Quality control method of raw astragalus membranaceus wasting-thirst capsules

A quality control method and technology for quenching thirst with stilbene, which can be used in measuring devices, instruments, scientific instruments, etc., to solve the problems of single index component, incomplete feature identification, and poor content determination specificity, so as to ensure stability and improve product quality. The technical level and the effect of improving quality standards

Inactive Publication Date: 2016-10-12
GUIZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The purpose of the present invention is to provide a quality control method for Shengqi Xiaoke Capsules, so as to solve the problems in the existing quality control methods for Shengqi Xiaoke Capsules such as single index components, incomplete feature identification, poor specificity of content determination, etc. So as to be able to scientifically evaluate the quality of Shengqi Xiaoke Capsules

Method used

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  • Quality control method of raw astragalus membranaceus wasting-thirst capsules
  • Quality control method of raw astragalus membranaceus wasting-thirst capsules
  • Quality control method of raw astragalus membranaceus wasting-thirst capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Qualitative Identification of Rehmannia glutinosa in Shengqi Xiaoke Capsules

[0017] 1.1 Instrument

[0018] DK-98-11 constant temperature water bath (Tianjin Test Instrument Co., Ltd.), ultrapure water machine (SC-080160, Sichuan Wotel Technology Development Co., Ltd.), electronic balance (METTLER AE-240, Mettler- Toledo Instrument Shanghai Co., Ltd.), electric heating constant temperature blast drying oven (Shanghai Boxun Co., Ltd. Medical Equipment Factory).

[0019] 1.2 Reagents and reagents

[0020] Catalpol reference substance (Sichuan Weikeqi Biotechnology Co., Ltd., batch number 141104, purity ≥ 98%), anisaldehyde (Sinopharm Chemical Reagent Co., Ltd., batch number 20150312), silica gel G plate (200×200 mm, Qingdao Ocean Chemical Co., Ltd. Branch plant), Methanol (Shanghai Zhenxing Chemical Plant No.1, analytically pure), n-Butanol (Shanghai Zhenxing Chemical No.1 Plant, analytically pure).

[0021] 1.3 Preparation of solution

[0022] 1.3.1 Prep...

Embodiment 2

[0032] Example 2: Determination of 6 main components in Shengqi Xiaoke Capsules

[0033] 2.1 Experimental Instruments

[0034] Agilent 1290 Infinity UHPLC, American Agilent, including autosampler, binary pump, DAD diode array detector, column thermostat; TGL-16G high-speed centrifuge (Shanghai Anting Scientific Instrument Factory); AE240 1 / 100,000 electronic Balance (Mettler-Toledo Instruments Shanghai Co., Ltd.); ultrapure water machine (Sichuan Votel Technology Development Co., Ltd.); DK-98-11 constant temperature water bath (Tianjin Tester Instrument Co., Ltd.); EL2.04 million One-fifth electronic balance (Mettler-Toledo Instrument Shanghai Co., Ltd.); CQ250A-TS ultrasonic cleaning machine (Shanghai Yuejin Medical Optical Instrument Factory).

[0035] 2.2 Experimental reagents and reagents

[0036] Calycosin glucoside reference substance, salvianolic acid B reference substance, salvianolic acid A reference substance, danshensu sodium reference substance, rosmarinic acid r...

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Abstract

The invention discloses a quality control method of Shengqi Xiaoke Capsules, which uses thin-layer chromatography (TLC) to qualitatively identify rehmannia glutinosa in Shengqi Xiaoke Capsules and uses ultra-high performance liquid chromatography (UHPLC) to identify the quality of Shengqi Xiaoke capsules. The contents of acteosin glucoside, salvianolic acid B, salvianolic acid A, danshensu sodium, rosmarinic acid and protocatechualdehyde in Qixiaoke capsules were determined, so that the quality of Shengqixiaoke capsules could be more scientifically evaluated , to ensure the stability of its quality, and to improve the technical level of the product, so as to realize the comprehensive improvement of the quality standard of Shengqi Xiaoke Capsules by using modern analytical methods.

Description

technical field [0001] The invention relates to a quality control method of a traditional Chinese medicine preparation for treating diabetes, belonging to the technical field of medicines. Background technique [0002] Shengqi Xiaoke Capsule is a traditional Chinese medicine compound preparation made of three medicinal flavors of astragalus, rehmannia glutinosa and salvia miltiorrhiza. It has the effects of nourishing qi and promoting body fluid, promoting blood circulation and removing stasis. It is mainly suitable for patients with type 2 diabetes mellitus for symptoms such as fatigue, eating too much and getting hungry easily, thirsty and drinking a lot, and urinating too much. It has been clinically used for many years and has a definite curative effect. [0003] The current quality standard of Shengqi Xiaoke Capsules is relatively simple. Only the TLC identification and extract inspection of astragaloside IV in Astragalus membranaceus are carried out, while the content ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
CPCG01N30/90G01N30/02G01N2030/027
Inventor 郭兵王永林李勇军黄勇王爱民兰燕宇郑林陆苑
Owner GUIZHOU MEDICAL UNIV
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