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Application of croton tiglium alkaloid in preparation of medicine for treating lung cancer

A technology of alkaloids and coptis alkaloids, applied in the field of medicine, can solve the problems of low effective rate, slow effect, poor curative effect, etc., and achieve the effect of convenient taking, quick effect, and mild medicinal properties

Inactive Publication Date: 2015-12-30
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides an application of croton alkaloids in the preparation of medicines for treating lung cancer, which solves the problems of slow effect, poor curative effect and low effective rate of medicines for treating lung cancer in the prior art

Method used

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  • Application of croton tiglium alkaloid in preparation of medicine for treating lung cancer
  • Application of croton tiglium alkaloid in preparation of medicine for treating lung cancer
  • Application of croton tiglium alkaloid in preparation of medicine for treating lung cancer

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preparation example Construction

[0023] A preparation method of a croton alkaloid drug for treating lung cancer of the present invention comprises the following steps: 1) taking polyethylene glycol 8000, heating to melt, stirring evenly to make a matrix; 2) taking croton alkaloid and naringin , baicalin alkaloids, purple quercetin, Liriodendron alkaloids, coptis alkaloids, dioscin and licorice alkaloids, ground and sieved to obtain mixed powder; 3) Add the mixed powder obtained in step 2) to step 2) In the obtained matrix, fully stir to make a uniform liquid medicine; 4) Drop the liquid medicine obtained in step 3) into simethicone oil at 2-4°C under the condition of heat preservation at 85-95°C, and take out after the dropping pills are formed , wipe off the simethicone oil on the surface of the dripping pills with absorbent paper, and let it dry naturally.

[0024] Preferably, in the step 4), the dropping speed is 30-60 drops / min, and the dropping distance is 2.0-4.0 cm.

[0025] Further, in the step 1), p...

Embodiment 1

[0027] A preparation method of croton alkaloid medicine for treating lung cancer, comprising the following steps: take 60 parts by weight of polyethylene glycol 8000, heat to melt, stir evenly, and make matrix; 5 parts by weight of croton alkaloid, 1 part by weight Naringin, 2 parts by weight of Scutellaria baicalensis alkaloids, 0.5 parts by weight of quercetin, 1 part by weight of Liriodendron alkaloids, 2 parts by weight of Coptis chinensis alkaloids, 1 part by weight of dioscin and 2 parts by weight of Glycyrrhizae alkaloids of one part were ground and sieved to obtain a mixed powder; the mixed powder was added to the above-mentioned matrix and stirred thoroughly to make a uniform medicinal solution; the above-mentioned medicinal solution was dripped into a two- In the methicone oil, take out the dripping pill after forming, wipe off the simethicone oil on the surface of the dropping pill with absorbent paper, and let it dry naturally.

[0028] Among them, croton alkaloids...

Embodiment 2

[0030] A preparation method of a croton alkaloid drug for treating lung cancer, comprising the following steps: take 70 parts by weight of polyethylene glycol 8000, heat it in a water bath at 85°C to melt, stir evenly, and make a matrix; 6 parts by weight of croton bio Alkali, 1.5 parts by weight of naringin, 3 parts by weight of baicalin alkaloids, 1 part by weight of quercetin, 1.5 parts by weight of Liriodendron alkaloids, 3 parts by weight of coptis alkaloids, 1.5 parts by weight of cracked fruit Grind and sieve dioscin and 3 parts by weight of licorice alkaloid to obtain a mixed powder; add the mixed powder to the above-mentioned matrix and fully stir to make a uniform medicinal liquid; drip the above-mentioned medicinal liquid under a heat preservation condition of 85°C Put it into simethicone oil at 3°C, wherein, the dropping speed is 30 drops / min, and the drop distance is 2.0cm. After the drop pills are formed, take them out, wipe off the simethicone oil on the surface ...

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Abstract

The invention discloses application of croton tiglium alkaloid in preparation of medicine for treating lung cancer, and belongs to the technical field of medicine. The medicine is prepared from, by weight, 5-10 parts of croton tiglium alkaloid, 1-2 parts of naringin, 2-4 parts of scutellaria baicalensis alkaloid, 0.5-2 parts of purple quercetin, 1-2 parts of liriodendron tulipifera alkaloid, 2-5 parts of coptidis rhizoma alkaloid, 1-3 parts of tacca plantaginea saponin and 2-6 parts of radix glycyrrhizae alkaloid. Croton tiglium alkaloid in the medicine restrains growth of lung adenocarcinoma cells A549 and promotes lung adenocarcinoma cells A549 to die through a Bax / Bcl-2 approach, medicine effects of all the raw materials of dropping pills supplement one another and bring out the best in one another, and the medicine has remarkable effects on restraining growth of lung cancer cells and promoting lung cancer cells to die under the mutual concurrent effects of all the raw materials, has an effect on treating lung cancer, is remarkable in curative effect, relieves pains of patients, prolongs lifetime, improves life quality, and provides a new direction for treatment of clinical lung cancer.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of a croton alkaloid in the preparation of a medicine for treating lung cancer. Background technique [0002] Lung cancer has already become one of the malignant tumors with the highest incidence in the world, 85% of which are non-small cell lung cancer (NSCLC). In my country, the incidence and mortality of lung cancer have risen rapidly in recent years. Currently, the means of treating lung cancer are still surgery, chemotherapy, radiotherapy, targeted therapy and biological immune support therapy. A large number of studies at home and abroad have shown that: lung cancer is a malignant tumor that easily metastasizes to multiple organs throughout the body. When it is discovered, it is mostly in the middle and late stage, and the timing of surgery is lost. Chemotherapy is often the first choice. [0003] In recent years, there has been no significant progress in...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/20A61P11/00A61P35/00A61K31/7048
Inventor 武晓张春玲孙荣丽
Owner QINGDAO CENT HOSPITAL
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