A kind of fungal strain with the function of treating Alzheimer's disease and its application
A technology for Alzheimer's disease and strains, applied in the field of microorganisms, can solve the problems of difficulty in obtaining pure optically active compounds, high cost, lack of plant resources, etc. Effect
Active Publication Date: 2019-04-23
陕西仁达康健医药生物科技有限公司
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Problems solved by technology
[0005] The purpose of the present invention is to provide a fungal strain with the function of treating Alzheimer's disease, to solve the bottleneck of plant resource shortage in obtaining huperzine A from plant extraction; and the chemical synthesis steps are cumbersome and expensive, and it is difficult to obtain pure optical activity The compound problem
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[0021] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0022] The invention relates to a fungal strain with the function of treating Alzheimer's disease, which is isolated from the endophytic fungus of wild Huperzia serrata (Huperzia serrata Huperzia family, Huperzia genus), and belongs to Trichoderma harzianum species of Trichoderma genus (Trichoderma harzianum) NSW-V strain has genetic stability after 15 generations in the laboratory, and its amino sequence is shown in SEQ ID NO:1.
[0023] The strain has been preserved in China Ordinary Microorganism Culture Collection Center, a preservation unit designated by the State Intellectual Property Office.
[0024] Biological material deposit information:
[0025] Name: Trichoderma harzianum NSW-V strain
[0026] Deposit number: CGMCC No.12076
[0027] Deposit unit: General Microbiology Center of China Committee for Microorganism Culture Collectio...
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The invention discloses a fungal strain with the function of treating Alzheimer's disease. The fungal strain is isolated from the endophytic fungus of Huperz serrata and belongs to Trichoderma harzianum (Trichoderma harzianum) NSW‑V strain. It has genetic stability after 15 passages in the laboratory, and its amino sequence is shown in SEQ ID NO:1. The fungal strain with the function of treating Alzheimer's disease of the present invention is used as a biological strain for treating Alzheimer's disease, and its excellent high-efficiency expression gene for producing huperzine A is transferred into other model strains, and more can be obtained through genetic modification. In addition, the strains can be further optimized through mutation breeding. The research on it will be of great significance for the industrial production of huperzine A through biosynthesis, the protection of plant resources, the resolution of clinical first-line drug needs, and the reduction of medical expenses for the treatment of Alzheimer's disease.
Description
technical field [0001] The invention belongs to the technical field of microorganisms, and in particular relates to a fungal strain capable of treating Alzheimer's disease, and also relates to the application of the fungal strain. Background technique [0002] Currently, the class of acetylcholinesterase inhibitors dominates the Alzheimer's disease drug market. Huperzine A is a new type of lycopodium monomeric alkaloid isolated from the folk herbal medicine Huperzia serrata. It is a potent and reversible cholinesterase inhibitor with multi-target effects. The inhibitory effect is 3 times that of physostigmine and 30 times that of galantamine, and the peripheral adverse reactions are low. It is one of the clinically preferred drugs for the treatment of Alzheimer's disease. [0003] The development of drugs derived from natural plants has a long history and is full of vitality. Plant extraction to obtain huperzine A is the easiest way, but plant extraction to obtain huperzine...
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IPC IPC(8): C12N1/14A61K36/06A61P25/28C12R1/885
CPCA61K36/06C12N1/14C12N1/145C12R2001/885
Inventor 韩文霞李伟泽韩忠文张寒孙静李妮王琳周永强
Owner 陕西仁达康健医药生物科技有限公司