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Penetration enhancer for cosmetics

A technology for cosmetics and penetration enhancers, which is applied in the field of penetration enhancers for cosmetics, can solve the problems of long penetration enhancement time lag and short onset time, and achieves reduction of penetration enhancement time lag, short onset time, and improvement of penetration enhancement rate. Effect

Active Publication Date: 2018-12-18
SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0006] This application provides a penetration enhancer for cosmetics, which overcomes the defects in the prior art that the penetration enhancer is irritating to the skin, has a long time lag in promoting penetration, and will bring safety hazards to users. It is safe, non-irritating, and effective. The time is short, the penetration-promoting efficiency is high, and it only acts on the stratum corneum tissue, avoiding the advantages of excessive penetration-promoting effect bringing safety hazards to the human body

Method used

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  • Penetration enhancer for cosmetics

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preparation example Construction

[0027] The preparation method of penetration enhancer for cosmetics:

[0028] 1) Take a certain amount of natural Chinese herbal extract components and add them to 0.05-0.07mol / L citrate buffer (pH7.5-8.5), and then set the molar ratio of natural Chinese herbal extract components to dextran monomer at 5 : 1-10: 1 Add dextran, control the temperature of 60-70° C. to stir and react for 7-10 hours, freeze and dry the reaction solution, and obtain the natural Chinese herbal medicine extract component modified by dextran.

[0029] 2) Add 60-80% natural Chinese herbal medicine extract components and 20-40% HEPES into the container by weight percentage, stir evenly, and prepare the cosmetic penetration enhancer of the present application.

[0030] Test Methods: The penetration enhancing effect of penetration enhancer was investigated by Franze diffusion cell method.

[0031] Functional ingredients: sodium hyaluronate (HA), molecular weight 600,000-700,000.

[0032] Experimental...

Embodiment 1-5

[0044] First prepare the penetration enhancer according to the preparation method of the penetration enhancer for cosmetics and the formula in Table 1, and add it to the cosmetic at a ratio of 0.02% to 0.5%, and compare it with the cosmetic without any penetration enhancer (blank control group) Compared with the cosmetics added with 2% azone penetration enhancer (azone penetration enhancer group), the penetration enhancement effect of the cosmetics was investigated by the Franze diffusion cell method, and the test results are shown in Table 2.

[0045] Table 2 Comparative test results

[0046]

[0047] Note: * indicates that the accumulated penetration amount cannot be detected.

[0048]It can be seen from Table 2 that compared with the blank control group and the azone penetration enhancer group, the cosmetics added with natural Chinese herbal medicine penetration enhancer had a shorter onset time, and obvious penetration enhancement effect had been produced in 10 minutes,...

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Abstract

The invention provides a penetration enhancer for cosmetics. The penetration enhancer comprises 60-80wt% of a natural Chinese herbal medicine extract component and 20-40wt% of sodium hydroxyethylpiperazine ethane sulfonic acid sodium, the natural Chinese herbal medicine extract component comprises at least one of tetrahydropiperine, cinnamaldehyde, eugenol and tanshinone, and beta-1,3-glucan is grafted with the natural Chinese herbal medicine extract component to carry out modification treatment. The natural Chinese herbal medicine extract component in the penetration enhancer for cosmetics has good endophilicity to skins, is safe and non-irritant, increases the penetration promotion effect through glucan modification, also can control just action of the penetration promotion effect on stratum corneum, and improves the use safety of the cosmetics. The penetration enhancer for cosmetics has the advantages of short onset time, realization of the penetration promotion time lag being shorter than 10min, small dosage, and high penetration promotion rate, and the penetration promotion rate of the penetration enhancer provided by the invention is 4 or more times that of traditional azone penetration enhancers when the dosage of the penetration enhancer provided by the invention is 1 / 20 of the dosage of the traditional azone penetration enhancers.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a penetration enhancer for cosmetics. Background technique [0002] Cosmetics generally add a lot of nutrients. If the nutrients cannot be completely absorbed by the skin, it will cause excess nutrition on the skin surface, leading to "skin oxidation", premature aging, and a large number of bacteria on the skin surface, which will cause skin infections. Therefore, it is necessary to add transdermal absorption enhancers (penetration enhancers) in cosmetics to promote the transdermal absorption of various functional components. [0003] In recent years, conventional penetration enhancers such as dimethyl sulfoxide, dimethylamide, azone, and oleic acid have been widely used. However, this type of penetration enhancer will cause strong irritation to the skin, and the time lag of penetration enhancement is long, which affects the absorption effect. At the same time, conventional penetration...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/63A61K8/49A61K8/33A61Q19/00
CPCA61K8/33A61K8/49A61K8/494A61K8/63A61K2800/10A61Q19/00
Inventor 王宇朱广东陈占熊俊超
Owner SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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