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Application of eucommia ulmoides lignan extract in preparation of PH (pulmonary hypertension) treatment drug

A technology of pulmonary arterial hypertension and Eucommia lignan, which is applied in the field of medicine, can solve the problems that there is no drug for pulmonary arterial hypertension.

Inactive Publication Date: 2016-01-20
欧阳冬生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no drug for the treatment of pulmonary arterial hypertension with Eucommia lignans or Eucommia lignans extracts as the main component in the market

Method used

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  • Application of eucommia ulmoides lignan extract in preparation of PH (pulmonary hypertension) treatment drug
  • Application of eucommia ulmoides lignan extract in preparation of PH (pulmonary hypertension) treatment drug
  • Application of eucommia ulmoides lignan extract in preparation of PH (pulmonary hypertension) treatment drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation of embodiment 1 eucommia lignan extract

[0045] Take 2Kg of bark of Eucommia ulmoides (with the outer skin removed), extract twice with 8L of 65% ethanol under reflux, each time for 1h, filter, combine the two extracts and concentrate to 800ml. Mix and load the sample with D101 macroporous resin (column volume of macroporous resin is 3 L), wash with water for 3 times of column volume, continue to wash with 1% ammonia water for 3 times of column volume, and then wash with water until neutral. Elute with 20% ethanol for 2 column volumes and 45% ethanol for 2.5 column volumes. The 45% ethanol eluate was concentrated to 600ml. The eluate was concentrated and dried to a powder. Using pinoresinol diglucoside as a control, the lignan content of Eucommia ulmoides lignan extract was 85% by ultraviolet detection, and the content of pinoresinol diglucoside by HPLC was 12.5%.

Embodiment 2

[0046] The preparation of embodiment 2 eucommia lignan extract

[0047] After the bark of Eucommia ulmoides was crushed, 9 L of 60% ethanol was added to reflux for extraction for 1 h, filtered, and the filter residue was extracted with 7 L of 60% ethanol for 1 h, filtered, the two extracts were combined, and concentrated until there was no alcohol smell to obtain a concentrated solution of about 3 L. The concentrated solution was passed through an AB-8 macroporous adsorption resin column, firstly eluted with 5L of water, then 7L of 60% ethanol, collected the 60% ethanol eluate, concentrated to 150ml, slowly added to 450ml of water, filtered, and concentrated to obtain Dry solid powder. Using pinoresinol diglucoside as a control, the lignan content of Eucommia ulmoides lignan extract was 51% detected by ultraviolet light, and the content of pinoresinol diglucoside detected by HPLC was 3.5%.

experiment example

[0049] Eucommia ulmoides is a traditional Chinese medicine with multiple functions, such as lowering blood pressure, improving immunity, and treating obesity. Eucommia lignan extract is its main active ingredient. Studies have shown that it can prevent blood vessel remodeling and Kidney damage has an inhibitory effect. By constructing monocrotaline-induced rat in vivo experimental model to study the inhibitory effect of Eucommia lignan extract on vascular remodeling and PDGF-induced in vitro cell experimental model to study its inhibitory effect on vascular smooth muscle proliferation, and based on this model To study the effect of Eucommia lignan extract on the accumulation of collagen and the expression of α-SMA, collagenI and collagenIII, the study showed that Eucommia lignan extract had an inhibitory effect on vascular remodeling in the process of pulmonary hypertension, which was discovered for the first time, according to which Carrying out the application research of eu...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of eucommia ulmoides lignan extract in preparation of a PH (pulmonary hypertension) treatment drug. Lignans in the eucommia ulmoides lignan extract account for 30%-90% of the total weight of the eucommia ulmoides lignan extract, and the content of an effective ingredient, namely pinoresinol diglucoside, in the lignans accounts for 1%-15% of the total weight of the eucommia ulmoides lignan extract.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of eucommia lignan extracts in the preparation of medicines for treating pulmonary hypertension. Background technique [0002] Pulmonary hypertension is a disease characterized by pulmonary arteriolar vascular remodeling and pulmonary artery smooth muscle proliferation, which causes chronic precapillary pulmonary hypertension, increases pulmonary artery vascular tone, and leads to right heart failure, a disease that seriously threatens human life and health. Different from hypertension, pulmonary hypertension has the characteristics of low survival rate, poor prognosis and difficult clinical treatment. The 5-year survival rate of patients is comparable to that of breast cancer. Common drugs that lower blood pressure, such as ACEI and ARB, cannot be used for the treatment of pulmonary hypertension. The current treatment for pulmonary hypertension mainly uses dru...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61P11/00A61P9/12
Inventor 欧阳冬生李晓晖李先伟严谨胡凯李振宇郭成贤王俊杰
Owner 欧阳冬生
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