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Extraction process of chlortetracycline premixed agent

An extraction process, the technology of chlortetracycline, applied in the field of extraction process of high-content chlortetracycline premix, can solve the problems of low content of biologically active components, increased sewage treatment costs, high potency of chlortetracycline, etc., to achieve increased yield High efficiency, reduced sewage treatment cost, and simple production process

Inactive Publication Date: 2016-10-12
PUCHENG CHIA TAI BIOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, because calcium carbonate is insoluble in water, and the mixed solution after adding calcium carbonate is weakly acidic or neutral, it cannot be better combined with aureomycin dissolved in the fermentation broth to form a salt and precipitate, so that residual aureomycin remains in the filtrate. The potency of the element is high, resulting in a low extraction rate and an increase in the cost of sewage treatment
And the content of biologically active ingredients in the premix obtained by adding calcium carbonate is low, which cannot meet the needs of customers for products with high biologically active ingredient content

Method used

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  • Extraction process of chlortetracycline premixed agent
  • Extraction process of chlortetracycline premixed agent
  • Extraction process of chlortetracycline premixed agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment one, get aureomycin and put tank fermented liquid 90m 3 , divided into 2 equal volumes.

[0038] One group: take one part of aureomycin and put it in a tank for 45m fermentation liquid 3 , use the calculation formula to calculate the amount of calcium oxide added, add calcium oxide under normal temperature conditions, the pH of the fermentation treatment solution is 7.8, stir for 30 minutes, and the speed is 60-80 r / min to obtain the calcification complex solution; the calcification complex solution Plate and frame filtration, the pressure is controlled at 0.5-0.75Mpa; the filter cake obtained after filtration is crushed; the crushed particles are boiled and dried, the inlet temperature is controlled at 150-160°C, and the outlet temperature is 50-70°C to obtain aureomycin Finished premix.

[0039]One group of control group: take another aureomycin and put the fermented liquid in a tank for 45m 3 , directly add calcium carbonate equivalent to 5% of the volu...

Embodiment 2

[0040] Embodiment two, get aureomycin and put tank fermented liquid 89m 3 , divided into 2 equal volumes.

[0041] The second group: take one part of aureomycin and put it in a tank to ferment 44.5m 3 , Calculate the amount of calcium oxide added with the calculation formula, add calcium oxide under normal temperature conditions, the pH of the fermentation treatment solution is 8.5, and the other extraction processes are the same as the first group.

[0042] Two groups of control groups: take another chlortetracycline and put the fermentation liquid in a tank of 44.5m 3 , directly add calcium carbonate equivalent to 5% of the volume of the fermentation broth at room temperature, and other extraction processes are the same as a group of control groups.

Embodiment 3

[0043] Embodiment three, get aureomycin and put tank fermented liquid 91m 3 , divided into 2 equal volumes.

[0044] Three groups: take one part of aureomycin and put it in a tank for 45.5m fermentation broth 3 , Calculate the amount of calcium oxide added with the calculation formula, add calcium oxide under normal temperature conditions, the pH of the fermentation treatment solution is 9.0, and the other extraction processes are the same as the first group.

[0045] Three groups of control groups: take another 45.5m 3 , directly add calcium carbonate equivalent to 6% of the volume of the fermentation broth at room temperature, and other extraction processes are the same as a group of control groups.

[0046] The test results obtained by the three examples are shown in Table 2.

[0047]

[0048] As can be seen from the above implementation comparison, the present invention improves the production process, and calcium oxide can be used as a pH regulator to make the ferme...

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Abstract

The present invention discloses an extraction process of a chlortetracycline premixed agent. The process includes seed cultivation, fermentation cultivation and product refining. The product refining includes: taking a chlortetracycline fermentation liquid, adding calcium oxide; controlling the pH value of the fermentation liquid at 7.8 to 9.5, conducting complexation stirring under normal temperature for 30min at the speed of 60-80 r / min to obtain a calcification complexing liquid; and conducting plate filtration and boiling drying to obtain a finished chlortetracycline premixed agent. The extraction process can improve the quality, content and yield of the chlortetracycline premixed agent and reduce the production cost.

Description

technical field [0001] The invention relates to an antibiotic preparation process, in particular to an extraction process of a high-content chlortetracycline premix. Background technique [0002] At present, chlortetracycline products mainly include two types of chlortetracycline premix and chlortetracycline hydrochloride. Chlortetracycline hydrochloride is widely accepted because of its complex extraction process and the need for large workshops and high equipment investment. limit. There are also great uncertainties in the extraction process of aureomycin premix, which also leads to large differences in content (biological potency) and yield between product batches. Especially the customer's demand for aureomycin premix products with high content of bioactive ingredients. [0003] Invention patent (CN 102899377 A) discloses a preparation method of chlortetracycline premix. During extraction, calcium carbonate equivalent to 0-12% of the volume of the fermentation broth is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P29/00C07C231/24C07C237/26C12R1/49
CPCC12P29/00C07C231/24C07C237/26
Inventor 吴新芝冯献毛红卫徐文雪许意锋章辉
Owner PUCHENG CHIA TAI BIOCHEM
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