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Medicinal composition for preventing and treating visceral white spot disease of half-smooth tongue sole

A technology for visceral white spot disease and semi-smooth tongue sole, which is applied in the directions of drug combination, anti-infective drugs, pharmaceutical formulations, etc., can solve problems such as economic loss, threaten the semi-smooth tongue sole breeding industry, etc., and achieve the effects of low cost, easy mastery and simple method.

Active Publication Date: 2018-08-10
HEBEI AGRICULTURAL UNIV.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In aquaculture factories where visceral white spot disease breaks out, the daily mortality rate of juvenile fish and adult fish can reach more than 0.6%, and the cumulative mortality rate can be as high as 60%-70%, which has caused great economic losses to the breeding and seriously threatened to the whole farming industry of tongue sole
At present, there is no report on the treatment of visceral white spot disease in half-smooth tongue sole at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Therapeutic test on visceral white spot disease of juvenile tongue sole half-smooth tongue sole

[0024] In mid-June 2014, 100,000 juvenile tongue soles bred by Qinhuangdao Haixin Aquaculture Technology Development Co., Ltd. had visceral white spot disease and mass mortality to varying degrees. The average weight of juvenile half-smooth tongue sole in the fish pond is below 50g / tail, and there are 3-4 red ulcerated spots on the side without eyes of the fish body, mainly concentrated near the gill cover, and some sick fish have a ulcerated spot on the tail; the sick fish eat Reduced, there is white feces at the bottom of some breeding ponds; dissecting sick fish, all individuals show the main symptoms of visceral white spot disease, that is, kidneys and spleens are covered with white spots (both on the surface and inside), and the color of the kidneys becomes pale.

[0025] The oral medicine bait formulated with the pharmaceutical composition of the present inv...

Embodiment 2

[0027] Example 2 Therapeutic test on visceral white spot disease of juvenile tongue sole half-smooth tongue sole

[0028] From the end of August to the beginning of September 2015, 200,000 juvenile half-smooth tongue sole bred in the Huanghua Tilapia Breeding Farm suffered from visceral white spot disease and mass mortality to varying degrees. The average weight of the juvenile tongue sole in the fish pond is about 120g / tail, and the body color of the fish becomes darker, the vitality decreases, the grouping is poor, and the food intake decreases. White spots, the diameter of white spots is 0.3-0.6mm, and a few individuals also have white spots in the liver, but the density is smaller.

[0029] The oral medicinal bait prepared by the pharmaceutical composition of the present invention is used for feeding, and at the same time, the hydrogen peroxide dipping method is used to treat the visceral white spot disease of semi-smooth tongue sole.

[0030] The specific method is as fo...

Embodiment 3

[0031] Example 3 Therapeutic test on visceral white spot disease of half-smooth tongue sole adult fish

[0032]From the end of September to the beginning of October 2015, Tangshan Haidu Aquatic Food Co., Ltd. raised 120,000 commercial fish of semi-smooth tongue sole to varying degrees with visceral white spot disease and mass mortality. The average weight of the commercial fish of semi-smooth tongue sole in the fish pond is about 600g / tail, and the body color becomes darker, the vigor decreases, the gregariousness is poor, and the food intake decreases. On the gill cover, the diameter of the rotten spot is 2.5-6.8mm; there are white feces at the bottom of some culture ponds; dissecting the sick and dead fish, the kidney and spleen in the viscera are covered with white spots, and a few sick fish have a small amount of white spots in the liver. 0.6-2.1mm, the color of the kidney is obviously lighter and brown, the color of the spleen is slightly lighter, and the color of the hea...

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating visceral white-spot disease of cynoglossus semilaevis. The pharmaceutical composition comprises the following components in percentage by mass: 30-70% of ceftriaxone sodium and 70-30% of enrofloxacin. The pharmaceutical composition also comprises hydrogen peroxide. In the pharmaceutical composition, medicine bait for oral administration as well as a hydrogen peroxide medicated bath of proper concentration are adopted. The pharmaceutical composition is a composite and comprehensive pharmaceutical composition which can be effectively used for preventing and treating the visceral white-spot disease of cynoglossus semilaevis in the juvenile stage and adult stage and can cure the visceral white-spot disease of cynoglossus semilaevis in different regions. The pharmaceutical composition has the advantages of easiness in use, small dosage, low cost and high cure rate of 95% or over.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for preventing and treating visceral white spot disease of half-smooth tongue sole. Background technique [0002] Semi-smooth tongue sole is a local species in the coastal area of ​​my country. Since the successful artificial breeding, the aquaculture industry has developed rapidly due to its excellent breeding traits. It has now become an important aquaculture species in the northern coastal areas of my country. Very good economic and social benefits. However, with the expansion of the breeding range and the increase of the breeding density, as well as the confusion of the breeding management and the lack of effective monitoring, the disease problem of the tongue sole is becoming more and more serious, which has become a key factor restricting the healthy development of the tongue sole industry. The white spot disease of the tongue sole is the visceral ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K31/496A61P33/02
CPCA61K31/496A61K31/546A61K33/40A61K2300/00
Inventor 宫春光殷蕊孙桂清
Owner HEBEI AGRICULTURAL UNIV.