Measuring apparatus for concentrations of nitric oxide and carbon monoxide in expired air

A carbon monoxide and nitric oxide technology, applied in the field of human exhaled gas analysis, can solve the problems of difficulty in real-time measurement of eNO or eCO concentration, slow response time, etc.

Active Publication Date: 2016-03-09
SUNVOU MEDICAL ELECTRONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 3) The response time of other existing detection methods (such as electrochemical sensors) is slow, and the response time to reach 9

Method used

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  • Measuring apparatus for concentrations of nitric oxide and carbon monoxide in expired air
  • Measuring apparatus for concentrations of nitric oxide and carbon monoxide in expired air
  • Measuring apparatus for concentrations of nitric oxide and carbon monoxide in expired air

Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0027] The device of the present invention is composed of a sampling module (100) and an analysis module (200). The sampling module is composed of a flow regulator (101), a shut-off valve (405), and a sampling pump (601) connected in series, wherein the flow regulator (101) Connected to flow / pressure sensor (201) and CO 2 The sensor (202), between the flow regulator (201) and the sampling pump (601), is connected in parallel with the air chamber one (301), the solenoid valve one (401), the solenoid valve six (406) and the air chamber connected to the air chamber one. Chamber two (302), solenoid valve two (402) and solenoid valve seven (407) connected front and back to gas chamber one; the analysis module consists of gas chamber one (301), solenoid valve one (401) or gas chamber two (302), solenoid valve two (402), three-way valve one (403), analysis pump (602), three-way valve two (404), gas humidity regulator (701), NO sensor (801), solenoid valve six (406) or solenoid valve...

specific Embodiment approach 2

[0039] Another device for measuring breath nitric oxide and carbon monoxide concentrations is composed of a sampling module (100) and an analysis module (200). The sampling module consists of a flow regulator (101), a shut-off valve (401), an air chamber ( 301), the sampling pump (601) is connected in series, and the flow / pressure sensor (201) and CO are connected to the flow regulator (101). 2 The sensor (202), the cut-off valve (401) is located on the air branch between the flow regulator and the gas chamber (301); the analysis module is sequentially composed of the gas chamber (301), the gas humidity regulator (701), the NO sensor (801), CO sensor (802), analysis pump (602), CO filter (502), and NO filter (501) constitute a circulating gas circuit.

[0040] When the subject begins to exhale, open the flow regulator (101) and the cut-off valve (405), and perform feedback adjustment according to the preset flow rate. At this time, the exhalation is directly discharged into th...

specific Embodiment approach 3

[0041] Another device for measuring breath nitric oxide and carbon monoxide concentrations is composed of a sampling module (100) and an analysis module (200). The sampling module consists of a flow regulator (101), a shut-off valve (405), a sampling pump ( 601) in series, where the flow regulator (101) is connected with a flow / pressure sensor (201) and CO 2 The sensor (202), the cut-off valve (405) is located on the branch air path between the flow regulator and the air chamber, and the air chamber one (301) and the Solenoid valve 1 (401), solenoid valve 6 (406) and gas chamber 2 (302) connected back and forth to gas chamber 1, solenoid valve 2 (402) and solenoid valve 7 (407) connected to gas chamber 1 back and forth; the analysis The module consists of gas chamber one (301), solenoid valve one (401) or gas chamber two (302), solenoid valve two (402), three-way valve one (403), analysis pump (602), three-way valve two ( 404), gas humidity regulator (701), NO sensor (801), s...

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Abstract

The invention provides a measuring apparatus for the concentrations of nitric oxide and carbon monoxide in expired air. The measuring apparatus is composed of a sampling module and an analysis module. The sampling module is formed by tandem connection of a flow regulator, a stop valve and a sampling pump, wherein the flow regulator is connected with a flow/pressure sensor and a CO2 sensor, and a group consisting of an air chamber I, a solenoid valve I and a solenoid valve VI and a group consisting of an air chamber II, a solenoid valve II and a solenoid valve VII are arranged between the flow/pressure regulator and the sampling pump in a parallel connection manner, the solenoid valve I and the solenoid valve VI are connected with the air chamber I and respectively located before and behind the air chamber I, and the solenoid valve II and the solenoid valve VII are connected with the air chamber II and respectively located before and behind the air chamber II. A circulation air path is formed in the analysis module by the air chamber I, the solenoid valve I or the air chamber II, the solenoid valve II, a tee valve I, an analysis pump, a tee valve II, an air humidity regulator, a NO sensor, the solenoid valve VI or the solenoid valve VII; a normally open end of the tee valve I is connected with the front of the air chamber I or the air chamber II and with the analysis pump, and a passage switching end of the tee valve I is connected with the front of the air chamber I or the air chamber II and with a NO filter and the analysis pump; and a normally open end of the tee valve II is connected with the analysis pump, the air humidity regulator and the NO sensor, and a passage switching end of the tee valve II is connected with the analysis pump, a CO sensor and a CO filter.

Description

technical field [0001] The invention relates to the field of human exhaled gas analysis. Background technique [0002] The measurement of the composition and concentration of the human body's exhaled gas can assist doctors in diagnosing patients' diseases, monitoring disease states, and observing treatment effects. [0003] Exhaled nitric oxide (eNO) is used for the diagnosis and monitoring of respiratory system inflammation, and exhaled carbon monoxide (eCO) is used for the diagnosis and monitoring of respiratory and circulatory system diseases. This is because the endogenous gas signal molecules NO and CO respectively Produced by the oxidative deamination of arginine in cortical cells and the decomposition of heme, infection, allergy, trauma and other inflammatory factors can cause NO by increasing the expression of inducible NO synthase (iNOS) and heme oxygenase (HO1). Significantly increased with CO concentration and can be quantified by exhaled breath analysis. Pulmon...

Claims

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Application Information

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IPC IPC(8): G01N33/48G01N1/24
Inventor 曹青韩杰
Owner SUNVOU MEDICAL ELECTRONICS
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