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A kind of sulfachlorpyrazine soluble powder and preparation method thereof

A sulfachloropyrazine sodium and soluble technology is applied to the sulfachloropyrazine sodium soluble powder and the field of preparation thereof, which can solve the problem of reducing poultry feed intake and feed utilization rate, restricting the survival and development of animal husbandry, aquaculture and animal husbandry. Loss and other problems, to achieve the effect of extensive drug use, improved bioavailability, and increased drug stability

Active Publication Date: 2018-06-22
河南后羿制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Massive proliferation of coccidia in the small intestine can lead to tissue damage, reducing feed intake and feed utilization in poultry
[0004] Poultry in large-scale farms are susceptible to coccidiosis, which not only endangers the health of poultry, but also restricts the survival and development of animal husbandry, especially young animals. Once infected with such diseases, it is easy to cause death. If the performance is reduced, the economic benefits they produce will inevitably decline, causing immeasurable losses to my country's aquaculture and animal husbandry.

Method used

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  • A kind of sulfachlorpyrazine soluble powder and preparation method thereof

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Effect test

Embodiment 1

[0021] A soluble powder of sulfachlorpyrazine sodium, comprising the following raw materials in parts by weight: 10-30 parts of sulfachlorpyrazine sodium, 2-5 parts of sodium carbonate, 0.1-0.5 parts of disodium edetate, 70-85 parts of sucrose share.

[0022] Disodium edetate is a complexing agent and a stabilizer, sucrose is an auxiliary material, and sodium carbonate adjusts the pH of the solution to increase the solubility of sulfachlorpyrazine sodium in water.

[0023] The preparation method of the sulfachlorpyrazine sodium soluble powder, the preparation steps are:

[0024] (1), weigh each component raw material by weight;

[0025] (2) Mix sulfachlorpyrazine sodium and sodium carbonate, then add disodium edetate, mix well, pulverize or finely grind;

[0026] (3) Add sucrose to the medicinal powder prepared in step (2), mix evenly, and pass through a 40-80 mesh sieve to obtain sulfachlorpyrazine sodium soluble powder.

Embodiment 2

[0028] A sulfachlorpyrazine sodium soluble powder comprises the following raw materials in parts by weight: 15 parts of sulfachlorpyrazine sodium, 2 parts of sodium carbonate, 0.1 part of disodium edetate, and 82.9 parts of sucrose.

[0029] Disodium edetate is a complexing agent and a stabilizer, sucrose is an auxiliary material, and sodium carbonate adjusts the pH of the solution to increase the solubility of sulfachlorpyrazine sodium in water.

[0030] The preparation method of the sulfachlorpyrazine sodium soluble powder: (1), weighing the raw materials of each component by parts by weight;

[0031] (2) Mix sulfachlorpyrazine sodium and sodium carbonate, then add disodium edetate, mix well, pulverize or finely grind;

[0032] (3) Add sucrose to the medicinal powder prepared in step (2), and pass through a 60-mesh sieve to obtain sulfachlorpyrazine sodium soluble powder.

Embodiment 3

[0034] A sulfachlorpyrazine sodium soluble powder comprises the following raw materials in parts by weight: 15 parts of sulfachlorpyrazine sodium, 5 parts of sodium carbonate, 0.5 parts of disodium edetate, and 79.5 parts of sucrose.

[0035] Disodium edetate is a complexing agent and a stabilizer, sucrose is an auxiliary material, and sodium carbonate adjusts the pH of the solution to increase the solubility of sulfachlorpyrazine sodium in water.

[0036] The preparation method of the sulfachlorpyrazine sodium soluble powder: (1), weighing the raw materials of each component by parts by weight;

[0037] (2) Mix sulfachlorpyrazine sodium and sodium carbonate, then add disodium edetate, mix well, pulverize or finely grind;

[0038] (3) Add sucrose to the medicinal powder prepared in step (2), and pass through a 40-mesh sieve to obtain sulfachlorpyrazine sodium soluble powder.

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Abstract

The invention provides a dissolvable sulfachloropyrazine sodium powder, and belongs to the technical field of veterinary anti-parasitic medicinal preparation. The dissolvable sulfachloropyrazine sodium powder mainly comprises the following components in part by weight: 10-30 parts of sulfachloropyrazine sodium, 2-5 parts of sodium carbonate, 0.1-0.5 part of disodium ethylenediamine tetraacetic acid and 70-85 parts of saccharose. Compared with a melting technology or an inclusion technology, a preparation method of the dissolvable sulfaclozine powder is simple, convenient and quick; types of added auxiliary materials are small; and the preparation method is easy to operate and low in cost and the prepared dissolvable sulfachloropyrazine sodium powder is easy to store, can be industrially produced in a large scale, and is suitable for industrial large-scale production. The dissolvable sulfachloropyrazine sodium powder is high in operability, good in stability, convenient to take and good in palatability. The dissolvable sulfachloropyrazine sodium powder can be administrated at any time, and pharmacy modes are extensive, for example, the dissolvable sulfachloropyrazine sodium powder can serve as a mixed-drinking agent, a mixed-feeding agent, an additive and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a sulfachlorpyrazine sodium soluble powder and a preparation method thereof. Background technique [0002] Sulfachlorpyrazine sodium has anti-parasitic effect, belongs to sulfonamide anticoccidial drugs, and is mostly used for short-term application when coccidia outbreaks occur. The basic structure of sulfachlorpyrazine sodium is similar to that of p-aminobenzoic acid, which can compete with each other for dihydrofolate synthase, resulting in a decrease in the synthesis of dihydrofolate in parasites, and ultimately affects the synthesis of nucleoproteins, thereby inhibiting the growth and reproduction of parasites. [0003] Coccidia mainly parasitize in intestinal cells, causing coccidiosis. Coccidia have strict selectivity to the host, and different species of livestock and poultry have different types of coccidia, and there is no cross-infectio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/635A61K47/18A61P33/02
Inventor 许贤会刘应鹏
Owner 河南后羿制药有限公司