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Application of NONRATT021972 small interference RNA in preparation of drugs used for treating nervous tissue NONRATT021972 dysfunction and related diseases

A NONRATT021972, nerve tissue technology, applied in nervous system diseases, drug combinations, pharmaceutical formulations, etc., can solve the problem of not much research on long non-coding RNAs

Active Publication Date: 2016-01-20
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, breakthroughs have been made in the research of non-coding RNAs (such as microRNA, siRNA and piRNA) with a length of less than 50 nucleotides, but there are not many studies on functional long non-coding RNAs

Method used

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  • Application of NONRATT021972 small interference RNA in preparation of drugs used for treating nervous tissue NONRATT021972 dysfunction and related diseases
  • Application of NONRATT021972 small interference RNA in preparation of drugs used for treating nervous tissue NONRATT021972 dysfunction and related diseases
  • Application of NONRATT021972 small interference RNA in preparation of drugs used for treating nervous tissue NONRATT021972 dysfunction and related diseases

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Experimental program
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Embodiment 1

[0016] Using methods well known in the art, prepare NONRATT021972 NONRATT021972, which is suitable for the preparation of NONRATT021972 long non-coding ribonucleic acid for the diagnosis, prevention and treatment of concurrent diseases. Encoding ribonucleic acid NONRATT021972 small interfering RNA preparation.

[0017] 1. Materials and methods.

[0018] 1. Animals and grouping.

[0019] Healthy Sprague-Dawley (SD) rats were provided by the Department of Experimental Animal Science, School of Medicine, Nanchang University. 60 healthy SD male rats, weighing about 200g, were randomly divided into 2 groups after adaptive feeding for 1 week, with 8 rats in the control group (Ctrl) fed with basic feed; the remaining rats (52 rats) were the diabetes model group, Feed with high-sugar and high-fat feed (high-sugar and high-fat feed formula: 66.5% of basic feed, 20% of sucrose, 10% of lard, 2.5% of cholesterol, 1% of sodium cholate, made into balls and placed in a constant temperature...

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Abstract

The invention provides a long non-coding ribonucleic acid NONRATT021972 small interference RNA in preparation of drugs used for treating nervous tissue NONRATT021972 dysfunction and related diseases. According to experiment results, it is observed that the long non-coding NONRATT021972 small interference RNA can inhibit behavior reaction of rats with type w diabetes to pain sensation, change nerve conduction velocity, reduce the content of cell inflammatory factor-tumor necrosis factor (TNF-alpha) in the serum of the rats with diabetes and improve the activity of catalase (CAT) and superoxide dismutase (SOD) in serum of the rats with diabetes. It is proved that the long non-coding NONRATT021972 small interference RNA acts on nervous tissue NONRATT021972 dysfunction and related diseases and is applicable to the drugs, reagents and preparations used for diagnosis, prevention and treatment of nervous tissue NONRATT021972 dysfunction and related diseases.

Description

technical field [0001] The invention relates to the application in the preparation of medicines for treating abnormal function of long non-coding ribonucleic acid NONRATT021972 in nerve tissue and related diseases. Background technique [0002] With the completion of the genome sequencing project and the application of next-generation deep sequencing technology, it has been found that more than 95% of the transcribed sequences in mammalian cells are noncoding RNA (ncRNA). Non-coding RNAs are a class of RNA molecules that do not encode proteins but have biological regulatory functions. The basic life activities of organisms are also related to the pathophysiological processes of some important diseases. Non-coding RNA includes short non-coding ribonucleic acid (including siRNA, miRNA, piRNA) and long non-coding ribonucleic acid (longnon-coding RNA, lncRNA). Long non-coding RNA (lncRNA) is longer than 200 bases (200nt). At present, breakthroughs have been made in the resear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K31/713A61P25/00
Inventor 梁尚栋彭海英涂桂花李桂林刘双梅徐宏高云徐昌水林加日虞诗诚樊波
Owner NANCHANG UNIV
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