Butyl phthalide medicinal composite, preparation method and sustained-release preparation thereof

A technology for drug complexes and sustained-release preparations, applied in drug combinations, drug formulations, drug delivery, etc., can solve the problems of cumbersome and complex preparation processes, poor drug stability, and complex components, and achieve good economy and high drug stability , The effect of simple preparation method

Active Publication Date: 2016-03-09
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a butylphthalide drug complex and its preparation method and sustained-release preparation, to solve the existing butylphthalide solid dosage form with complex components, small drug loading, poor drug stability and cumbersome preparation process complex, time-consuming questions

Method used

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  • Butyl phthalide medicinal composite, preparation method and sustained-release preparation thereof
  • Butyl phthalide medicinal composite, preparation method and sustained-release preparation thereof
  • Butyl phthalide medicinal composite, preparation method and sustained-release preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Weigh 500 g of ordinary medicinal silicon dioxide and 100 g of racemic butylphthalide, and spray the butylphthalide into the silicon dioxide under stirring and mix evenly to obtain a solid powdery butylphthalide drug complex. The prepared powder can be prepared into various dosage forms such as granules, capsules or tablets by adding suitable auxiliary materials.

Embodiment 2

[0031] Weigh silica M-5P500g and racemic butylphthalide 500g, put the silicon dioxide in the fluidized bed, start the machine to make the silicon dioxide in a fluidized boiling state, spray butylphthalide into it, and get solid powdery butylphthalide drug compound The SEM image of the prepared butylphthalide drug complex is as follows figure 1 shown. The prepared powder can be prepared into various dosage forms such as granules, capsules or tablets by adding suitable auxiliary materials.

Embodiment 3

[0033] Weigh silica 244FP500g and racemic butylphthalide 1000g, put the silicon dioxide in the granulator, stir continuously and at the same time spray the butylphthalide into the silicon dioxide and mix evenly to get the solid powdery butylphthalide drug complex. The SEM figure of the prepared butylphthalide drug complex is as follows figure 2 shown. The prepared powder can be prepared into various dosage forms such as granules, capsules or tablets by adding suitable auxiliary materials.

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Abstract

The invention discloses a butyl phthalide medicinal composite, which comprises butyl phthalide and silicon dioxide according to a mass ratio of 0.1-4:1. The preparation method comprises the following steps: weighing butyl phthalide and silicon dioxide, spraying butyl phthalide into silicon dioxide powder, and evenly mixing to obtain the powdery butyl phthalide medicinal composite. At the same time, the invention also discloses a sustained-release preparation of the butyl phthalide medicinal composite. The sustained-release preparation is characterized in that the butyl phthalide medicinal composite is taken as the active component, which is wrapped by one or more pharmaceutically-acceptable sustained-release coating materials. The preparation method is simple, the preparation time is short, the cost is low, and the preparation method is economic. The prepared medicinal composite has the advantages that the drug volatilization is effectively controlled, the stability is high, the drug loading capacity is large, the volume is small, and the dosage form is convenient for oral taking. The shortages of conventional commercial oral butyl phthalide preparations in clinic are overcome.

Description

technical field [0001] The invention relates to a butylphthalide drug preparation and a preparation method thereof, in particular to a butylphthalide drug complex, a preparation method thereof and a slow-release preparation. Background technique [0002] Butylphthalide (3-n-butylphthalide, NBP for short), full name 3-butyl-1(H)-isobenzofuranone, also known as apigenin A, is a racemate extracted from celery seed , can also be artificially synthesized. Butylphthalide is a light yellow clear oily liquid with celery aroma and strong volatility. It is easily soluble in methanol, soluble in ethanol, ether and chloroform, but insoluble in water. Its molecule contains a chiral carbon atom, so it has two optical isomers, namely L-butylphthalide and D-butylphthalide. Pharmacodynamic studies have shown that butylphthalide can reduce the infarction after focal cerebral ischemia, increase cerebral blood flow in the ischemic area and improve microcirculation in the ischemic area. Reduc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/00A61K31/365A61K47/04A61K47/34A61P9/10
CPCA61K9/0002A61K9/143A61K9/1641A61K9/2853A61K31/365
Inventor 胡连栋
Owner HEBEI UNIVERSITY
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