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Natural medicinal material extract and preparation method thereof

A technology of natural medicines and extracts, used in drug combinations, pharmaceutical formulations, antipyretics, etc., can solve the problems of large gastrointestinal reactions, expensive western medicines, poor compliance of elderly patients, etc., to achieve no drug resistance, treatment Effects of Osteoarthritis

Inactive Publication Date: 2016-05-04
LIAONING INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treatment is currently mainly based on non-steroidal anti-inflammatory drugs, but the price of western medicine is relatively expensive, long-term use causes gastrointestinal reactions, and elderly patients have poor compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] S1, the preparation of celery seed extract extract:

[0030] S11. The aqueous solution after celery seed crushing is first separated by a composite polyvinyl chloride ultrafiltration membrane, and the permeate is collected, and then the extract is concentrated to 10% of the original volume with a nanofiltration membrane with a molecular weight cut-off of 300, and collected and concentrated liquid;

[0031] S12. Pass the obtained concentrated solution through the macroporous resin column at a flow rate of 2BV / h. After the dynamic adsorption is saturated, rinse the above-mentioned macroporous resin column with deionized water at a flow rate of 5BV / h until the effluent is colorless, and then use volume The organic solvent with a fraction of 40% is eluted at a flow rate of 8BV / h, the organic solvent eluate is collected, and finally the collected eluate is concentrated under reduced pressure to obtain an extract;

[0032] S13. Dissolve the extract in water and pass through ...

Embodiment 2

[0041] S1, the preparation of celery seed extract extract:

[0042] S11. The aqueous solution after celery seed crushing is first separated by a composite polyvinyl chloride ultrafiltration membrane, and the permeate is collected, and then the extract is concentrated to 10% of the original volume with a nanofiltration membrane with a molecular weight cut-off of 300, and collected and concentrated liquid;

[0043] S12. Pass the obtained concentrated solution through the macroporous resin column at a flow rate of 6BV / h. After the dynamic adsorption is saturated, rinse the above-mentioned macroporous resin column with deionized water at a flow rate of 10BV / h until the effluent is colorless, and then use volume The organic solvent with a fraction of 100% is eluted at a flow rate of 12BV / h, the organic solvent eluate is collected, and finally the collected eluate is concentrated under reduced pressure to obtain an extract;

[0044] S13. Dissolve the extract in water and pass throu...

Embodiment 3

[0053] S1, the preparation of celery seed extract extract:

[0054] S11. The aqueous solution after celery seed crushing is first separated by a composite polyvinyl chloride ultrafiltration membrane, and the permeate is collected, and then the extract is concentrated to 10% of the original volume with a nanofiltration membrane with a molecular weight cut-off of 300, and collected and concentrated liquid;

[0055] S12, passing the obtained concentrated solution through the macroporous resin column at a flow rate of 4BV / h, after the dynamic adsorption is saturated, rinse the above-mentioned macroporous resin column with deionized water at a flow rate of 7.5BV / h until the effluent is colorless, and then use The organic solvent with a volume fraction of 70% is eluted at a flow rate of 10BV / h, the organic solvent eluate is collected, and finally the collected eluate is concentrated under reduced pressure to obtain an extract;

[0056] S13. Dissolve the extract in water and pass th...

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Abstract

The invention discloses a natural medicinal material extract and a preparation method thereof. The extract is prepared from the following components in parts by weight: 42-62 parts of celery seed extract, 15-25 parts of oxygraphis glacialis extract, 6-18 parts of fructus forsythiae extract and 6-18 parts of maca extract. According to the preparation method, celery seed extract, oxygraphis glacialis extract and maca extract which have relatively high purities are obtained by a special process, and are mixed with fructus forsythiae extract in an optimized ratio. The natural medicinal material extract can be used for effectively treating osteoarthritis, and cannot produce drug resistance.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extraction mixture, in particular to a natural medicine extract and a preparation method thereof. Background technique [0002] Knee osteoarthritis, also known as knee degenerative arthritis, is a disease that is more common in the elderly and is characterized by degenerative changes in articular cartilage. It is aseptic, chronic, and progressively invades bone and includes synovium and joint capsule. All-round, multi-level, and varying degrees of chronic inflammatory arthropathy in other structures of the joint. Epidemiological surveys show that the incidence rate among people aged 55 to 64 reaches 40%. With the increase of the aging population in the world, the incidence rate is also increasing year by year. [0003] The exact etiology and pathogenesis of osteoarthritis have not yet been fully elucidated. The current treatment methods are mainly aimed at relieving pain, improving function, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61P19/02A61P29/00
CPCA61K36/185A61K36/23A61K36/31A61K36/634A61K2236/15A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 楚冬海贺凤伟黄占波
Owner LIAONING INST OF SCI & TECH
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