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Oseltamivir phosphate oral solution and preparation method thereof

A technology of oseltamivir phosphate and Wei oral liquid, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the requirements of high cost, oral liquid production equipment and process conditions Advanced problems, to achieve the effect of simple preparation method, good clarity and high stability

Inactive Publication Date: 2016-06-08
SHANGHAI TAOHONG CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production equipment and process conditions of oral liquid are relatively high, and the cost is relatively expensive.

Method used

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  • Oseltamivir phosphate oral solution and preparation method thereof
  • Oseltamivir phosphate oral solution and preparation method thereof
  • Oseltamivir phosphate oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The co-solvent is a mixture of sodium carboxymethylcellulose, propylene glycol, D-mannitol and poloxamer 188 in a mass ratio of 1:1:1:1.

[0047] The flavoring agent is aspartame.

[0048] The stabilizer is sodium succinate.

[0049] The preservative is potassium sorbate.

Embodiment 2

[0051] Prepare by the method of embodiment 1.

[0052] The co-solvent is replaced by a mixture of propylene glycol, D-mannitol and poloxamer 188 in a mass ratio of 1:1:1.

Embodiment 3

[0054] Prepare by the method of embodiment 1.

[0055] The co-solvent is replaced by a mixture of sodium carboxymethylcellulose, D-mannitol and poloxamer 188 in a mass ratio of 1:1:1.

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PUM

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Abstract

The invention discloses an oseltamivir phosphate oral solution. The oral solution is prepared from the following raw materials in parts by weight: 0.1 part of oseltamivir phosphate, 0.01-0.02 part of co-solvent, 0.01-0.02 part of a flavoring agent, 0.01-0.02 part of a stabilizing agent, 0.01-0.02 part of preservative and 15-30 parts of water. The invention further provides a method for preparing the oseltamivir phosphate oral solution. The oseltamivir phosphate oral solution has the advantages of good clarity and high stability, and the preparation method is simple and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oseltamivir phosphate preparation and a preparation method thereof, in particular to an oseltamivir phosphate oral liquid and a preparation method thereof. Background technique [0002] Neuraminidase (NA) inhibitors are a class of anti-influenza virus drugs developed in recent years. As a newly developed neuraminidase inhibitor, oseltamivir phosphate is effective against both type A and type B influenza viruses, It is not easy to drug resistance, well tolerated by patients, and has high safety. It is clinically used for the prevention and treatment of influenza. [0003] Oseltamivir (Oseltamivir, used as its phosphate salt) is a therapeutic drug for the prevention and control of influenza pandemics by the World Health Organization and the Ministry of Health of my country, and it is also a national strategic reserve drug for the prevention and control of influenza pande...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/215A61P31/16A61K47/38A61K47/10A61K47/26A61K47/34A61K47/36A61K47/12
CPCA61K9/08A61K9/0053A61K31/215A61K47/10A61K47/12A61K47/26A61K47/36A61K47/38
Inventor 黄毅
Owner SHANGHAI TAOHONG CHEM TECH