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DMAPS-AA-AAS (N,N-dimethyl(methylacryloyloxyethyl)aminopropanesulfonic acid inner salt-acrylic acid-sodium acrylate) copolymer, and preparation method and application thereof

A DMAPS-AA-AAS, 1. DMAPS-AA-AAS technology, applied in the field of polymer preparation and application, can solve the problems of limited effect and single effect, and achieve good biocompatibility and bionicity, The effect of simple operation and convenient mass production

Active Publication Date: 2016-08-24
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These natural compounds have indeed played a certain effect on the regulation of macrophages, but the effect is relatively single and the effect is limited

Method used

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  • DMAPS-AA-AAS (N,N-dimethyl(methylacryloyloxyethyl)aminopropanesulfonic acid inner salt-acrylic acid-sodium acrylate) copolymer, and preparation method and application thereof
  • DMAPS-AA-AAS (N,N-dimethyl(methylacryloyloxyethyl)aminopropanesulfonic acid inner salt-acrylic acid-sodium acrylate) copolymer, and preparation method and application thereof
  • DMAPS-AA-AAS (N,N-dimethyl(methylacryloyloxyethyl)aminopropanesulfonic acid inner salt-acrylic acid-sodium acrylate) copolymer, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Add 20g monomer DMAPS and 80g monomer AA into the reaction vessel, add a certain amount of deionized water and stir evenly; make the total amount of monomer DMAPS and AA account for 20% by mass of the total amount of the aqueous solution; Ammonium sulfate is made into a 1wt% aqueous solution, and when the temperature of the water bath rises to 65°C, it is added dropwise into the reaction vessel with a dropping funnel; the reaction is kept for 5 hours, and after the reaction is completed, the material can be discharged after cooling to room temperature, and DMAPS is obtained. - AA copolymers. Then add the sodium hydroxide solution of 10wt% concentration in the DMAPS-AA copolymer of 10% concentration, adjust pH value 3.0~3.5, stir 3 hours, make part of acrylic acid in the copolymer convert into sodium acrylate (AAS), make sodium acrylate The content accounts for 30% of the total monomer content, and a DMAPS-AA-AAS copolymer with an AAS content of 30% is prepared.

Embodiment 2

[0032] Add 20g monomer DMAPS and 80g monomer AA into the reaction container, add a certain amount of deionized water and stir evenly; make the total amount of monomer DMAPS and AA account for 20% by mass of the total aqueous solution; under nitrogen protection, persulfuric acid Ammonium is made into a 1wt% aqueous solution, and when the temperature of the water bath rises to 65°C, it is added dropwise into the reaction container with a dropping funnel, and the reaction is kept for 5 hours. AA copolymer. Then add the sodium hydroxide solution of 10wt% concentration in the DMAPS-AA copolymer of 10% concentration, adjust pH value 5.5~6.0, stir 3 hours, make part of acrylic acid in the copolymer convert into sodium acrylate (AAS), make sodium acrylate The content accounts for 60% of the total monomer content, and a DMAPS-AA-AAS copolymer with an AAS content of 60% is prepared.

Embodiment 3

[0034] Add 20g monomer DMAPS and 80g monomer AA into the reaction container, add a certain amount of deionized water and stir evenly; make the total amount of monomer DMAPS and AA account for 20% by mass of the total aqueous solution; under nitrogen protection, the initiator Ammonium persulfate is made into a 1wt% aqueous solution, and when the temperature of the water bath rises to 65°C, it is added dropwise to the reaction container with a dropping funnel; it is kept for 5 hours, and after the reaction is completed, it can be discharged after cooling to room temperature. DMAPS-AA copolymer. Then add the sodium hydroxide solution of 10wt% concentration in the DMAPS-AA copolymer of 10% concentration, adjust pH value 7.0~7.5, stir 3 hours, make all acrylic acid in the copolymer convert into sodium acrylate (AAS), make sodium acrylate The content accounts for 80% of the total monomer content, and the DMAPS-AA-AAS copolymer with 80% AAS content is prepared.

[0035] The biologic...

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Abstract

The invention is applicable to the field of preparation and application of high-molecular polymers, and provides a preparation method of a DMAPS-AA-AAS (N,N-dimethyl(methylacryloyloxyethyl)aminopropanesulfonic acid inner salt-acrylic acid-sodium acrylate) copolymer. The preparation method comprises the following steps: adding a monomer DMAPS and a monomer AA into deionized water to obtain a mixed solution; preparing an initiator solution, adding the initiator into the mixed solution, heating the obtained solution to 65-85 DEG C, reacting for 4-6 hours, and cooling to room temperature to obtain a DMAPS-AA copolymer; and adding a 5-15 wt% sodium hydroxide solution into the DMAPS-AA copolymer to regulate the pH value, and stirring for 2-5 hours, thereby preparing the DMAPS-AA-AAS copolymer. The invention also provides a DMAPS-AA-AAS copolymer prepared by the preparation method. The invention also provides application of the DMAPS-AA-AAS copolymer. The DMAPS-AA-AAS copolymer provided by the invention opens up a new way for regulation of immunocompetence of macrophages. The preparation method provided by the invention is simple to operate and convenient for mass production.

Description

technical field [0001] The invention belongs to the field of polymer preparation and application, and in particular relates to DMAPS-AA-AAS copolymer and its preparation method and application. Background technique [0002] Immune cells play an important role in disease prevention, tumor and cancer treatment, and macrophages in particular play an important role in the immune response of various functions, including from wound healing to fighting against microorganisms. Currently, antibodies or active immune biomaterials are widely used to promote macrophages to phagocytose tumor cells or bacteria. In order to weaken non-specific phagocytosis, nanoparticles or other implants are usually surface-treated with some passive immune biomaterials, such as phosphorylcholine zwitterionic copolymers, or coated with polysaccharides. In addition, studies have also reported that the phagocytosis of human neutrophils can be activated by β-1,6-glucan. Therefore, we believe that phagocytos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/06C08F220/38C08F8/44A61P29/00A61P35/00A61P17/02A61P37/06A61P37/04
CPCC08F8/44C08F220/06C08F220/387
Inventor 陈少军卓海涛任换换梅占奎
Owner SHENZHEN UNIV
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