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Medicine composition for treating diabetes containing rosiglitazone and preparation method of medicine composition

A technology for rosiglitazone and a composition is applied in the field of pharmaceutical compositions for the treatment of diabetes and the field of preparation thereof, which can solve problems such as restricting the use of rosiglitazone, achieve improved therapeutic effect, less side effects, and avoid gastrointestinal adverse reactions Effect

Inactive Publication Date: 2016-06-29
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common adverse reactions of rosiglitazone are gastrointestinal reactions, such as nausea, vomiting, diarrhea, abdominal pain, constipation, abdominal distension, indigestion, heartburn, etc. These adverse reactions are as high as 30%. usage of

Method used

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  • Medicine composition for treating diabetes containing rosiglitazone and preparation method of medicine composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0039] Rosiglitazone 4g, dill seedling 3000g, fragrant fruit tree 3000g, chao tree 3000g, bluegrass 3000g.

[0040] The preparation method of the pharmaceutical composition for treating diabetes:

[0041]a. Add water to decoct dill seedlings, fragrant fruit trees, chanterelles, and bluegrass for 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add water 5 times the volume of the medicine for the second time, and decoct Boil for 1 hour, combine the decoction and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing rosiglitazone wit...

Embodiment 2

[0047] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0048] 3g of rosiglitazone, 3500g of dill seedlings, 2500g of fragrant fruit tree, 3500g of chanting tree, 2500g of bluegrass.

[0049] The preparation method of the pharmaceutical composition for treating diabetes:

[0050] a. Add water to decoct dill seedlings, fragrant fruit trees, chanterelles, and bluegrass for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add water 6 times the volume of the medicine for the second time, and decoct Cook for 1.5 hours, combine the decoction liquid, and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[005...

Embodiment 3

[0056] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0057] Rosiglitazone 5g, dill seedlings 2500g, fragrant fruit tree 3500g, chao tree 2500g, bluegrass 3500g.

[0058] The preparation method of the pharmaceutical composition for treating diabetes:

[0059] a. Add water to decoct dill seedlings, fragrant fruit trees, chanterelles, and bluegrass for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, and decoct Boil for 0.5 hours, combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing rosiglitazone w...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine composition for treating the diabetes containing rosiglitazone and a preparation method of the medicine composition. The medicine composition is prepared from, by weight, 2-6 parts of rosiglitazone, 2000-4000 parts of Anethum graveolens L., 2000-4000 parts of emmenopterys henryi, 2000-4000 parts of litsea glutinosa and 2000-4000 parts of poa pratensis. The traditional Chinese medicines are combined with rosiglitazone, the common gastrointestinal tract adverse reaction of rosiglitazone can be avoided, and the diabetes treatment effect can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating diabetes containing rosiglitazone and a preparation method thereof. Background technique [0002] Diabetes is the second killer of modern diseases, and its harm to the human body is second only to cancer. In fact, diabetes itself is not terrible, what is terrible is the complications of diabetes, almost all the harm caused by diabetes comes from its complications. Among the diabetic patients in our country, there are as many as 12 million with high blood pressure, 5 million with stroke, 6 million with coronary heart disease, 450,000 with blindness, and 500,000 with uremia. [0003] Diabetes mellitus is a complex disease of multiple etiologies. It is a syndrome of glucose, protein and lipid metabolism disorders caused by the lack of insulin in the body or the increase of hormones that antagonize insulin, or the inability of i...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P3/10A61K31/4439
CPCA61K31/4439A61K9/1652A61K36/23A61K36/54A61K36/74A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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