Traditional Chinese medicine drug granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof

A technology for traditional Chinese medicine granules and lumbar spondylosis, which is applied in the directions of pharmaceutical formulations, non-central analgesics, and non-active ingredients medical preparations, etc. problems, to achieve the effect of high pass rate, reduced dosage, and reduced daily dosage

Active Publication Date: 2015-12-30
JIANGSU HONGHUI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually the dry extract powder of Chinese herbal medicines has fine particle size and strong hygroscopicity, and there will be different degrees of sticking and agglomeration during the granulation process. It is necessary to add 2-3 times the amount of dry extract powder as an auxiliary material to barely make qualified granules. The patient's daily dosage is greatly increased, which is not conducive to the patient's taking
In addition, due to the strong hygroscopicity of the dry extract powder, the generally made traditional Chinese medicine granules also have strong hygroscopicity and poor stability, which is not conducive to the storage and transportation of shaped medicines.

Method used

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  • Traditional Chinese medicine drug granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof
  • Traditional Chinese medicine drug granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof
  • Traditional Chinese medicine drug granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of extract granules: Pass the dry extract powder and diluent dextrin through a 60-mesh sieve, mix, add ethanol as the first wetting agent, wet-mix and granulate for 2 minutes, then add purified water from the second wetting agent, and continue to wet Mix and granulate for 2 minutes to obtain a wet-mixed soft material, granulate the soft material with a swing granulator, and dry it to obtain extract granules;

[0032] Preparation of the volatile oil inclusion compound: Weigh β-cyclodextrin and place it in a ground round bottom flask, add an appropriate amount of water, heat and stir evenly to form a saturated solution; weigh the volatile oil and add an equal weight of absolute ethanol to mix well , Slowly added dropwise to the saturated β-cyclodextrin solution, stirred for 8 hours, cooled to room temperature, refrigerated for 24 hours, suction filtered, washed, vacuum dried, pulverized through an 80-mesh sieve to obtain the volatile oil inclusion compound;

[003...

Embodiment 2

[0036] Preparation of extract granules: Pass the dry extract powder and diluent dextrin through a 60-mesh sieve, mix, add ethanol as the first wetting agent, wet-mix and granulate for 1 minute, then add purified water from the second wetting agent, and continue to wet Mix and granulate for 1 minute to obtain a wet-mixed soft material. The soft material is granulated with a swing granulator and dried to obtain extract granules;

[0037] Preparation of the volatile oil inclusion compound: Weigh β-cyclodextrin and place it in a ground round bottom flask, add an appropriate amount of water, heat and stir evenly to form a saturated solution; weigh the volatile oil and add an equal weight of absolute ethanol to mix well , Slowly added dropwise to the β-cyclodextrin saturated solution, stirred for 6 hours, cooled to room temperature, refrigerated for 12 hours, suction filtered, washed, vacuum dried, pulverized through an 80 mesh sieve to obtain the volatile oil inclusion compound;

[003...

Embodiment 3

21

[0042] Preparation of extract granules: pass dry extract powder and diluent dextrin through a 60-mesh sieve, mix, add ethanol as the first wetting agent, wet-mix and granulate for 3 minutes, then add purified water from the second wetting agent, and continue to wet Mix and granulate for 4 minutes to obtain a wet mixed soft material, granulate the soft material with a swing granulator, and dry it to obtain extract granules;

[0043] Preparation of the volatile oil inclusion compound: Weigh β-cyclodextrin and place it in a ground round-bottom flask, add an appropriate amount of water, heat and stir evenly to form a saturated solution; weigh the volatile oil and add an equal weight of absolute ethanol to mix well , Slowly added dropwise to the β-cyclodextrin saturated solution, stirred for 10 hours, cooled to room temperature, refrigerated for 18 hours, suction filtered, washed, vacuum dried, pulverized through an 80 mesh sieve to obtain the volatile oil inclusion compound;

[00...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine drug granule for treating cervical spondylosis and lumbar spondylosis and a preparation method thereof. The traditional Chinese medicine drug granule is prepared from extract particles and volatile oil clathrate compounds. The extract particles include dry extract powder, diluent and wetting agents. The volatile oil clathrate compounds include volatile oil and clathration materials. The weight ratio of the dry extract powder to the diluent in the extract particles is 1 to 0.3-1.0. The obtained traditional Chinese medicine drug granule is high in percent of pass, small in auxiliary material dosage, high in stability, suitable for transportation and storage in industrial production and capable of being conveniently taken by patients.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine granule for treating cervical spondylosis and lumbar spondylopathy and a preparation method thereof. Background technique [0002] Cervical spondylosis refers to a series of symptoms caused by cervical vertebral disc degeneration, cervical vertebral hypertrophy and hyperplasia, and neck injury, or cervical vertebral bone hyperplasia, or intervertebral disc prolapse, thickening of ligaments, stimulation or compression of the cervical spinal cord, cervical nerves, and blood vessels. Syndrome is a common clinical disease and frequently-occurring disease, which is more common in adults over 40 years old. Clinically, the main manifestations are headache, dizziness, neck and shoulder pain can radiate to the head and upper limbs, neck stiffness, limited mobility, heaviness of one shoulder and back, weakness of the upper limbs, nu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/66A61K9/16A61K47/48A61P19/08A61P29/00A61K35/64
Inventor 秦勇徐成康振华王琦游剑蔡雄徐晓军
Owner JIANGSU HONGHUI PHARM CO LTD
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