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Polyethylene material modified by curcumin derivatives and its preparation method and application

A technology of curcumin derivatives and polyethylene, applied in medical science, prostheses, catheters, etc., can solve the problems of patient infection, lack of biocompatibility, bacterial invasion, etc., to avoid infection, improve biocompatibility, The effect of easy access to raw materials

Active Publication Date: 2018-06-29
惠州洋瑞印刷包装有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of polyethylene as a medical material often faces problems such as lack of biocompatibility and bacterial invasion, leading to postoperative infection problems in patients

Method used

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  • Polyethylene material modified by curcumin derivatives and its preparation method and application
  • Polyethylene material modified by curcumin derivatives and its preparation method and application
  • Polyethylene material modified by curcumin derivatives and its preparation method and application

Examples

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Effect test

example 1

[0027] A polyethylene material, the surface of the polyethylene material is modified with curcumin derivatives.

[0028] The structural formula of described curcumin derivative is:

[0029]

[0030] The chemical name of the curcumin derivative is: 1,7-bis[2-(3-methylthienyl)]-1,6-heptadiene-3,5-dione, the curcumin derivative The molecular formula is: C 17 h 16 o 2 S 2 , the relative molecular weight of the curcumin derivative is: 316.433;

[0031] Its physical and chemical properties are: orange crystals, easily soluble in water and organic solvents, and its hydrogen nuclear magnetic resonance spectrum data is 1H NMR (CDCl3) δ: 2.39 (6H, s), 5.74 (1H, s), 6.38 (2H, dd, J=15.4Hz), 6.91(2H,t), 7.29(2H,d), 7.85(2H,dd)ppm.

[0032] The preparation method of described curcumin derivative comprises:

[0033] Dissolve 3-methylthiophene-2-carbaldehyde and tributyl borate in ethyl acetate, stir at room temperature for 5 minutes, then add acetylacetone and boron oxide, continu...

example 2

[0042] A polyethylene material, the surface of the polyethylene material is modified with curcumin derivatives.

[0043] The structural formula of described curcumin derivative is:

[0044]

[0045] The chemical name of the curcumin derivative is: 1,7-bis[2-(3-methylthienyl)]-1,6-heptadiene-3,5-dione, the curcumin derivative The molecular formula is: C 17 h 16 o 2 S 2 , the relative molecular weight of the curcumin derivative is: 316.433.

[0046] The preparation method of described curcumin derivative comprises:

[0047]Dissolve 3-methylthiophene-2-carbaldehyde and tributyl borate in ethyl acetate, stir at room temperature for 3 minutes, then add acetylacetone and boron oxide, continue stirring at room temperature for 25 minutes, add n-butylamine, and stir for 3 hours After stopping the stirring, let stand for 10 hours, add hydrochloric acid, stir at 55°C for 0.5 hours, let stand to separate layers, separate the organic phase and the water phase, extract the water ph...

example 3

[0056] A polyethylene material, the surface of the polyethylene material is modified with curcumin derivatives.

[0057] The structural formula of described curcumin derivative is:

[0058]

[0059] The chemical name of the curcumin derivative is: 1,7-bis[2-(3-methylthienyl)]-1,6-heptadiene-3,5-dione, the curcumin derivative The molecular formula is: C 17 h 16 o 2 S 2 , the relative molecular weight of the curcumin derivative is: 316.433.

[0060] The preparation method of described curcumin derivative comprises:

[0061] Dissolve 3-methylthiophene-2-carbaldehyde and tributyl borate in ethyl acetate, stir at room temperature for 8 minutes, then add acetylacetone and boron oxide, continue stirring at room temperature for 35 minutes, add n-butylamine, and stir for 5 hours , stop stirring and let stand for 14 hours, add hydrochloric acid, stir at 65°C for 1.5 hours, stand to separate layers, separate the organic phase and the water phase, extract the water phase with eth...

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Abstract

The invention discloses a polyethylene material, the surface of the polyethylene material is modified with curcumin derivatives. The structural formula of the curcumin derivative is: the invention also discloses the preparation method and application of the polyethylene material. The invention combines curcumin derivatives with excellent antibacterial effect on the surface of polyethylene, so that the obtained polyethylene material modified by curcumin derivatives has strong antibacterial ability.

Description

technical field [0001] The invention relates to polyethylene modified by curcumin derivatives and its preparation method and application. More specifically, the present invention relates to curcumin derivative-modified polyethylene obtained by utilizing the recognition function of curcumin derivatives on ovalbumin, as well as its preparation method and application. Background technique [0002] With the development of science and technology, medical materials have played an increasingly important role. Polyethylene is widely used in the pharmaceutical industry as artificial blood vessels, catheters and other materials due to its non-toxic, chemical resistance and other advantages. However, the use of polyethylene as a medical material often faces problems such as lack of biocompatibility and bacterial invasion, leading to postoperative infection in patients. Recently, researchers have focused on improving polyethylene's antibacterial and other capabilities. How to obtain ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/16A61L27/22A61L29/16A61L29/04
Inventor 李培源苏炜霍丽妮陈睿
Owner 惠州洋瑞印刷包装有限公司
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