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Method for preparing titanium dioxide nanotube with antibacterial and anti-cancer properties

A technology of titanium dioxide and nanotubes, which is applied in the field of preparation of titanium dioxide nanotubes with antibacterial and anticancer properties, can solve the problems of patient danger, environmental pollution, solvent residue, etc., and achieve simple treatment methods, long-lasting antibacterial and anticancer effects, good biological active effect

Active Publication Date: 2016-03-16
嘉兴慧泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, some iridium complexes have poor water solubility. If they are directly introduced into the surface of titanium dioxide nanotubes, more organic solvents need to be used, which will pollute the environment, and there may be solvent residues on the titanium dioxide nanotubes, which will cause danger to patients.

Method used

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  • Method for preparing titanium dioxide nanotube with antibacterial and anti-cancer properties
  • Method for preparing titanium dioxide nanotube with antibacterial and anti-cancer properties
  • Method for preparing titanium dioxide nanotube with antibacterial and anti-cancer properties

Examples

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Effect test

Embodiment 1

[0025] The method for preparing titanium dioxide nanotubes with antibacterial and anticancer properties in this scheme includes the following steps:

[0026] 1) Dissolve 4 parts by weight of m-carboxybenzaldehyde in 12 parts by weight of toluene, add 10 parts by weight of 1-(9-anthryl)ethanol, and then add 1 part by weight of sulfuric acid with a concentration of 98%, and heat to 110°C with stirring and reflux 2h, spin the filtrate to dryness, then add 8 parts by weight of ethyl acetate for extraction, repeat the ethyl acetate extraction process three times, then combine the ethyl acetate layer solutions, add 12 parts by weight of anhydrous potassium carbonate and spin dry, to obtain the formula ( 1) The compound, that is, m-anthraoxybenzaldehyde;

[0027]

[0028] 2) Dissolve 5 parts by weight of m-anthraoxybenzaldehyde in 15 parts by weight of absolute ethanol, and add 3 parts of thiosemicarbazide, reflux and stir at 65°C for 6 hours to obtain a purple solution, spin dry and add ...

Embodiment 2

[0036] The method for preparing titanium dioxide nanotubes with antibacterial and anticancer properties in this scheme includes the following steps:

[0037] 1) Dissolve 3 parts by weight of m-carboxybenzaldehyde in 8 parts by weight of toluene, add 5 parts by weight of 1-(9-anthryl)ethanol, then add 0.5 parts by weight of sulfuric acid with a concentration of 98%, and heat to 100°C and stir to reflux For 1h, spin the filtrate to dryness, then add 5 parts by weight of ethyl acetate for extraction, repeat the ethyl acetate extraction process twice, then combine the ethyl acetate layer solutions, add 10 parts by weight of anhydrous potassium carbonate and spin dry to obtain the formula ( 1) The compound, that is, m-anthraoxybenzaldehyde;

[0038]

[0039] 2) Dissolve 4 parts by weight of m-anthraoxybenzaldehyde in 10 parts by weight of absolute ethanol, and add 1 part of thiosemicarbazide, reflux and stir at 60°C for 5 hours to obtain a purple solution, spin dry and add 5 parts by we...

Embodiment 3

[0047] The method for preparing titanium dioxide nanotubes with antibacterial and anticancer properties in this scheme includes the following steps:

[0048] 1) Dissolve 5 parts by weight of m-carboxybenzaldehyde in 15 parts by weight of toluene, add 15 parts by weight of 1-(9-anthryl)ethanol, then add 1.5 parts by weight of sulfuric acid with a concentration of 98%, and heat to 120°C and stir to reflux 3h, spin the filtrate to dryness, then add 10 parts by weight of ethyl acetate for extraction, repeat the ethyl acetate extraction process 4 times, then combine the ethyl acetate layer solutions, add 15 parts by weight of anhydrous potassium carbonate and spin-dry to obtain the formula ( 1) The compound, that is, m-anthraoxybenzaldehyde;

[0049]

[0050] 2) Dissolve 10 parts by weight of m-anthraoxybenzaldehyde in 20 parts by weight of absolute ethanol, and add 5 parts of thiosemicarbazide, reflux and stir at 70°C for 8 hours to obtain a purple solution, spin dry and add 10 parts b...

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Abstract

The invention discloses a method for preparing a titanium dioxide nanotube with antibacterial and anti-cancer properties. The method comprises the following steps that 1, an iridium complex is prepared; 2, 0.1-0.6 part by weight of cyclodextrin is dissolved in 3.5-20 parts by weight of water, even stirring is conducted, 0.5-1.5 parts by weight of titanium dioxide nanotube is added, and soaking is conducted for 20-60 min; 3, 0.2-1.2 parts by weight of iridium complex is added, and ultrasonication is conducted for 30-60 min at 15-30 kHz; 4, the titanium dioxide nanotube is taken out and dried. According to the method for preparing the titanium dioxide nanotube with the antibacterial and anti-cancer properties, by means of the action of the cyclodextrin and the iridium complex on the titanium dioxide nanotube, the titanium dioxide nanotube has good antibacterial and anti-cancer properties, the surface of the titanium dioxide nanotube facilitates growth of bone cells, the morbidity of complications caused by the titanium dioxide nanotube in an osseointegration operation is decreased, and a safer and more reliable material is provided for the osseointegration operation.

Description

Technical field [0001] The invention relates to the technical field of materials for osseointegration surgery, and more specifically to a method for preparing titanium dioxide nanotubes with antibacterial and anticancer properties. Background technique [0002] α-Cyclodextrin is a kind of macrocyclic compound formed by connecting 6 D-glucopyranose units end to end through α-1,4 glycosidic bonds. The inside of the molecule is a "V"-shaped hydrophobic cavity, which shows a unique molecular recognition ability. Titanium dioxide nanotubes can promote the generation of osteoblasts, and have shown great potential and advantages in the application of implants. However, a serious problem is the related bacterial infection, which has led to the failure of a large number of transplant operations. How to obtain better performance titanium dioxide nanotube materials has become a research direction with great scientific and application significance. In our research, we found that some irid...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/20A61L27/54
CPCA61L27/06A61L27/20A61L27/54A61L2300/224A61L2300/404A61L2300/416C08L5/16
Inventor 李培源苏炜霍丽妮陈睿
Owner 嘉兴慧泉生物科技有限公司
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