trpc3 antigen polypeptide and anti-trpc3 monoclonal antibody
A monoclonal antibody and antigen polypeptide technology, applied in the field of cell engineering, can solve the problem of no immunogenic antigen polypeptide, etc., and achieve the effect of easy human processing and quality control, single biological activity and high uniformity
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Embodiment 1
[0026] Embodiment 1, TRPC3 antigen polypeptide design
[0027] TRPC3 antigen polypeptide YFTYARDKWLPSDPQ (SEQ ID NO: 1)
[0028] The above-mentioned TRPC3 antigen polypeptide α -spiral, β -Turn angle, hydrophilicity and antigenic index are detected, and its detection result is: the antigenic index prediction of the TRPC3 antigenic polypeptide provided by the present invention is 0.995, and revealing predictive value is 1.000, and flexibility predictive value is 1.003, and β-rotation angle predictive value is 1.080, B Cell epitope prediction is better. That is, the TRPC3 antigen polypeptide α -spiral, β -Turning angle, hydrophilicity and antigenic index are all in line with the results of B cell epitope analysis, among which the antigenic index of TRPC3 antigenic polypeptide has a significant advantage, see the results figure 1 shown.
Embodiment 2
[0029] Embodiment 2, the preparation of the anti-TRPC3 monoclonal antibody
[0030] 1. Test objects: 4 healthy BALB / c mice were selected, and the age of the mice was 6-8 weeks.
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