Maca extract as well as preparation method and application thereof

A technology of maca extract and crude extract, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of many impurities, incomplete extraction, low absorption rate, etc., and achieve simple process, low price, and enhanced energy The effect of metabolic capacity

Inactive Publication Date: 2016-06-29
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the Maca market is very hot, and Maca products have several processing forms, such as micropowder (powder, tablet), freeze-drying, hydroalcoholic extract, etc.; but the existing technology is simple and rough, with low extraction efficiency and incomplete extraction. The nutritional content of the product is seriously lost, there are many impurities, the side effects are large, and the absorption rate of the human body is low, so it is difficult to exert the various functions of Maca

Method used

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  • Maca extract as well as preparation method and application thereof
  • Maca extract as well as preparation method and application thereof
  • Maca extract as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] 1. Preparation of maca extract

[0028] 200 grams of Maca samples are washed, drained and ground into powder; 70% methanol and concentrated hydrochloric acid are used to configure the extract in a ratio of 99:1, wherein hydrochloric acid can make the pigment in Maca appear red, which is beneficial to the next step Chromatography; add the above-mentioned extract in two times, add 500 ml for the first time, add 300 ml for the second time, extract with ultrasonic (300w, SB5200D) for about 1 hour after adding each time, and obtain the crude extract; The liquid was concentrated by rotary evaporation to no alcohol smell (about 200 ml) to obtain a concentrated crude extract; 200 grams of D101 macroporous resin (column volume about 200 ml) was weighed, and the concentrated crude extract obtained in step 3 was passed through the column, Adsorb for about 2 hours; elute the above macroporous resin in the order of one column volume of water, three column volumes of 20% ethanol, fou...

Embodiment 2

[0035] The preparation method of Maca extract comprises the following steps:

[0036] Step 1. Wash 200 grams of Maca, drain and make powder;

[0037] Step 2. Prepare the extract with 40% methanol and concentrated hydrochloric acid at a ratio of 98:2, add the extract twice, add 500 ml for the first time, add 500 ml for the second time, and extract about In 40 minutes, the crude extract was obtained;

[0038] Step 3. Concentrate the crude extract in step 2 by rotary evaporation until it has no alcohol smell (about 200 ml) to obtain a concentrated crude extract;

[0039] Step 4. Weigh 200 grams of D101 macroporous resin (column volume about 200 milliliters), pass the concentrated crude extract obtained in step 3 through the column, and absorb for about 2 hours;

[0040] Step 5, elute the macroporous resin in the order of one column volume of water, three column volumes of 20% ethanol, four column volumes of 50% ethanol, three column volumes of 75% ethanol, and one column volume...

Embodiment 3

[0043] The preparation method of Maca extract comprises the following steps:

[0044] Step 1. Wash 100 grams of Maca, drain and make powder;

[0045] Step 2, prepare the extract with 50% methanol and concentrated hydrochloric acid at a ratio of 99.5:0.5, add the extract twice, add 250 ml for the first time, add 250 ml for the second time, use ultrasonic extraction after each addition 50 minutes to obtain the crude extract;

[0046] Step 3. Concentrate the crude extract in step 2 by rotary evaporation until it has no alcohol smell (about 100 ml) to obtain a concentrated crude extract;

[0047] Step 4. Weigh 100 grams of D101 macroporous resin (column volume about 100 milliliters), pass the concentrated crude extract obtained in step 3 through the column, and absorb for about 2 hours;

[0048] Step 5, elute the macroporous resin in the order of one column volume of water, three column volumes of 20% ethanol, four column volumes of 50% ethanol, three column volumes of 75% ethanol...

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Abstract

The invention discloses a preparation method of a maca extract. The preparation method comprises the following steps of: cleaning and draining off maca and grinding the maca into powder; adding a methanol solution, water and concentrated hydrochloric acid and carrying out ultrasonic treatment to obtain a crude extract solution; concentrating the crude extract solution in the step (2) until no alcohol taste exits, thereby obtaining a concentrated crude extract; adsorbing the concentrated crude extract in the step (3) with macroporous resin; eluting the macroporous resin according to the order of one column volume of water, three column volumes of 20% ethanol, four column volumes of 50% ethanol, three column volumes of 75% ethanol and one column volume of 95% ethanol, and collecting an eluent; and carrying out ultralow-temperature freeze drying treatment on the eluent which is obtained by the third column volume of 20% ethanol and three column volumes of 50% ethanol, thereby obtaining the maca extract. The maca extract prepared by the method is obvious in cell ATP concentration increase effect and high in effective ingredient purity; the method is simple to operate, low in cost and suitable for massive production.

Description

technical field [0001] The invention relates to the field of extraction of effective plant components, in particular to a Maca extract, a preparation method and an application thereof. Background technique [0002] Maca is mainly produced in the Andes Mountains of South America and Lijiang, Yunnan, China. It is a cruciferous plant. The leaves are elliptical, and the rhizome is shaped like a small round radish. It is edible and is a kind of pure natural food with rich nutrients. Maca is rich in nutrients such as protein, minerals, sugars, amino acids, and functional ingredients such as alkaloids and glucosinolates. In recent years, more and more researchers have paid attention to the effect of Maca on improving human immunity, balancing human hormone secretion and promoting fertility, but little is known about its mechanism of action. At present, the Maca market is very hot, and Maca products have several processing forms, such as micropowder (powder, tablet), freeze-drying...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P37/04A61P15/08
CPCA61K36/31A61K2236/13A61K2236/15A61K2236/333A61K2236/55
Inventor 吕君蔚李浩丁显廷姜慧
Owner SHANGHAI JIAO TONG UNIV
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