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Therapy-progress-level monitoring device and method

A monitoring device and progress technology, which is applied in the direction of treatment, phototherapy, radiation therapy, etc., can solve the problem of not being able to monitor sufficient distribution of photosensitive substances

Inactive Publication Date: 2016-01-20
ARAI MEDPHOTON RES LAB
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Problems solved by technology

[0013] However, in the device of Patent Document 2, although it is possible to monitor the progress of photodynamic therapy for cancerous tissue or the like by utilizing the accumulation of photosensitive substances in tissue lesions, it cannot monitor the extracellular matrix in the tissue to be treated. and the progress of photodynamic therapy for infectious diseases or arrhythmia with sufficient distribution of photosensitive substances in blood vessels and continuous supply of sufficient amounts

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  • Therapy-progress-level monitoring device and method
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  • Therapy-progress-level monitoring device and method

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Embodiment

[0222] Hereinafter, the present invention will be described more specifically through examples.

[0223] In this example, the relationship between the PBI calculated by the above formula 1 and formula 2 and the actual measured gangrene depth d nec The relationship between the research is calculated by the above formula 1 and formula 2 to estimate the treatment depth nec Presumptive actual measured gangrene depth d nec possibility.

[0224] In this example, dogs (body weight: 12.4 ± 0.8 kg, N = 16) were subjected to an intercostal thoracotomy to expose the heart, and 2.5 and 5.0 mg / kg of the PDT drug taraporfin sodium were administered intravenously.

[0225] The average drug concentration in the plasma under the situation of 2.5mg / kg administration was 15.85 μg / ml (S.D.: 2.00), and the average drug concentration in the plasma under the situation of 5.0mg / kg administration was 36.16 μg / ml (S.D. : 7.99).

[0226] Fifteen minutes after administration, the ventricular muscle w...

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Abstract

Provided are a therapy-progress-level monitoring device and method which make it possible to know in real time during therapy the therapy depth of extracellular photodynamic therapy. The device is a photodynamic therapy progress-level monitoring device (1), and is provided with: an irradiation means (30) for irradiating, with excitation light of a wavelength capable of exciting a photosensitive substance, a photosensitive substance sustainably supplied by vascular permeability and distributed in the extracellular fluid of an organism and the transcellular fluid thereof; detection means (30, 20, 13) for detecting, during a detection period, the fluorescence intensity produced when the photosensitive substance excited by a reaction between the excitation light and the photosensitive substance is inactivated into a ground state; a depth calculation means (14) for calculating, in real time, an indicator value estimating the volume or depth of the therapy region by using the fluorescence intensity during the detection period; and output means (14, 16, 17) for outputting the indicator value in real time to a display unit or a storage unit.

Description

technical field [0001] The present invention relates to a treatment progress monitoring device and method for monitoring the progress of photodynamic therapy. Background technique [0002] Tachyarrhythmia (tachyarrhythmia) is a cardiac arrhythmia that occurs through transmission to abnormally excited normal myocardial tissue, or through an excited rotating circuit (reentry circuit) that forms an electric current in myocardial tissue. Usually, the excitation of the heart is controlled at a normal rate by excitation from the sinus node (sinus rhythm), in the case of tachyarrhythmia, by abnormal excitation from a part of the heart tissue, the heart beats at a rate faster than sinus rhythm The ratio continues. The reentry loop refers to a portion where the normal current excitation transmission is not performed due to the presence of a transmission disorder in the myocardial tissue, but the excitation reciprocates in a loop. [0003] Currently, in the treatment of tachyarrhyth...

Claims

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Application Information

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IPC IPC(8): A61N5/067A61N5/06
CPCA61N5/062A61N2005/0628A61N2005/0626A61N5/0603A61B2017/00066A61B2018/00351A61B5/0071A61B5/6852A61B5/6869A61B5/0084A61B5/1076A61B5/4848A61B5/1459
Inventor 荒井恒宪高桥芽意伊藤亚莉沙
Owner ARAI MEDPHOTON RES LAB
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