Production technology of cycloserine

Abstract

The invention belongs to the field of chemical synthesis, and particularly relates to a production technology of cycloserine. According to the synthesis technology, D-serine is used as a starting material, three reactions of esterification, chlorination and cyclization are performed, and the cycloserine is obtained. The technological process is simple, the yield is high, and the purity is high. During the esterification reaction, diethyl ether is replaced with ethyl acetate, no 8-hydroxyquinoline is added for crude product preparation after the cyclization reaction, and usage of reagent diethyl ether likely to produce toxicity and the dangerous product 8-hydroxyquinoline is avoided. Meanwhile, the synthesis route is short, the cost is low, and the obtained product is stable in yield and controllable in quality.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a production process of cycloserine. Background technique [0002] Cycloserine, also known as D-4-amino-3-isoxazolidinone, is an antibiotic drug that has a good inhibitory effect on Mycobacterium tuberculosis. Because bacteria are not easy to develop drug resistance to it, it is mainly used clinically to treat the infection of drug-resistant Mycobacterium tuberculosis. In addition, studies have found that cycloserine is a special regulator of excitatory amino acid NMDA (N-methyl-D-aspartate) receptors in the central nervous system, and it is also effective in the treatment of psychological diseases such as psychological phobia, depression, and schizophrenia. It has good auxiliary curative effect, and it is also an important intermediate in the synthesis of atypical β-lactam antibiotic Lactivicin. Therefore, cycloserine has broad application prospects and huge marke...

AI Technical Summary

Problems solved by technology

[0007] It can be seen from the above route that the steps of this route are long and need to be split, and the synthesis cost is relatively high

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