Hydroxamic acid functionalized polymer/inorganic composite adsorbent for efficiently adsorbing flavonoids and preparation method thereof

A flavonoid compound and inorganic composite technology, which is applied in the direction of chemical instruments and methods, separation methods, combustible gas purification/transformation, etc., can solve the problems of poor reusability, low purity, low extraction rate, etc., and achieve simple purification operation Ease of operation, simple preparation process, and large bonding capacity

Inactive Publication Date: 2018-10-12
ZHONGBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a hydroxamic acid functionalized polymer / inorganic composite adsorption for efficiently adsorbing flavonoids in order to solve the disadvantages of low extraction rate, low purity and poor reusability of materials used in the existing extraction and purification of flavonoids. Agent and preparation method

Method used

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  • Hydroxamic acid functionalized polymer/inorganic composite adsorbent for efficiently adsorbing flavonoids and preparation method thereof
  • Hydroxamic acid functionalized polymer/inorganic composite adsorbent for efficiently adsorbing flavonoids and preparation method thereof
  • Hydroxamic acid functionalized polymer/inorganic composite adsorbent for efficiently adsorbing flavonoids and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Example 1: A hydroxamic acid functionalized polymer / inorganic composite adsorbent that efficiently adsorbs flavonoids, referred to as SHA-PS / SiO 2 , which is composed of micron-sized silica and hydroxamic acid functionalized polymer with hydrogen bond interaction with flavonoids, the structure is as formula (I), its silica particle size is 90 μm, and its salicylic hydroxamic acid bonding rate 12.0%;

[0028] .

[0029] The hydroxamic acid functionalized polymer is two parts of hydroxamic acid functional group and polystyrene, wherein the hydroxamic acid functional group is formed by salicylic hydroxamic acid. Its preparation method is:

[0030] (1) Silica gel particles CMPS / SiO grafted with chloromethylated polystyrene CMPS 2 Preparation: 3.0g of microparticle PS / SiO 2 Add to 40ml CH 2 Cl 2 After soaking in the solvent for 4 hours, add 13.0 ml of 1,4-dichloromethoxybutane, stir evenly, and then add 2.0 ml of catalyst SnCl 4 , after reacting at 25°C for 12 hours...

Embodiment 2

[0035] Example 2: A hydroxamic acid functionalized polymer / inorganic composite adsorbent that efficiently adsorbs flavonoids, referred to as SHA-PS / SiO 2 , composed of micron-sized silica and hydroxamic acid functionalized polymers with hydrogen bond interactions to flavonoids, the structure is the same as that described in Example 1, the silica particle size is 100 μm, and its salicylic hydroxamic acid bond The combined rate is 11.5%.

[0036] The hydroxamic acid functionalized polymer is two parts of hydroxamic acid functional group and polystyrene, wherein the hydroxamic acid functional group is formed by salicylic hydroxamic acid. Its preparation method is:

[0037] (1) Silica gel particles CMPS / SiO grafted with chloromethylated polystyrene CMPS 2 Preparation: 3.0g of microparticle PS / SiO 2 Added to 30ml of CH 2 Cl 2 After soaking in the solvent for 4 hours, add 11 mL of chloromethylation reagent 1,4-dichloromethoxybutane, stir evenly, and then add 1.6 mL of catalyst ...

Embodiment 3

[0041] Example 3: A hydroxamic acid functionalized polymer / inorganic composite adsorbent that efficiently adsorbs flavonoids, referred to as SHA-PS / SiO 2, consisting of micron-sized silicon dioxide and a hydroxamic acid functionalized polymer with hydrogen bond interactions to flavonoids, the structure is the same as that described in Example 1, the particle size of the silicon dioxide is 125 μm, and the salicylic hydroxamic acid The bonding ratio was 11.0%.

[0042] The hydroxamic acid functionalized polymer is two parts of hydroxamic acid functional group and polystyrene, wherein the hydroxamic acid functional group is formed by salicylic hydroxamic acid. Its preparation method is:

[0043] (1) Silica gel particles CMPS / SiO grafted with chloromethylated polystyrene CMPS 2 Preparation: 3.0 g of microparticle PS / SiO 2 Add it into 20mL carbon tetrachloride solvent, soak for 3h, then add 10mL chloromethylation reagent 1,4-dichloromethoxybutane, stir evenly, then add 1.3ml cat...

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Abstract

The invention belongs to the technical field of organic / inorganic functional compound adsorbents and provides a hydroximic acid functionalized polymer / inorganic compound adsorbent capable of efficiently adsorbing flavonoids substances and a preparation method thereof, aiming at overcoming the disadvantages of materials used by existing extraction and purification of the flavonoids substances that the extraction rate is low, the purity is not high and the reusability is poor and the like. The hydroximic acid functionalized polymer / inorganic compound adsorbent is composed of micron-grade silicon dioxide and a hydroximic acid functionalized polymer with a hydrogen bond mutual effect on a flavonoids compound. The hydroximic acid functionalized polymer is composed of two substances including a hydroximic acid functional group and polystyrene, and salicylhydroxamic acid forms the hydroximic acid functional group. The adsorbent has an ultrahigh adsorption property on the flavonoid compound, and the adsorption amount on quercetin reaches 452mg / g; the hydroximic acid functionalized polymer / inorganic compound adsorbent is insoluble, has micron-grade particles and is convenient to separate. In a utilization process, the adsorbent can be regenerated by an alkali solution with an electrolyte and can be repeatedly utilized. The adsorbent provided by the invention has the advantages that a preparation process is simple, performances are stable, the treatment speed is rapid, and purification operation of a flavonoid rough extracting solution in Chinese herbal medicines is simple, convenient and feasible.

Description

technical field [0001] The invention belongs to the technical field of organic / inorganic functional composite adsorbents, and in particular relates to a hydroxamic acid functionalized polymer / inorganic composite adsorbent for efficiently adsorbing flavonoids and a preparation method thereof. Background technique [0002] Flavonoids are an important class of natural organic compounds, which widely exist in vegetables, fruits, forages and medicinal plants in nature, not only in a large number, but also in complex and diverse structures. At present, more than 10,000 flavonoids have been found, with different molecular structures. Flavonoids have broad-spectrum pharmacological activity and low toxicity due to their unique chemical structure. They can scavenge free radicals in organisms, have antioxidant effects, and have enzyme-inhibiting, anti-cancer, anti-bacterial, and anti-viral properties. , anti-inflammation, anti-allergic, anti-diabetic complications and other functions,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/30B01J20/26B01J20/34
CPCB01J20/261B01J20/34B01J2220/46
Inventor 王蕊欣谢美娜王晓刚门吉英高保娇曾俊成
Owner ZHONGBEI UNIV
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