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Polylactic acid/polycaprolactone/polypropylene composite pelvic floor patch and preparation method thereof

A technology of polycaprolactone and polylactic acid, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve problems such as stiff hand feeling, and achieve the effects of good bonding fastness, improved quality of life, and good biocompatibility

Inactive Publication Date: 2016-05-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the hernia mesh requires greater mechanical properties such as stretching and bursting, the mesh structure is tighter and feels stiffer

Method used

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  • Polylactic acid/polycaprolactone/polypropylene composite pelvic floor patch and preparation method thereof
  • Polylactic acid/polycaprolactone/polypropylene composite pelvic floor patch and preparation method thereof
  • Polylactic acid/polycaprolactone/polypropylene composite pelvic floor patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Preparation of Polypropylene Rhomboid Mesh Patch

[0031] (1) Patch weaving: Use polypropylene monofilament with a diameter of 0.1mm as the raw material, and weave it on a three-bar Raschel warp knitting machine with a machine number of 20E to make a patch with a rhombic mesh structure. The yarn motion numbers are:

[0032] GB1:1-0 / 0-1 / / full wear

[0033] GB2:0-0 / 2-2 / 1-1 / 3-3 / 0-0 / 3-3 / 1-1 / 2-2 / 0-0 / 3-3 / / One wear one empty

[0034] GB3:3-3 / 1-1 / 2-2 / 0-0 / 3-3 / 0-0 / 2-2 / 1-1 / 3-3 / 0-0 / / One wear one empty

[0035] (2) Washing of patches: Gently rinse in cold water to remove surface impurities, and dry naturally at room temperature.

[0036] (3) Heat setting of the patch: the heat setting temperature is 130°C, and the heat setting time is 15 minutes.

[0037] 2. Configuration of polylactic acid / polycaprolactone solution

[0038]Weigh 0.84g of polylactic acid granules and 0.36g of polycaprolactone granules into a screw-top glass bottle with a sealed cover, mix the DMC and DMF sol...

Embodiment 2

[0049] 1. Preparation of polypropylene hexagonal mesh patch

[0050] (1) Patch weaving: use polypropylene monofilament with a diameter of 0.1mm as the raw material, and weave it on a three-bar Raschel warp knitting machine with a machine number of 16E to make a patch with a hexagonal mesh structure. The yarn motion numbers are:

[0051] GB1: 2-3 / 2-1 / 2-3 / 1-0 / 1-2 / 1-0 / / 1 wear 1 empty

[0052] GB2: 1-1 / 1-0 / 1-0 / 2-2 / 2-3 / 2-3 / / 1 empty 1 wear

[0053] GB3: 1-0 / 1-2 / 1-0 / 2-3 / 2-1 / 2-3 / / 1 wear 1 empty

[0054] (2) Washing of patches: Gently rinse in cold water to remove surface impurities, and dry naturally at room temperature.

[0055] (3) Heat setting of the patch: the heat setting temperature is 130°C, and the heat setting time is 10 minutes.

[0056] 2. Configuration of polylactic acid / polycaprolactone solution

[0057] Weigh 0.84g of polylactic acid granules and 0.36g of polycaprolactone granules into a screw-top glass bottle with a sealed cover, mix the DMC and DMF solutions evenl...

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Abstract

The invention relates to a polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch and a preparation method thereof. The composite pelvic floor patch is a three-layer coated patch consisting of an upper coating layer, a lower coating layer and a middle support layer, wherein the coating layers are degradable films, and the support layer is a warp-knitted mesh patch. The preparation method comprises the following steps: knitting polypropylene monofilaments to obtain a polypropylene warp-knitted mesh patch, washing and naturally air-drying the polypropylene warp-knitted mesh patch at room temperature, and then performing heat setting, cooling and cutting; mixing polylactic acid and polycaprolactone, dissolving the mixture in a solvent, and performing heating and stirring to obtain a mixed solution; impregnating the polypropylene warp-knitted mesh patch in the mixed solution, taking out and horizontally arranging the polypropylene warp-knitted mesh patch, and performing volatilization and sterilization to obtain the polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch. According to the composite pelvic floor patch and the preparation method thereof, an absorbable material is combined with a nonabsorbable material, and an impregnation and coating forming process is utilized, so that the prepared coated patch has the advantages of small thickness, strong strength, high flexibility and biocompatibility and the like. The method is simple and convenient to implement, and use of an adhesive is not required.

Description

technical field [0001] The invention belongs to the field of pelvic floor patch and its preparation, in particular to a polylactic acid / polycaprolactone / polypropylene composite pelvic floor patch and a preparation method thereof. Background technique [0002] Female pelvic floor dysfunction (PFD) is a disease characterized by stress urinary incontinence (SUI), pelvic organ prolapse (POP) and chronic pelvic pain (PPC). gynecological diseases. A large number of studies have shown that pelvic floor mesh is an important pelvic floor tissue replacement, which can replace the weak and damaged pelvic floor fascia tissue. Compared with the traditional hysterectomy method, the mesh has gradually been confirmed in terms of improving the safety of the operation and improving the quality of life of patients [ACHTARIC, HISCOCKR, O'REILLYBA, et al. mesh.IntUrogynecolJPelvicFloorDysfunct,2005,16(5):389-394;LORDHE,TAYLORJD,FINNJC,etal.Arandomizedcontrolledequivalencetrialofshort-termcompl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/58
CPCA61L27/16A61L27/26A61L27/58A61L2430/02C08L67/04C08L23/12
Inventor 鲁瑶张佩华王聪儿陈南梁童晓文付少举王建军邓旺欧阳一芹吴亚平
Owner DONGHUA UNIV
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