Slightly-alkaline sodium acetate ringer's injection and preparation method

Abstract

The invention discloses a slightly-alkaline sodium acetate ringer's injection. Every 1,000 ml of the injection contains 5.7-6.3 g of sodium chloride, 0.27-0.33 g of potassium chloride, 0.18-0.22 g of calcium chloride and 3.61-3.99 g of sodium acetate. The preparation method of the injection comprises steps as follows: a preparation tank is filled with neutral gas for protection, then carbon-dioxide-free water for injection is added, all components are sequentially put into the water to be dissolved, and the volume is metered; the pH of the medicine liquid is adjusted to range from 7.3 to 7.5 and the medicine liquid is filtered; a packaging container is continuously filled with neutral gas for protection, potting is performed under the protection of the neutral gas, the semi-transparent packaging container is sleeved with a high-barrier bag, and vacuum pumping or neutral gas filling is performed for sealing; the injection is obtained after sterilization. The injection is stable in pH and can better play functions of regulating acid-base balance of organisms and supplementing electrolytes.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and relates to a weakly alkaline sodium acetate Ringer injection and a preparation method thereof. Background technique [0002] Extracellular fluid is a relatively stable internal environment required for the normal metabolism of cells in the body. In many disease processes, the balance of body fluids is often disrupted, resulting in abnormal water, electrolyte and acid-base balance and corresponding clinical manifestations, even life-threatening. Reasonable, safe, and simple water and electrolyte supplementation and acid-base imbalance correction are the most basic treatments. [0003] At present, physiological saline or compound sodium chloride injection is commonly used in clinic to supplement extracellular fluid and correct water and electrolyte balance, but its acid-base balance ability is relatively weak. Adding sodium lactate on the basis of compound sodium chloride injecti...

AI Technical Summary

Problems solved by technology

After the implementation of the above patents, it was found that when the pH of the injection was adjusted to be basically the same as that of the blood, affected by the hydrolysis of carbon dioxide during the preparation process, sterilization and storage, the pH would slowly drop, causing the pH to be unstable and unable to be consistent with the blood pH