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Double-component high-strength hydrogel and preparation method thereof

A hydrogel, two-component technology, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, aerosol delivery, etc., can solve the problems of insufficient strength and slow release effect, and achieve simple operation Effect

Active Publication Date: 2016-09-07
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the strength of the hydrogel is not enough, it will be broken and thinned in the living body, and the drug embedded in the hydrogel will be released directly, which cannot achieve the effect of sustained release.

Method used

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  • Double-component high-strength hydrogel and preparation method thereof
  • Double-component high-strength hydrogel and preparation method thereof
  • Double-component high-strength hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] An aqueous solution of polymer 1 (50 repeating units, 1 mL, 50 mg / mL) and an aqueous solution of N-isopropylamine acrylamide-o-hydroxymethylbenzene borate half ester random copolymer (1 mL, 50 mg / mL, pH=7.5) Quickly stir and mix evenly, and stand still for 30 minutes to obtain a hydrogel.

[0036] figure 1 It is an effect comparison chart of the experimental results of Example 1 of the present invention and Comparative Example 1. It can be seen from the figure that under the same component dosage and concentration conditions, Example 1 obtained a hydrogel structure, while the two tests of Comparative Example None of the hydrogel structures were obtained. This is because the dynamic covalent bond formed between the sugar polymer selected in Example 1 and the half-ester of o-hydroxymethylphenylboronic acid is stronger, and the stronger bonding strength can promote the mixture to form a hydrogel structure. In Comparative Example 1, the dynamic covalent bond formed betwee...

Embodiment 2

[0038] An aqueous solution of polymer 2 (100 repeating units, 1 mL, 100 mg / mL) and an aqueous solution of N-isopropylamine acrylamide-o-hydroxymethylbenzene borate half ester random copolymer (1 mL, 100 mg / mL, pH=7.5) Quickly stir and mix evenly, and stand still for 30 minutes to obtain a hydrogel.

[0039] figure 2 It is the appearance figure of the hydrogel prepared in embodiment 2, image 3 The scanning electron microscope image of the hydrogel prepared in Example 2 of the present invention shows that the gel can form a regular three-dimensional network structure.

[0040] Figure 4 For the storage modulus curves of the hydrogels prepared in Example 2 and Comparative Example 2, it can be seen from the figure that the storage modulus of the hydrogel prepared in Example 2 is much higher than that of the hydrogel prepared in Comparative Example 2. This shows that the hydrogel prepared by the present invention has high strength, which is a new carrier for the development of...

Embodiment 3

[0042] An aqueous solution of polymer 3 (100 repeating units, 1 mL, 200 mg / mL) and an aqueous solution of N-isopropylamine acrylamide-o-hydroxymethylbenzene borate half ester random copolymer (2 mL, 100 mg / mL, pH=7.5) Quickly stir and mix evenly, and stand still for 30 minutes to obtain a hydrogel.

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Abstract

The invention relates to the technical field of biopolymer, and provides a double-component high-strength hydrogel and a preparation method thereof. The double-component high-strength hydrogel is prepared through mixing a glycopolymer and an N-isopropylamine acrylamide-o-hydroxymethylbenzeneboronic acid half ester random copolymer. The repeating unit of the glycopolymer is galactose connected through 6-site hydroxyl. According to the preparation method, the hydrogel is prepared according to a principle that glycopolymer and o-hydroxymethylbenzeneboronic acid half ester polymer can form dynamic covalent bond. The preparation method is simple to operate. The prepared hydrogel has high strength, and the adopted polymers are easy to synthesize. The hydrogel has glucose responsiveness, and can be used as a controlled release carrier of insulin. Therefore, a novel idea is provided for painless treatments of diabetes.

Description

technical field [0001] The invention belongs to the technical field of biopolymers, and in particular relates to a two-component high-strength hydrogel and a preparation method thereof. Background technique [0002] Polymer hydrogel is a cross-linked three-dimensional network material rich in aqueous solution. It has good biocompatibility and other advantages. Potential application value, the most promising one is the application in drug sustained release. The latest development of a class of polymer hydrogels is the hydrogel based on sugar polymers and o-hydroxymethylphenylboronic acid half-ester polymers, where sugar polymers refer to sugar compounds that are introduced into the polymer through chemical reactions. a polymer. The o-hydroxymethylphenylboronic acid half ester in this kind of hydrogel can form dynamic covalent bonds with the hydroxyl groups on sugar compounds under neutral conditions, and the dynamic covalent bonds can gel under acidic conditions and the pre...

Claims

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Application Information

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IPC IPC(8): C08L5/00C08L33/24C08J3/075A61K9/06A61K47/36A61K47/32
CPCA61K9/06A61K47/32A61K47/36C08J3/075C08J2305/00C08J2333/24C08J2405/00C08J2433/24C08L5/00C08L33/24C08L2205/025C08L2205/03
Inventor 孙鹏飞程鹏范曲立候焕知李金红黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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