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Traditional Chinese medicine composition used for preventing and/or treating liver diseases and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for preventing and/or treating liver disease and its preparation field, can solve the problem that acid tannin components and specific harmful impurities cannot be removed, chronic gastritis needs to be taken in reduced dose, and women After the suspension of taking the drug and the large amount of extracts, the effect of reducing the incidence of gastrointestinal adverse reactions, optimizing the quality and efficacy of the drug, and reducing the clinical dosage

Active Publication Date: 2016-01-20
SHIJIAZHUANG DONGFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For traditional Chinese medicine preparations, the traditional production process is mainly water extraction to enrich the active ingredients. On the one hand, it leads to a lot of extracts and cannot remove a large number of acidic tannin components and specific harmful impurities that affect the absorption and digestion functions (such as Radix Radix and other medicinal materials). Salicylic acid-based), taking a large dose at the same time (Qianggan Capsules take 10 capsules per day
) and cause severe gastrointestinal adverse reactions (Qianggan Capsules should be taken in reduced doses for patients with gastric, duodenal ulcers or high-acid chronic gastritis, and women should suspend taking them); The use of liver capsules in patients with diabetic fatty liver is very poor. This is because the adverse reactions of Qianggan capsules in the gastrointestinal tract can disturb the digestive function of diabetic patients and cause blood sugar disorders; Extract and enrich the free sugar components together, which will affect the blood sugar level of diabetic fatty liver patients after taking it, while the traditional water extraction and alcohol precipitation to remove sugar components will also cause the loss of active ingredients

Method used

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  • Traditional Chinese medicine composition used for preventing and/or treating liver diseases and preparation method thereof
  • Traditional Chinese medicine composition used for preventing and/or treating liver diseases and preparation method thereof
  • Traditional Chinese medicine composition used for preventing and/or treating liver diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] In this example, the traditional Chinese medicine composition of the present invention is prepared into capsules, and the specific formula and preparation method are as follows.

[0039] (1) Formula

[0040] 250 grams of capillary root, 125 grams of Radix Radix, 125 grams of angelica, 125 grams of white peony root, 250 grams of salvia miltiorrhiza, 125 grams of turmeric, 250 grams of astragalus, 125 grams of codonopsis, 125 grams of Alisma, 125 grams of sealwort, 125 grams of rehmannia, 125 grams of yam gram, hawthorn 100 grams, Liushenqu 100 grams, Gentiana 100 grams, licorice 100 grams.

[0041] (2) Preparation method

[0042]Mix the medicinal materials of each flavor according to the parts by weight, add water to decoct 3 times, add 10 times of water, 8 times of water, and 8 times of water each time, decoct for 2 hours, 1.5 hours, 1.5 hours each time, collect and decoct The liquid is filtered through a ceramic membrane, the ceramic membrane has a pore size of 5 μm,...

Embodiment 2

[0043] Embodiment 2: Screening test of ceramic membrane separation parameters of the present invention

[0044] 1. Pressure selection for ceramic membrane separation

[0045] The various medicinal materials were fed according to the weight parts of the present invention, and the collected decoctions were tested according to the following parameters (wherein the ceramic membrane pore size was 5 μm, and the temperature was controlled at ≤ 40° C.), see Table 1.

[0046] Table 1: Ceramic Membrane Separation Pressure Screening

[0047]

[0048]

[0049] As can be seen from Table 1, the 2nd group and the 3rd group are similar in effect, but because the easily damaged experimental equipment when the pressure is too large (6-8bar), therefore determine that 3-5bar is optimal choice in the preparation method of the present invention.

[0050] 2. Temperature selection of ceramic membrane separation

[0051] The various medicinal materials were fed according to the parts by weig...

Embodiment 3

[0056] Embodiment 3: Nanofiltration membrane parameter screening test

[0057] The ingredients of traditional Chinese medicine are complex and have different properties. Using traditional separation and purification processes such as water extraction and alcohol precipitation, alcohol extraction and water precipitation, the active ingredients will be lost in large quantities with precipitation, which will affect the effectiveness of the product. However, the concentration and separation and purification carried out by the nanofiltration membrane in the present invention can effectively avoid the problems caused thereby, effectively and directionally separate specific impurities (mainly salicylic acid) and small molecular sugar components, and the production time is short and no Steam realizes energy saving and environmental protection.

[0058] Carry out ceramic membrane filtration and nanofiltration membrane concentration of the present invention after the ceramic membrane ...

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Abstract

The invention provides a traditional Chinese medicine composition used for preventing and / or treating liver diseases. The traditional Chinese medicine composition is characterized by being prepared from, by weight, 250 parts of capillary artemisia, 125 parts of isatis roots, 125 parts of angelica sinensis, 125 parts of white paeony roots, 250 parts of salvia miltiorrhiza, 125 parts of curcuma aromatica, 250 parts of astragalus membranaceus, 125 parts of codonopsis pilosula, 125 parts of rhizoma alismatis, 125 parts of sealwort, 125 parts of rehmannia, 125 parts of Chinese yams, 100 parts of hawthorn fruits, 100 parts of medicated leaven, 100 parts of large-leaved gentian and 100 parts of licorice roots. According to a preparation method, hazardous substances in the composition are filtered out, daily dosage is reduced, the safety and medication compliance of the product are greatly improved, the effectiveness of the product is guaranteed, and the clinic use patient range of the product is widened.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for preventing and / or treating liver diseases and a preparation method thereof. Background technique [0002] Fatty liver disease is a serious threat to the health of Chinese people, becoming the second largest liver disease after viral hepatitis, and has been recognized as a common cause of hidden cirrhosis. In some occupational groups (white-collar workers, taxi drivers, professional managers, individual owners, government officials, senior intellectuals, etc.) the average incidence of fatty liver is 25%; The incidence rate is 50%; the incidence rate of fatty liver in alcoholics and alcoholics is 58%; the incidence rate of fatty liver in sub-healthy people who often suffer from insomnia, fatigue, lack of food, and gastrointestinal dysfunction is about 60%. In recent years, the age of the fatty liver population h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/16
Inventor 马旭伟赵环李召红张晶川
Owner SHIJIAZHUANG DONGFANG PHARMA