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Stem cell composite collagen scaffold kit used for repairing endometrial damage, and preparation method thereof

A technology of endometrium and collagen scaffolds, applied in the field of obstetrics and gynecology, can solve the problems of UC-MSCs repairing endometrial damage research reports, etc., and achieve the effect of protecting the welfare of experimental animals, good safety, and promoting cell differentiation

Inactive Publication Date: 2016-10-05
NANJING DRUM TOWER HOSPITAL
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  • Abstract
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  • Claims
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Problems solved by technology

[0006] Before the present invention, there was no relevant research report on UC-MSCs repairing endometrial damage

Method used

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  • Stem cell composite collagen scaffold kit used for repairing endometrial damage, and preparation method thereof
  • Stem cell composite collagen scaffold kit used for repairing endometrial damage, and preparation method thereof
  • Stem cell composite collagen scaffold kit used for repairing endometrial damage, and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment

[0034] The stem cell composite collagen scaffold kit for repairing endometrial damage consists of human umbilical cord mesenchymal stem cells and collagen scaffolds.

[0035] Human umbilical cord mesenchymal stem cells were isolated and cultured from the stem cell bank of the Institute of Genetics, Chinese Academy of Sciences. Cell surface antigen identification by flow cytometry showed that CD14, CD34, and CD45 were negative, and CD29, CD44, and CD105 were positive, showing that they were mesenchymal stem cells. feature.

[0036] The collagen scaffold is provided by Yantai Zhenghai Biotechnology Co., Ltd., and has been approved by SFDA for skin and oral mucosa repair.

[0037] Severe endometrial injury refers to excessive endometrial injury caused by various reasons, endometrial functional repair disorder, replaced by connective tissue hyperplasia and repair, uterine wall fibrosis, and scar formation.

[0038] The preparation method of the above-mentioned stem cell composite...

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Abstract

The invention provides a stem cell composite collagen scaffold kit for repairing endometrial damage and a preparation method thereof, which consists of human umbilical cord mesenchymal stem cells and collagen scaffolds. The preparation method comprises the steps of recovery of umbilical cord mesenchymal stem cells, passage of umbilical cord mesenchymal stem cells, and compound culture of umbilical cord mesenchymal stem cells and collagen scaffolds. The kit of the present invention uses collagen scaffolds for umbilical cord mesenchymal stem cells to repair the endometrium, and has the following advantages compared with traditional endometrial repair methods: the presence of collagen scaffolds can provide attachment sites for umbilical cord mesenchymal stem cells to position them In the damaged part of the intima, it is conducive to local tissue repair, improves the effectiveness of repair and reduces the risk of cell translocation; at the same time, the collagen scaffold can promote cell differentiation.

Description

technical field [0001] The invention belongs to the field of obstetrics and gynecology, and specifically designs a stem cell composite collagen scaffold kit for repairing endometrial damage and a preparation method thereof. Background technique [0002] When the endometrium is severely damaged, the functional repair of the endometrium is impaired, replaced by connective tissue hyperplasia and repair, fibrosis of the anterior and posterior walls of the uterus, and scar formation. Clinically, the main manifestations are intrauterine adhesions, amenorrhea, and uterine infertility. How to rebuild the intima of these patients and restore their normal shape and function is one of the difficult problems in regenerative medicine today. In the process of research, scholars have proposed a variety of different treatment methods, such as the use of intrauterine device, balloon catheter, estrogen or hyaluronic acid application after adhesion separation, etc., each treatment method has i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/38
Inventor 胡娅莉薛白曹昀颜桂军戴建武
Owner NANJING DRUM TOWER HOSPITAL
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