A kind of Gansukang capsule and its preparation method

A technology of Gansukang and capsules, which is applied in the field of Gansukang capsules and its preparation, can solve the problems of poor dissolution effect and unresolved taste of Gansukang, and achieve the goal of prolonging residence time, reducing moisture absorption and improving stability Effect

Active Publication Date: 2019-04-16
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gansukang obtained by the preparation method does not solve the problems of bad mouthfeel and poor dissolution effect

Method used

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  • A kind of Gansukang capsule and its preparation method
  • A kind of Gansukang capsule and its preparation method
  • A kind of Gansukang capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] Preparation:

[0030] (1) After dissolving oleanolic acid with ethanol, add acrylic resin No. II and stir evenly to obtain a core material.

[0031] (2) Weigh hypromellose, slowly add distilled water under constant stirring to make a 3% water dispersion by mass, and put it in a spray tank for subsequent use;

[0032] (3) Put the core material obtained in step (1) into a fluidized bed, adjust the air inlet temperature to 65°C, the air outlet temperature to 55°C, and the feeding rate to 10ml / min, spray, spray, and pass through 30 meshes after forming microcapsules Sieve, then add polysaccharides from Yunzhi polysaccharide, starch, microcrystalline cellulose, and magnesium stearate, spray and mix evenly, dry at 60°C, sieve with 20-30 meshes for granulation, and obtain Gansukang granules.

[0033] (4) Subpackage: pack the capsule granules prepared in step (2) into capsules to obtain the Gansukang capsules.

Embodiment 2

[0035]

[0036] Preparation:

[0037] (1) After dissolving oleanolic acid with ethanol, add acrylic resin No. II and stir evenly to obtain a core material.

[0038] (2) Weigh hypromellose, slowly add distilled water under constant stirring to make a 3% water dispersion by mass, and put it in a spray tank for subsequent use;

[0039] (3) Put the core material obtained in step (1) into a fluidized bed, adjust the air inlet temperature to 70°C, the air outlet temperature to 60°C, and the feeding rate to 10ml / min, spray, spray, and pass through 30 meshes after forming microcapsules Sieve, then add polysaccharides from Yunzhi polysaccharide, starch, microcrystalline cellulose, and magnesium stearate, spray and mix evenly, dry at 50°C, sieve with 20-30 meshes for granulation, and obtain Gansukang granules.

[0040] (4) Subpackage: pack the capsule granules prepared in step (2) into capsules to obtain the Gansukang capsules.

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Abstract

The invention discloses Gansukang capsules and a preparation method thereof. The Gansukang capsules are prepared from oleanolic acid, coriolus versicolor polysaccharide, starch, microcrystalline cellulose, magnesium stearate, hydroxypropyl methylcellulose, acrylic resin II and an amount of ethanol. The mouthfeel and dissolution rate of the Gansukang capsules are effectively improved, and in addition, the preparation method adopts a technique that the oleanolic acid is coated with the adjuvant, so that the pharmaceutical stability is improved and the hygroscopic effect in the storage process is reduced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a Gansukang capsule and a preparation method thereof. Background technique [0002] Hepatitis B is an enemy that endangers human health, and it is also one of the most harmful diseases in my country's infectious diseases. There are currently nearly 30 million chronic hepatitis B patients in China, and only 19% of them are receiving formal antiviral treatment. In my country, nearly 280,000 people die from liver cirrhosis, liver cancer and other liver-related diseases every year, and the number of new and dead liver cancer patients accounts for more than half of the world, most of which are caused by viral hepatitis. [0003] Gansukang Capsule is a compound preparation, which contains oleanolic acid and versicolor polysaccharide raw materials. It has the functions of reducing enzymes and turbidity, adjusting the immune function of the body, improving metaboli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K31/56A61K9/48A61K47/38A61P1/16A61P31/20
CPCA61K9/1652A61K31/56A61K31/715A61K2300/00
Inventor 刘景萍刘全国陈克领林文君李党
Owner HAINAN HULUWA PHARMA GRP CO LTD
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