H2O2-responsive fluorescent single-molecule conjugated polymers and micelles, preparation methods and applications

A molecular conjugation, H2O2 technology, applied in the field of biomedicine, can solve the problems of photobleaching concentration-dependent data distortion, affecting probe sensitivity, etc., and achieve the effect of excellent photostability
CN105367805BActive Publication Date: 2018-05-04SHANGHAI JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI JIAOTONG UNIV
Publication Date
2018-05-04

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Abstract

The invention relates to the technical field of biomedicine, in particular to a hydrogen peroxide (H2O2)-responsive fluorescent single-molecule conjugated polymer micelle that can be used to identify tumor cells and normal cells, as well as its preparation method and application. The fluorescent unimolecular conjugated polymer in the present invention comprises a hydrophobic hyperbranched conjugated polymer core and a hydrophilic polymer arm, and the hydrophobic hyperbranched conjugated polymer core and a hydrophilic polymer arm They are linked by boronate bonds that respond to H2O2. The micelle solution formed by the assembly of the fluorescent single-molecule conjugated polymer of the present invention can specifically only respond to H2O2 in tumor cells and undergo color changes. Intracellular H2O2 has fluorescent imaging with different colors, which can achieve the purpose of distinguishing tumor cells from normal cells.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a H 2 o 2 Responsive fluorescent single-molecule conjugated polymer and micelles, preparation method and application, the fluorescent single-molecule conjugated polymer micelles can be used to distinguish tumor cells and normal cells. Background technique

[0002] In recent years, cancer-related molecular imaging has played an increasingly important role in the diagnosis and treatment of cancer. h 2 o 2 As a cell-transduced second messenger, it is involved in the regulation of various physiological processes. Any H caused by environmental stress or genetic mutation 2 o 2 The abnormal production and accumulation of the human body will lead to some diseases, including cancer, aging, cardiovascular disease, Alzheimer's disease, Parkinson's disease and other diseases. If intracellular H 2 o 2 Detection and imaging will be of great significance to disease diagnosis, preve...

Claims

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