Polylactic acid/polycaprolactone/polypropylene composite pelvic floor patch and preparation method thereof

Abstract

The invention relates to a polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch and a preparation method thereof. The composite pelvic floor patch is a three-layer coated patch consisting of an upper coating layer, a lower coating layer and a middle support layer, wherein the coating layers are degradable films, and the support layer is a warp-knitted mesh patch. The preparation method comprises the following steps: knitting polypropylene monofilaments to obtain a polypropylene warp-knitted mesh patch, washing and naturally air-drying the polypropylene warp-knitted mesh patch at room temperature, and then performing heat setting, cooling and cutting; mixing polylactic acid and polycaprolactone, dissolving the mixture in a solvent, and performing heating and stirring to obtain a mixed solution; impregnating the polypropylene warp-knitted mesh patch in the mixed solution, taking out and horizontally arranging the polypropylene warp-knitted mesh patch, and performing volatilization and sterilization to obtain the polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch. According to the composite pelvic floor patch and the preparation method thereof, an absorbable material is combined with a nonabsorbable material, and an impregnation and coating forming process is utilized, so that the prepared coated patch has the advantages of small thickness, strong strength, high flexibility and biocompatibility and the like. The method is simple and convenient to implement, and use of an adhesive is not required.

Description

technical field

[0001] The invention belongs to the field of pelvic floor patch and its preparation, in particular to a polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch and a preparation method thereof. Background technique

[0002] Female pelvic floor dysfunction (PFD) is a disease characterized by stress urinary incontinence (SUI), pelvic organ prolapse (POP) and chronic pelvic pain (PPC). gynecological diseases. A large number of studies have shown that pelvic floor mesh is an important pelvic floor tissue replacement, which can replace the weak and damaged pelvic floor fascia tissue. Compared with the traditional hysterectomy method, the mesh has gradually been confirmed in terms of improving the safety of the operation and improving the quality of life of patients [ACHTARIC, HISCOCKR, O'REILLYBA, et al. mesh.IntUrogynecolJPelvicFloorDysfunct,2005,16(5):389-394;LORDHE,TAYLORJD,FINNJC,etal.Arandomizedcontrolledequivalencetrialofshort-termcompl...

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