A method for preparing high bulk density flavored nucleotide disodium mixed crystals

Abstract

The invention relates to a method for preparing high-bulk-density flavor nucleotides disodium mixed crystal. The method comprises the following steps: adding a flavor nucleotides disodium crude product into water, keeping temperature constant at 25-45 DEG C, stirring and dissolving until clear; adding a certain amount of ethanol, adding I+G seed crystal into a metastable zone, growing crystal and continuously adding ethanol drop by drop at a certain rate; and filtering and washing, drying at normal temperature and at normal pressure for 1-3 h so as to obtain I+G mixed crystal. By adjusting key factors such as seed crystal and elution rate, etc., nucleation and growth of crystal are greatly controlled. The prepared I+G product is rodlike crystal, size distribution is d(50)=200-450 microns, and bulk density is 0.76-0.86 g / ml. The product has good fluidity. The product is applied in the field of food additives. By molecular mixing of IMP and GMP, flavor developing effect of the product is enhanced. The I+G mixed crystal's good form meets international market demand. The production technology is simple and is less time-consuming. By the technology, it is easy to realize industrial production.

Description

technical field [0001] The invention relates to the field of refining food additives, in particular to a method for preparing high-bulk-density taste-flavored nucleotide disodium mixed crystals through solution co-crystallization technology. Background technique [0002] Disodium 5'-ribonucleotide (I+G for short) is disodium 5'-inosinate (IMP for short) and disodium 5'-guanylate (I+G for short). '-guanylate (GMP for short) crystals or mixtures, which need to be mixed according to the content ratio stipulated by the state (the content of IMP and GMP each accounts for 48.0% to 52.0%). The chemical formula of IMP is C 10 h 11 N 4 Na 2 o 8 P, with a molecular weight of 392.17, is a colorless to white crystal or white crystalline powder, containing about 7.5 molecules of crystal water. GMP chemical formula is C 10 h 12 N 5 Na 2 o 8 P, is a colorless to white crystal or crystalline powder, containing about 7 molecules of crystal water. Both IMP and GMP are nucleotide d...

AI Technical Summary

Problems solved by technology

The initial precipitation of crystals in this method is achieved by continuously adding ethanol to dissolve and crystallize, and the crystallization nucleation is not strictly controlled. The solubility of 5'-flavored nucleotides in pure water system decreases rapidly with the increase of alcohol content, which is easy to cause explosive nucleation. , The product crystal is finely crushed

After cooling down to 20-40°C to precipitate a large number of crystals, raise the temperature of the feed liquid to 65°C to eliminate fine crystals. The disadvantage of this method is that the temperature rise is too large (~35°C), and a lot of energy is consumed.

Since the nucleation of crystallization is not strictly controlled, the subsequent temperature rise to eliminate fine grains cannot solve the fundamental problem of small particle size, and the product crystals are only about 60 μm, see the appendix of its manual Figure 1-5 , the crystal is flaky, the product has low bulk density, poor shape, and easy to agglomerate

Can not well meet the preparation requirements of high-quality flavoring agent

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