottled sodium chloride injection bottle body. The production method adopts the following measures: (1) damage on a bottle blank and a bottle caused by an external force during the production process can be reduced, and the attachment of membrane scraps and fibers on the interior and exterior of a bottle body can be reduced; (2) a sterilizing cabinet water outlet filter device is added, so that the accumulation of the membrane scraps in a sterilizing pipeline and a heat exchanger is reduced; (3) the washing treatment on a sterilizing cabinet is reinforced, the attachment of the yellowing membrane scraps after the high temperature for multiple times can be reduced, the sterilizing cabinet water outlet filter device is washed every day, the sterilizing cabinet is circularly washed every week by adopting 2 percent of NaOH solution, and the sterilizing cabinet of no load is sterilized for one time. After the measures are executed, the yellowing problem of the polypropylene infusion bottled sodium chloride injection bottle body is solved, and the probability of the yellowing bottle is almost zero.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a production method for preventing the bottle body of plastic-packed sodium chloride injection from turning yellow. Background technique [0002] Sodium chloride injection, the main ingredient and its chemical name are: sodium chloride, molecular formula: NaCl molecular weight: 58.44. It is a colorless clear liquid; the taste is slightly salty. For dehydration caused by various reasons, including hypotonic, isotonic and hypertonic dehydration; hypertonic non-ketotic diabetic coma, application of isotonic or hypotonic sodium chloride can correct dehydration and hypertonicity state; hypochloremic metabolic alkalosis; external use of normal saline to wash eyes, wash wounds, etc.; also used in obstetric water sacs to induce labor. [0003] Sodium chloride is an electrolyte replacement drug. Sodium and chlorine are important electrolytes in the body, mainly pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K33/14A61P3/12A61L2/18A61L2/26
Inventor 阮传明吕亚平陈兴华彭洪专陈早邦王敏
Owner GUANGXI YUYUAN PHARMA
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