Multifunctional gadolinium-containing hollow mesoporous Prussian blue nano-diagnosis agent and its preparation method and application

A Prussian blue and hollow mesoporous technology, applied in the field of nanomaterials and biomedical materials, can solve the problems that photoacoustic imaging and photothermal therapy cannot be realized, contrast agents cannot be adjusted by near-infrared absorption, and cannot be used as sensitive chemical probes. Achieve excellent photothermal conversion performance, good clinical application prospects, and improve the efficiency of diagnosis and treatment

Active Publication Date: 2019-01-29
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Chinese patent CN102397562A discloses a kind of Gd loaded by Prussian blue 3+ Chinese patent CN103449477A discloses a Prussian blue nano-material contrast agent containing gadolinium, but in these contrast agents, gadolinium is only adsorbed in Prussian blue, and Prussian blue particles do not have cavities and mesoporous pores, so they cannot be loaded with anti- cancer drugs, etc.
In addition, these contrast agents cannot effectively adjust their near-infrared absorption, not only cannot achieve more efficient photoacoustic imaging and photothermal therapy, but also cannot be used as chemical probes with adjustable sensitivity.

Method used

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  • Multifunctional gadolinium-containing hollow mesoporous Prussian blue nano-diagnosis agent and its preparation method and application
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  • Multifunctional gadolinium-containing hollow mesoporous Prussian blue nano-diagnosis agent and its preparation method and application

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preparation example Construction

[0043] In one embodiment, the preparation method of HGPB nanoparticles of the present invention comprises the following steps:

[0044] a) The gadolinium source, the organic macromolecular protective agent with good biocompatibility and reducibility and the acid and the iron source, the organic macromolecular protective agent with good biocompatibility and reducibility and the acid are fully mixed at room temperature;

[0045] b) adding the mixed gadolinium source solution dropwise to the iron source solution, and continuing magnetic stirring;

[0046] c) transfer the solution to a certain temperature environment for processing;

[0047] d) 13000rpm / min, 10 minutes centrifugation collection to obtain gadolinium-containing Prussian blue nanoparticles;

[0048] e) A certain mass of the above nanoparticles and a certain concentration of acid and an organic polymer protective agent with good biocompatibility and reduction are fully mixed, placed in an oven at a certain temperatur...

Embodiment 1

[0068] Preparation of monodisperse, uniform particle size mesoporous Prussian blue nanoparticles:

[0069]a) 45mg of gadolinium nitrate, 1g of polyvinylpyrrolidone and hydrochloric acid solution with a concentration of 0.01mol / L and 33mg of potassium ferricyanide, 1g of polyvinylpyrrolidone and 0.01mol / L of hydrochloric acid solution are fully mixed at room temperature respectively;

[0070] b) The mixed gadolinium source solution was added dropwise to the iron source solution at a rate of 40ml / h, and the magnetic stirring was continued for 3h;

[0071] c) Transfer the solution to an oven at 80°C for 24h;

[0072] d) 13000rpm / min, 10 minutes centrifugation collection to obtain gadolinium-containing Prussian blue nanoparticles;

[0073] e) The above-mentioned nanoparticles of a certain quality and a certain concentration of acid are fully mixed, placed in an oven at a certain temperature, etched for a certain period of time, 13000 rpm / min, and centrifuged for 10 minutes to obt...

Embodiment 2

[0078] Preparation of gadolinium-containing hollow mesoporous Prussian blue nanoparticles with iron-gadolinium ratio of 200:1:

[0079] a) 45mg of gadolinium nitrate, 1g of polyvinylpyrrolidone and a hydrochloric acid solution with a concentration of 0.01mol / L and 33mg of potassium ferricyanide, 1g of polyvinylpyrrolidone and 2mol / L of hydrochloric acid solution are fully mixed at room temperature respectively;

[0080] b) The mixed gadolinium source solution was added dropwise to the iron source solution at a rate of 40ml / h, and the magnetic stirring was continued for 3h;

[0081] c) Transfer the solution to an oven at 80°C for 24h;

[0082] d) 13000rpm / min, 10 minutes centrifugation collection to obtain gadolinium-containing Prussian blue nanoparticles;

[0083] e) The above-mentioned nanoparticles of a certain quality and a certain concentration of acid are fully mixed, placed in an oven at a certain temperature, etched for a certain period of time, 13000 rpm / min, and cent...

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Abstract

The invention relates to multifunctional gadolinium-contained hollow mesoporous Prussian-blue nanometer treatment agent and a preparation method and application thereof. The nanometer treatment agent is gadolinium-contained Prussian-blue nanometer particles which have mesopores and are hollow inside, wherein the molar ratio of iron to gadolinium is (0.8-200) to 1. The hollow mesoporous nanometer treatment agent is good in biocompatibility, T1 weighted magnetic resonance imaging performance is outstanding, and the nanometer treatment agent has high absorption and outstanding photothermal conversion performance in a near-infrared area and is improved in imaging and tumor treatment compared with other Prussian-blue nanometer particles.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and the field of biomedical materials, in particular to a gadolinium-containing hollow mesoporous Prussian blue (HGPB) nanoparticle with excellent nuclear magnetic resonance imaging (MRI), photoacoustic imaging and photothermal conversion properties, as A multifunctional nano-diagnostic agent for realizing tumor hyperthermia, chemotherapy and other treatments under the guidance of multimodal imaging and a preparation method thereof. Background technique [0002] In recent years, the incidence of malignant tumors in my country has shown a significant growth trend. Malignant tumors have surpassed cardiovascular diseases and become the leading cause of death for urban residents, seriously threatening human life and health, and bringing great burden and suffering to society, families and individuals. The international gold standard for the treatment of malignant tumors is early detection and ea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/10A61K49/18A61K49/00A61K41/00A61K47/32A61K47/36A61K47/04A61P35/00
CPCA61K41/0004A61K47/02A61K47/32A61K47/36A61K49/0002A61K49/10A61K49/1824
Inventor 蔡晓军陈航榕施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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