Traditional Chinese medicine composition used for preventing and/or treating liver diseases and preparation method thereof
A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for preventing and/or treating liver disease and its preparation field, can solve the problem that acid tannin components and specific harmful impurities cannot be removed, chronic gastritis needs to be taken in reduced dose, and women After the suspension of taking the drug and the large amount of extracts, the effect of reducing the incidence of gastrointestinal adverse reactions, optimizing the quality and efficacy of the drug, and reducing the clinical dosage
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Embodiment 1
[0038] In this example, the traditional Chinese medicine composition of the present invention is prepared into capsules, and the specific formula and preparation method are as follows.
[0039] (1) Formula
[0040] 250 grams of capillary root, 125 grams of Radix Radix, 125 grams of angelica, 125 grams of white peony root, 250 grams of salvia miltiorrhiza, 125 grams of turmeric, 250 grams of astragalus, 125 grams of codonopsis, 125 grams of Alisma, 125 grams of sealwort, 125 grams of rehmannia, 125 grams of yam gram, hawthorn 100 grams, Liushenqu 100 grams, Gentiana 100 grams, licorice 100 grams.
[0041] (2) Preparation method
[0042]Mix the medicinal materials of each flavor according to the parts by weight, add water to decoct 3 times, add 10 times of water, 8 times of water, and 8 times of water each time, decoct for 2 hours, 1.5 hours, 1.5 hours each time, collect and decoct The liquid is filtered through a ceramic membrane, the ceramic membrane has a pore size of 5 μm,...
Embodiment 2
[0043] Embodiment 2: Screening test of ceramic membrane separation parameters of the present invention
[0044] 1. Pressure selection for ceramic membrane separation
[0045] The various medicinal materials were fed according to the weight parts of the present invention, and the collected decoctions were tested according to the following parameters (wherein the ceramic membrane pore size was 5 μm, and the temperature was controlled at ≤ 40° C.), see Table 1.
[0046] Table 1: Ceramic Membrane Separation Pressure Screening
[0047]
[0048]
[0049] As can be seen from Table 1, the 2nd group and the 3rd group are similar in effect, but because the easily damaged experimental equipment when the pressure is too large (6-8bar), therefore determine that 3-5bar is optimal choice in the preparation method of the present invention.
[0050] 2. Temperature selection of ceramic membrane separation
[0051] The various medicinal materials were fed according to the parts by weig...
Embodiment 3
[0056] Embodiment 3: Nanofiltration membrane parameter screening test
[0057] The ingredients of traditional Chinese medicine are complex and have different properties. Using traditional separation and purification processes such as water extraction and alcohol precipitation, alcohol extraction and water precipitation, the active ingredients will be lost in large quantities with precipitation, which will affect the effectiveness of the product. However, the concentration and separation and purification carried out by the nanofiltration membrane in the present invention can effectively avoid the problems caused thereby, effectively and directionally separate specific impurities (mainly salicylic acid) and small molecular sugar components, and the production time is short and no Steam realizes energy saving and environmental protection.
[0058] Carry out ceramic membrane filtration and nanofiltration membrane concentration of the present invention after the ceramic membrane ...
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