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Medicinal composition for treating severe acute pancreatitis and application thereof

A technology for acute pancreatitis and a composition, applied in the field of medicine, can solve the problems of severe acute pancreatitis without gabexate mesylate, no reports of gabexate mesylate and theanine bromoyl and the like

Inactive Publication Date: 2016-07-20
张雪燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no report on the combined use of gabexate mesylate and bromoyl theanine at home and abroad, and there is no literature report on the treatment of severe acute pancreatitis with gabexate mesilate combined with bromoyl theanine

Method used

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  • Medicinal composition for treating severe acute pancreatitis and application thereof
  • Medicinal composition for treating severe acute pancreatitis and application thereof
  • Medicinal composition for treating severe acute pancreatitis and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Example 1 Effect of Gabexate Mesylate / Theanine Bromide on Severe Acute Pancreatitis Rat Model

[0021] 50 clean grade male SD rats, body weight 190-210g. The rats were randomly divided into the following five groups, with 10 rats in each group: ①Sham operation group: laparotomy, exposing the pancreas, but no sodium taurocholate injection; ②Model group: retrograde injection of 5% sodium taurocholate to induce Severe acute pancreatitis model; ③ Gabexate mesylate group (GM group): Gabexate mesylate was administered intravenously 1 hour after modeling; ④ Theanine bromoaramide group (TBrC group): 1 hour after model making , intravenous administration of theanine bromide; ⑤ Gabexate mesylate + theanine bromide group (GM+TBrC group): 1 hour after modeling, intravenous administration of gabexate mesylate and theanine Bromide.

[0022] Severe acute pancreatitis model production method: rats were fasted for 12 hours before operation, free to drink water, and then anesthetized b...

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PUM

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Abstract

The invention discloses a medicinal composition for treating severe acute pancreatitis and application of the medicinal composition. The active ingredients of the medicinal composition comprise gabexate mesylate and theanine bromine amide of which the weight dosage ratio is (1: 10) to 50 preferably. Animal experimental study finds that the combined use of gabexate mesylate and theanine bromine amide can obviously reduce the levels of proinflammatory factors, namely TNF (Tumor Necrosis Factor)-alpha and IL (Interleukin)-6 to reduce rat pancreatic damages and obtain an obvious effect on synergistic treatment of the severe acute pancreatitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating severe acute pancreatitis and its application. Background technique [0002] Acute pancreatitis (AP) is a common emergency of the digestive system, among which severe acute pancreatitis (SAP) is dangerous and has a high mortality rate. The pathogenesis of SAP is a complex process involving multiple factors and multiple steps (TALUKDARR, SWAROOPVEGES. Early management of severe pancreatitis [J]. CurrGastroenterolRep, 2011, 13(2): 123-130.), with the deepening of research on its pathogenesis , Researchers have put forward many theories, such as "cytokine theory", "leukocyte overactivation theory" and so on. SAP is first manifested as an inflammatory response, and as the disease progresses, the inflammatory response spreads from the pancreas to the whole body. "Cytokine theory" (KYL魧NP魧魧魧ML, REPOH, PUOLAKKAINENPA.Inflammationa...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61K31/235A61P1/18
CPCA61K31/37A61K31/235A61K2300/00
Inventor 张雪燕
Owner 张雪燕