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Medicine for treating gastrointestinal pain and preparation method of medicine

A technology of medicine and yam, applied in the field of medicine and its preparation, can solve the problems of lack of patient adjustment, achieve the effect of reducing dosage and retaining active ingredients

Inactive Publication Date: 2016-09-21
李玉宾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the increasing work pressure of modern people, the diet does not pay attention to restraint, and the number of patients with gastrointestinal pain has an increasing trend. When the patient suffers from the onset, the pain is unbearable, and the clinical emergency treatment is mostly pain relief, and the overall adjustment of the patient is lacking.

Method used

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  • Medicine for treating gastrointestinal pain and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0020] Experimental Example 1: Effects on Writhing Reaction of Mice Induced by Acetic Acid

[0021] 1. Reagents

[0022] Dexamethasone Sodium Phosphate Yangzhou Pharmaceutical Co., Ltd.; Glacial Acetic Acid, Xilong Chemical Factory, Shantou, Guangdong; Sodium Carboxymethyl Cellulose, Shanghai Lingfeng Chemical Reagent Co., Ltd.;

[0023] 2. Experimental method:

[0024] A total of 40 Kunming mice, half male and half female, with a body weight of 18-22g, were divided into random groups and gavaged respectively, and the drug administration group was divided into low-dose group and high-dose group (200, 400 mg / kg) and the positive group were given dexamethasone (5mg / kg), and the control group was given the same amount of 0.5% sodium carboxymethylcellulose for 5 consecutive days. 30 minutes after the last administration, intraperitoneally inject 0.7% glacial acetic acid 0.1m1 / 10g, observe and record the number of writhing of the mice within 10 minutes after the injection of the...

Embodiment 1

[0035] 1. Prescription:

[0036] Stir-fry Atractylodes 230g, Codonopsis 200g, Poria cocos 180g, tangerine peel 170g, white peony 120g, qinpi 100g, atractylodes 100g, yam 100g, woody 80g, aconite 40g, forsythia 50g, citrus aurantium 50g, dried ginger 50g, roasted licorice 110g, ginger 100g.

[0037] 2. Preparation method:

[0038] Ginger is squeezed to extract juice; Codonopsis pilosula, Chinese yam, and woody incense are crushed to make medicinal powder; Qinpi and Atractylodes atractylodes are extracted with ethyl acetate: ethanol = 1: 1 as a solvent for reflux for 1 hour to obtain an extract, which is passed through an ODS-C18 column. 30% ethanol as the mobile phase, and then use 90% ethanol as the mobile phase to obtain the eluent, concentrate and dry the eluent, and continue to separate the intermediate product obtained by preparative liquid chromatography; Decoct for 1 hour, decoct for 30 minutes for the second time, combine the medicinal liquid, filter, concentrate, add...

Embodiment 2

[0041] 1. Prescription:

[0042] Stir-fry Atractylodes 220g, Codonopsis 190g, Poria cocos 160g, tangerine peel 150g, white peony 130g, qinpi 110g, atractylodes 110g, yam 90g, woody 90g, aconite 30g, forsythia 40g, citrus aurantium 40g, dried ginger 60g, roasted licorice 100g, ginger 90g.

[0043] 2. Preparation method:

[0044] Ginger is squeezed to extract juice; Codonopsis pilosula, yam, and woody are crushed to make medicinal powder; Qinpi and Atractylodes ethanol are refluxed and extracted for 1 hour to obtain an extract; Minutes, combine the medicinal solution, filter, concentrate to obtain a concentrated solution; add the extract, concentrated solution and ginger juice to the medicinal powder, add appropriate amount of auxiliary materials, mix well, and compress into tablets.

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Abstract

The invention relates to a medicine for treating gastrointestinal pain and a preparation method of the medicine. The medicine is characterized by consisting of the following medicinal raw materials in parts by weight: 190-250 parts of roasted bighead atractylodes rhizome, 160-220 parts of radix codonopsis, 120-190 parts of poria cocos, 120-190 parts of dried orange peel, 80-160 parts of radix paeoniae alba, 60-140 parts of cortex fraxini, 60-140 parts of rhizoma atractylodis, 60-130 parts of rhizoma dioscoreae, 60-110 parts of radix aucklandiae, 10-60 parts of radix aconiti carmichaeli, 20-80 parts of fructus forsythiae, 20-70 parts of fructus aurantii immaturus, 20-80 parts of dried ginger, 30-120 parts of radix glycyrrhizae preparata and 40-140 parts of fresh ginger. The invention also discloses the preparation method of the medicine. The prescription of the medicine disclosed by the invention is mainly used for treating the gastrointestinal pain caused by abdominal pain due to deficiency of yang, affection of exotenous wind-cold or food stagnation.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a medicine for gastrointestinal pain and a preparation method thereof. . Background technique [0002] There are many reasons for gastrointestinal pain, including digestive system inflammation, intestinal mechanical stimulation, psychological stress and other factors. With the increasing work pressure of modern people and the lack of attention to diet, the number of patients with gastrointestinal pain is increasing. When the patient suffers from the onset, the pain is unbearable, and the clinical emergency treatment is mostly pain relief, and the overall adjustment of the patient is lacking. [0003] Our country's traditional Chinese medicine has the characteristics of small side effects and outstanding conditioning function, which can effectively improve the spleen and stomach and other problems. Contents of the invention [0004] The object of the present inven...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/00A61P1/14A61P29/00
CPCA61K36/284A61K36/076A61K36/285A61K36/344A61K36/484A61K36/63A61K36/634A61K36/65A61K36/71A61K36/714A61K36/752A61K36/8945A61K36/9068A61K2236/31A61K2236/33A61K2236/331A61K2236/39A61K2236/55A61K2300/00
Inventor 李玉宾
Owner 李玉宾