Piperacillin sodium and sulbactam sodium medicine composition
A technology of piperacillin sodium and sulbactam sodium, applied in the directions of drug delivery, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve problems such as hidden safety hazards, influence on curative effect, unsatisfactory dissolution rate, etc., and achieve product safety. High performance and antibacterial activity
Inactive Publication Date: 2016-04-13
邓爱相
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Problems solved by technology
[0003] Sulbactam sodium is an irreversible competitive β-lactamase inhibitor. Piperacillin belongs to penicillin drugs and is easily hydrolyzed by β-lactamase. In order to enhance the activity of piperacillin, piperacillin and β-lactamase have been clinically developed. -Lactamase inhibitors are used in combination to achieve a synergistic effect, but the dissolution rate is unsatisfactory
During the production process, the two raw powders of piperacillin and sulbactam sodium are physically mixed, and the dissolution rate is not ideal, which affects the curative effect in clinical use and has potential safety hazards
Method used
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Effect test
Embodiment 1
[0016] Weigh 1000.0 g of piperacillin sodium and 250.0 g of sulbactam sodium, and pulverize them in a jet mill until more than 95% of the particles have a particle size of ≤120 mm.
Embodiment 2
[0018] Weigh 1000.0 g of piperacillin sodium and 333.0 g of sulbactam sodium, and pulverize them in a jet mill until more than 95% of the particles have a particle size of ≤100 mm.
Embodiment 3
[0020] Weigh 1000.0 g of piperacillin sodium and 500.0 g of sulbactam sodium, and pulverize them in a jet mill until more than 95% of the particles have a particle size of ≤110 mm.
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Abstract
The invention discloses a piperacillin sodium and sulbactam sodium medicine composition. The piperacillin sodium and sulbactam sodium medicine composition comprises active pharmaceutical ingredients of piperacillin sodium micro powder and sulbactam sodium micro powder, and the d95 of the piperacillin sodium micro powder and sulbactam sodium micro powder ranges from 120 [mu]m to 80 [mu]m. Experiments prove that the medicine composition is high in antibacterial activity, good in re-dissolution performance and high in product safety.
Description
technical field [0001] The invention relates to the field of medicines, in particular to a compound antibiotic, in particular to a piperacillin sodium sulbactam sodium pharmaceutical composition. Background technique [0002] Piperacillin, also known as oxygen piperazine penicillin, its English name is PiPRAcil, PiPRL, Tazocin, Piperacillin. Chemical name (2S,5R,6R)-3.3-Dimethyl-6-[(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)phenylacetamido]-7-oxo Generation-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Piperacillin is a semi-synthetic penicillin antibiotic with broad-spectrum antibacterial activity. Piperacillin is effective against Enterobacteriaceae such as Escherichia coli, Proteus, Serratia, Klebsiella, Enterobacter, Citrobacter, Salmonella and Shigella, as well as Pseudomonas aeruginosa Other Gram-negative bacteria, such as Monas, Acinetobacter, Haemophilus influenzae, and Neisseria, all have good antibacterial effects. Piperacillin also has certain antibacte...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K31/496A61K9/14A61P31/04A61K31/43
CPCA61K31/496A61K9/0019A61K9/14A61K31/43A61K2300/00
Inventor 邓爱相
Owner 邓爱相