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Method for preparing traditional Chinese medicine preparation for clearing away heat and toxic materials and resisting bacteria and diminishing inflammation

A technology of antibacterial and anti-inflammatory and traditional Chinese medicine preparations, which is applied in the direction of anti-inflammatory agents, antipyretics, and pharmaceutical formulas. It can solve the problems of resource waste of Chinese medicinal materials, increase production costs, and affect product quality, so as to save energy and cost, and avoid degradation. , improve the efficacy of the drug

Inactive Publication Date: 2016-08-03
JIANGXI KINGSTONE UNITE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the current preparation of this product is mainly through traditional extraction techniques such as direct heating and decoction followed by filtration and alcohol precipitation, the preparation process is relatively rough, which will easily lead to low extraction rate and serious waste of Chinese medicinal resources, and the heat-sensitive functional components of medicinal materials It is easy to degrade when heated, which increases the production cost and seriously affects the quality of the product and the efficacy of oral absorption

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Prescription composition: honeysuckle 187.5kg, skullcap 187.5kg, forsythia 375kg, starch 15kg, made into 100000 capsules (0.4g / capsule).

[0023] The following steps are adopted to prepare: 187.5kg of honeysuckle, 187.5kg of baicalin and 375kg of forsythia are respectively pulverized into 15 micron fine powders by ultrafine pulverization technology; Once 0.5h (ultrasonic power is 60kw, temperature is room temperature), filter after extraction, and combine the filtrate; concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.05-1.10 at 60°C, and use 2mol / L Adjust the pH value to 1.5 with hydrochloric acid solution, keep warm for 1 hour, let it stand for 24 hours, filter, wash the precipitate with water until the pH value is 5.0, and then wash with 70% ethanol until the pH value is 7.0, dry under reduced pressure and low temperature to obtain the extract of Scutellaria baicalensis Then add the crushed honeysuckle and forsythia medicin...

Embodiment 2

[0062] Prescription composition: 750kg of honeysuckle, 750kg of skullcap, 1500kg of forsythia, 75kg of starch, made into 430000 capsules (0.4g / capsule).

[0063] The following steps are used to prepare: 750kg honeysuckle, 750kg Scutellaria baicalensis and 1500kg Forsythia forsythia are respectively pulverized into 30 micron fine powders by ultra-fine pulverization technology, and set aside; the pulverized Scutellaria baicalensis medicinal powder is added to water 8 times the weight of the medicinal materials and ultrasonically extracted 3 times, each time 1.5 h (ultrasonic power is 80kw, temperature is room temperature), after extraction, filter and combine the filtrate; concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.05-1.10 at 60°C, and use 2mol / L hydrochloric acid solution at 60°C Adjust the pH value to 1.5, keep it warm for 1 hour, let stand for 24 hours, filter, wash the precipitate with water until the pH value is 5.0, then wa...

Embodiment 3

[0065] Prescription composition: honeysuckle 375kg, skullcap 375kg, forsythia 750kg, lactose 40kg, made into 215000 capsules (0.4g / capsule).

[0066] The following steps are used to prepare: 375kg honeysuckle, 375kg Scutellaria baicalensis and 750kg Forsythia forsythia are respectively crushed into 20 micron fine powders by ultrafine pulverization technology; h (ultrasonic power is 65kw, temperature is room temperature), after extraction, filter and combine the filtrate; concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.05-1.10 at 60°C, and use 2mol / L hydrochloric acid solution at 60°C Adjust the pH value to 1.5, keep it warm for 1 hour, let stand for 24 hours, filter, wash the precipitate with water until the pH value is 5.0, then wash with 70% ethanol until the pH value is 7.0, dry under reduced pressure and low temperature, and obtain the Scutellaria baicalensis extract. Standby; then add the crushed honeysuckle and forsythia medi...

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Abstract

The invention relates to a method for preparing a traditional Chinese medicine preparation for clearing away heat and toxic materials and resisting bacteria and diminishing inflammation, and relates to the technical field of extraction and preparation of a traditional Chinese medicine preparation .The shuanghuanglian capsule is prepared by mixing flos lonicerae, radix scutellariae and fructus forsythia after superfine grinding, ultrasonic extracting, an ethanol subsiding method, membrane filtration and other modern extracting technologies .The method has the advantages that superfine grinding and ultrasonic extracting are combined, the extraction time is short, the extraction rate is high, medicinal materials can be fully utilized, degradation of heat-sensitive ingredients is avoided, medicinal material resources are saved, and the production cost is reduced.

Description

technical field [0001] The invention relates to an extraction and preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of a traditional Chinese medicine preparation for clearing heat, detoxifying, antibacterial and anti-inflammatory. Background technique [0002] Shuanghuanglian Capsule is composed of honeysuckle, scutellaria baicalensis and forsythia. It is used for the treatment of colds caused by exogenous wind-heat, such as fever, cough, and sore throat. However, since the current preparation of this product is mainly through traditional extraction techniques such as direct heating and decoction followed by filtration and alcohol precipitation, the preparation process is relatively rough, which easily leads to low extraction rate and serious waste of Chinese medicinal resources, and the heat-sensitive functional components of medicinal materials It is easy to degrade when heated, increases the production cost, and serio...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/48A61P11/00A61P29/00A61P11/14A61P11/04
CPCA61K9/1605A61K36/355A61K36/539A61K36/634A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 谢棋李旭刘长元刘路加杜平荣邹贵阳
Owner JIANGXI KINGSTONE UNITE PHARMA CO LTD