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Preparation method of modified chitosan-based hemostatic sponge

A technology of hemostatic sponge and chitosan, applied in the field of medical materials, can solve the problems of insignificant hemostatic effect and poor toughness, and achieve the effect of preventing wound infection and promoting healing

Inactive Publication Date: 2016-07-20
NINGBO JIANGDONG LINQING ENVIRONMENTAL PROTECTION & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem mainly solved by the present invention: In view of the problems of poor toughness and insignificant hemostatic effect of the current pure chitosan hemostatic material, the present invention first acylates chitosan, combines with leucine, and then adds antibacterial substances Mix it with it to make the combined chitosan hydrophobic, and then mix it with Burnet extract for grafting reaction to enhance its hemostatic healing ability, thus preparing a modified chitosan-based hemostatic sponge

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Weigh 700g of chitosan and put it into a 2L beaker, add 12% acetic acid solution to it, stir at a speed of 180r / min until the chitosan is completely dissolved, stop adding the acetic acid solution, and then weigh 110g of leucine Put the acid into the beaker, stir evenly, then move the beaker to an ultrasonic cleaner, and vibrate at 22KHz for 30min; Put succinic anhydride into a beaker, set the temperature at 70°C, stir and heat for 6 hours, then weigh 50g of sulfadimethoxine and 20g of 1-ethyl-(3-dimethylaminopropyl)carbonyldimethoxy Put the amine hydrochloride into a beaker and stir evenly; after the above stirring is even, move the beaker to a water bath, and perform a modification reaction at 60°C for 20 hours. The mixture in the beaker is filtered through a ceramic membrane, and the filtrate is collected and put into a dialysis bag. After dialysis with deionized water for 27 hours, a cloudy solution is obtained. The obtained cloudy solution is put into a spray dryer...

example 2

[0020] Take by weighing 800g chitosan and put it into a 2L beaker, add a mass fraction of 12% acetic acid solution therein, stir with a rotating speed of 180r / min until the chitosan is completely dissolved, stop adding the acetic acid solution, and then weigh 130g leucine Put the acid into the beaker, stir evenly, then move the beaker to an ultrasonic cleaner, and vibrate at 25KHz for 50min; Put succinic anhydride into a beaker, set the temperature at 80°C, stir and heat for 9 hours, then weigh 70g of sulfadimethoxine and 30g of 1-ethyl-(3-dimethylaminopropyl)carbonyl dimethoxy Put the amine hydrochloride into a beaker and stir evenly; after the above stirring is even, move the beaker to a water bath, and conduct a modification reaction at 70°C for 22 hours. The mixture in the beaker is filtered through a ceramic membrane, and the filtrate is collected and put into a dialysis bag. After dialysis with deionized water for 32 hours, a cloudy solution is obtained. The obtained clo...

example 3

[0023] Weigh 750g of chitosan and put it into a 2L beaker, add 12% acetic acid solution to it, stir at a speed of 180r / min until the chitosan is completely dissolved, stop adding the acetic acid solution, and then weigh 120g of leucine Put the acid into a beaker, stir evenly, then move the beaker to an ultrasonic cleaner, and vibrate at 24KHz for 40min; Put succinic anhydride into a beaker, set the temperature at 75°C, stir and heat for 8 hours, then weigh 60g of sulfadimethoxine and 25g of 1-ethyl-(3-dimethylaminopropyl)carbonyl dimethoxy Put the amine hydrochloride into a beaker and stir evenly; after the above stirring is even, move the beaker to a water bath, and perform a modification reaction at 60-70°C for 21 hours, stop heating after the reaction is completed, and cool naturally to room temperature. Then filter the mixture in the beaker through a ceramic membrane, collect the filtrate and put it into a dialysis bag, use deionized water to dialyze for 30 hours to obtain...

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Abstract

The invention discloses a preparation method of modified chitosan-based hemostatic sponge, belongs to the field of medical materials, and aims to solve the problems that the conventional pure chitosan hemostatic material is low in toughness and poor in hemostatic effect. According to the preparation method, chitosan is acidylated and then is combined with leucine, and an antibacterial substance is added for mixing reaction, so that the combined chitosan is hydrophobic, and then is mixed with a sanguisorba officinalis extract for grafting reaction, enhancing the hemostatic curing capacity of the chitosan; therefore, the modified chitosan-based hemostatic sponge is prepared.

Description

technical field [0001] The invention discloses a preparation method of a modified chitosan-based hemostatic sponge, which belongs to the field of medical materials. Background technique [0002] Absorbable hemostatic materials are currently a hot spot in the field of surgery. Bleeding and oozing are often encountered in surgery, trauma surgery or war wounds. Compared with traditional methods such as electrocautery, suture, ligation and traditional gauze , the absorbable hemostatic material has the characteristics of little tissue damage, easy operation, rapid hemostasis, etc., but the biocompatibility of the absorbable hemostatic material in the prior art is still not ideal. [0003] Chitosan is a natural polycationic polysaccharide prepared by deacetylation of chitin, and carboxymethyl chitosan is a water-soluble derivative obtained after chemical modification of chitin. Both chitosan and carboxymethyl chitosan have multiple functions such as coagulation, antibacterial, pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00C08B37/08
CPCA61L24/08A61L24/0015A61L24/0036A61L2300/216A61L2300/30A61L2300/404A61L2300/418A61L2400/04C08B37/003
Inventor 林倩倩宋国
Owner NINGBO JIANGDONG LINQING ENVIRONMENTAL PROTECTION & TECH CO LTD
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