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A composite nanomaterial with long afterglow of upconversion excited by near-infrared light and its preparation

A composite nanomaterial and nanomaterial technology are applied in the field of near-infrared light-excited upconversion long afterglow composite nanomaterials and their preparation, which can solve the problems of shallow penetration depth, low luminous efficiency, and reduced in vivo imaging efficiency, and achieve detection Simple equipment and high signal-to-noise ratio

Active Publication Date: 2018-05-01
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the excitation light of long-lasting nanoparticles emitted by the near-infrared ranges from 230 to 600nm, which is in the ultraviolet and visible light regions, the more commonly used excitation light is ultraviolet light and LEDs. These light sources have shallow penetration depth and low luminous efficiency, thereby reducing the In vivo imaging efficiency

Method used

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  • A composite nanomaterial with long afterglow of upconversion excited by near-infrared light and its preparation
  • A composite nanomaterial with long afterglow of upconversion excited by near-infrared light and its preparation
  • A composite nanomaterial with long afterglow of upconversion excited by near-infrared light and its preparation

Examples

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example 1

[0047] Example 1: Preparation of composite nanomaterials with long afterglow upconversion excited by near-infrared light

[0048] Preparation of Long Persistence ZnO Nanomaterial Zn 1.1 Ga 1.8 Ge 0.1 o 4 : Cr 3+ 0.005 Nanoparticles, the specific method is as follows: 16.134mmol Ga 2 o 3 10mL of 35% concentrated nitric acid was reacted overnight at 150°C under hydrothermal conditions to obtain the chloride salt products of Ga and Ge; 0.004mmol of chromium nitrate and 8.97mmol of zinc nitrate were dissolved in 10mL of water, and 0.894mmol of GeO was dissolved in as little as possible ammonia water, and the solution was transferred to the above-mentioned gallium nitrate solution and vigorously stirred, and the resulting solution was washed with 30% NH 3 ·H 2 O to adjust the pH to 7.5 and stir at room temperature for 3 h; after stirring, transfer the solution to a 25 mL stainless steel high-temperature steam sterilizer with an insulated edge and heat at 120 °C for 24 h; t...

example 2

[0051] Example 2: Preparation of composite nanomaterials with long afterglow upconversion excited by near-infrared light

[0052] Preparation of Long Persistence Nanomaterial Zn 1.1 Ga 1.8 Ge 0.1 o 4 : Cr 3+ 0.005 Nanoparticles, the specific method is as follows:

[0053] 16.134 mmol Ga 2 o 3 , 10mL of 35% concentrated nitric acid was reacted overnight at 150°C under hydrothermal conditions to obtain the chloride salt products of Ga and Ge; 0.004mmol of chromium nitrate and 8.97mmol of zinc nitrate were dissolved in 10mL of water, and 0.894mmol of GeO was dissolved in as much A small amount of ammonia water, and the solution was transferred to the above-mentioned gallium nitrate solution and stirred vigorously, and the resulting solution was washed with 30% NH 3 ·H 2 O to adjust the pH to 7.5 and stir at room temperature for 3 h; after stirring, transfer the solution to a 25 mL stainless steel high-temperature steam sterilizer with an insulated edge and heat at 120 °C...

example 3

[0056] Example 3: Preparation of composite nanomaterials with long afterglow upconversion excited by near-infrared light

[0057] Preparation of Long Persistence Nanomaterial Zn 1.1 Ga 1.8 Ge 0.1 o 4 : Cr 3+ 0.005 Nanoparticles, the specific method is as follows:

[0058] 16.134 mmol Ga 2 o 3 , 10mL of 35% concentrated nitric acid was reacted overnight at 150°C under hydrothermal conditions to obtain the chloride salt products of Ga and Ge; 0.004mmol of chromium nitrate and 8.97mmol of zinc nitrate were dissolved in 10mL of water, and 0.894mmol of GeO was dissolved in as much A small amount of ammonia water, and the solution was transferred to the above-mentioned gallium nitrate solution and stirred vigorously, and the resulting solution was washed with 30% NH 3 ·H 2 O to adjust the pH to 7.5 and stir at room temperature for 3 h; after stirring, transfer the solution to a 25 mL stainless steel high-temperature steam sterilizer with an insulated edge and heat at 120 °C...

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Abstract

The invention belongs to the field of preparation and application of nano materials, and discloses a composite nano material capable of exciting upconversion steady persistence through near-infrared light, and preparation method and application of the composite nano material. By utilizing the composite nano material disclosed by the invention, the situation that nanoparticles are excited by near-infrared wavelength light to generate steady persistence luminescence is realized. The composite nano material is of a special composition structure which is obtained through combination of an upconversion nano material and a steady persistence nano material. According to the composite nano material disclosed by the invention, the situation that visual light emitted the upconverision nano material after near-infrared light is absorbed by the upconversion nano material is matched with absorbed light of the steady persistence nano material, i.e., the visual light emitted by the upconversion nano material is absorbed by the steady persistence nano material, so that light emitting of the steady persistence nano material is realized, the generation of steady persistence luminescence under the exciting of the near-infrared light is realized, the problems of a traditional steady persistence nano probe that the penetrating power of short-wavelength laser is weak, materials in a living organism cannot be excited, and the like are overcome, and deep optical imaging with continuous detection, high SNR (Signal to Noise Ratio) and a simple detecting device and without background exciting light, tissue autofluorescence, and a light filter is realized.

Description

technical field [0001] The invention belongs to the field of preparation and application of nanomaterials, and particularly relates to a composite nanomaterial with long afterglow up-conversion excited by near-infrared light and its preparation method and application. The composite nano-material with long afterglow up-conversion excited by near-infrared light of the present invention can realize Near-infrared wavelength light excites the nanoparticles to produce long-lasting luminescence. Background technique [0002] In recent years, fluorescence optical imaging has shown many unique advantages in biomedicine, such as high sensitivity, no radiation hazard, cost-effective, portable, and suitable for imaging-guided surgery. With the rapid development of nanotechnology, the combination of fluorescence optical imaging and nanotechnology provides new prospects for the diagnosis and treatment of diseases. The long afterglow nanoparticles (Persistent Luminescent Nanoparticles, PL...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/86C09K11/02A61K49/00
CPCA61K49/0004A61K49/005A61K49/0093C09K11/02C09K11/7793
Inventor 詹求强丁诗雨蒲锐
Owner SOUTH CHINA NORMAL UNIVERSITY
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