Surface drug-loaded sustained-release maxillofacial implant percutaneous abutment and preparation method thereof

An abutment and slow-release technology, applied in dental implants, medical science, bone implants, etc., can solve the problem of high failure rate of maxillofacial percutaneous implants, and achieve the goal of resisting the invasion of bacteria and external stimuli on implants, The effect of reducing the failure rate and promoting the formation of biological bonds

Active Publication Date: 2016-09-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, the surface of percutaneous implant abutments for maxillofacial implants at home and abroad is smooth, and the soft tissues of the maxillofacial region cannot form a close biological combin

Method used

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  • Surface drug-loaded sustained-release maxillofacial implant percutaneous abutment and preparation method thereof
  • Surface drug-loaded sustained-release maxillofacial implant percutaneous abutment and preparation method thereof
  • Surface drug-loaded sustained-release maxillofacial implant percutaneous abutment and preparation method thereof

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Embodiment Construction

[0030] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0031] see Figure 4 , the preparation method of the surface drug-loaded slow-release maxillofacial implant percutaneous abutment disclosed by the present invention comprises the following steps:

[0032] (1) Preparation of titanium dioxide nanotube coating

[0033] ①Choose pure titanium and process it into a base body, polish it, clean it ultrasonically with acetone, absolute ethanol and deionized water in sequence, and dry it in vacuum.

[0034] ② Prepare titanium dioxide nanotube coating on the surface of the abutment by anodic oxidation, ultrasonic cleaning, vacuum drying, and radiation sterilization.

[0035] Anodizing method: prepare 1~2mol / L H 3 PO 4 and 0.3% HF mixed electrolyte, placed in an electromagnetic stirrer for continuous stirring. Take the dried abutment and put it into...

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Abstract

The invention discloses a surface drug-loaded sustained-release maxillofacial implant percutaneous abutment and a preparation method thereof, and belongs to the technical field of maxillofacial implant materials. Firstly, a nanotube coating layer is prepared on the surface of an abutment, in addition, mesoporous silica nanoparticles (MSN) are prepared, and the interiors of MSN three-dimensional pore passages are loaded with a connective tissue growth factor (CTGF); then, the MSN loaded with the CTGF is loaded into nanotube passages of the surface of the abutment, a composite sustained-release coating layer is established, and the CTGF is sustained-released for a long term; formation of biological combination between percutaneous part soft tissues and the percutaneous implant abutment is expected to be effectively promoted, so that invasion of bacteria and external stimulation on an implant can be resisted, and the failure rate of the percutaneous implant is reduced. The formation of biological combination between the percutaneous part soft tissues and the percutaneous implant abutment is expected to be effectively promoted, so that invasion of the bacteria and the external stimulation on the implant can be resisted, and the failure rate of the percutaneous implant is reduced.

Description

technical field [0001] The invention belongs to the technical field of maxillofacial implant materials, and in particular relates to a surface-loaded slow-release maxillofacial implant percutaneous abutment and a preparation method thereof. Background technique [0002] Oral craniomaxillofacial implant technology is a high-tech technology to improve the quality of life of patients. Oral craniomaxillofacial implant technology is a technique for repairing oral craniomaxillofacial defects. After surgery, implants that are biocompatible with the human body are implanted in the jawbone of the edentulous part of the human oral cavity or in the bone tissue of the craniofacial defect, as a retainer for wild tooth roots or craniofacial prostheses, and stop the oral cavity. Restoration of dental and craniofacial defects. [0003] At present, a large number of patients with maxillofacial defects need to use prosthesis to restore appearance and physiological function. With the develo...

Claims

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Application Information

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IPC IPC(8): A61C8/00A61F2/28A61L27/22A61L27/02A61L27/06
CPCA61C8/0013A61F2/0077A61F2/2846A61F2/2875A61F2002/2889A61F2002/3006A61F2310/0061A61F2310/00616A61F2310/00976A61L27/025A61L27/06A61L27/227A61L2430/02A61L2430/12C08L89/00
Inventor 魏洪波赵铱民李德华王嘉
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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