Cyanine dye-nanogold SERS probe and preparation method thereof
A cyanine and nano-gold technology, applied in the field of nano-gold SERS probes, achieves good stability and enhanced SERS effect
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Embodiment 1
[0036] Cyanine dye molecule 1,1'-dibutyl-3,3,3',3'-tetramethylindocyanine iodide (C 31 h 41 IN 2 ) Preparation and characterization of 13nm gold SERS probe:
[0037] (1) Preparation of 13nm gold particles:
[0038] 1.7 mL of HAuCl 4The aqueous solution (1%) was mixed with 50 mL of water and heated while stirring until boiling, then 5 mL of sodium citrate solution (1%) was added rapidly, and the reduction reaction continued for 15 minutes. The solution was wine red at the end of the reaction, and was cooled to room temperature to obtain a gold nanoparticle sol with citrate ions on the surface, the particle size was ~13 nm, and the concentration was about 16 nmol / L.
[0039] (2) Surface plasmon characteristics of 13nm gold particles
[0040] figure 1 It is the UV-Vis spectrogram of 13nm gold particles, and it can be clearly observed that the maximum absorption wavelength (λ max ) at 519nm, its particle size corresponds to the 13nm particle size reported in the literature....
Embodiment 2
[0052] Cyanine dye molecule iodide 1,1'-dihexyl-3,3,3',3'-tetramethylindium cyanine (C 35 h 49 IN 2 ) Preparation and characterization of 30nm gold SERS probe:
[0053] (1) Preparation of 30nm gold particles:
[0054] 2.2 mL of HAuCl 4 The aqueous solution (1%) was mixed with 50 mL of water and heated while stirring until boiling, then 6.5 mL of acrylic acid solution (13%) (1%) was added rapidly, and the reduction reaction continued for 15 minutes. The solution was wine red at the end of the reaction, and was cooled to room temperature to obtain a sol of gold nanoparticles carrying acrylate ions on the surface, the particle size was ~30 nm, and the concentration was about 16 nM.
[0055] (2) Surface plasmon characteristics of 30nm gold particles
[0056] Figure 7 It is the UV-Vis spectrogram of 30 nanometer gold particles, and it can be clearly observed that the maximum absorption wavelength (λ max ) at 521nm, its particle size corresponds to the 30nm particle size rep...
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