A preparing method of a radix notoginseng total saponin transdermal agent
The technology of total saponins of Panax notoginseng and transdermal agent is applied in the field of preparation of transdermal agent, which can solve the problems of inconvenient clinical administration of liquid preparations, limited utilization and the like, and achieves the effects of improving immunity of the body, relieving local symptoms, and quick effect.
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Embodiment 1
[0028] A panax notoginseng total saponin transdermal agent mainly contains notoginseng total saponin, and the encapsulation rate is 86.79±1.68%.
[0029] The preparation method of the aforementioned panax notoginseng saponins transdermal agent, the specific preparation steps are as follows:
[0030] (1) The total saponins of Panax notoginseng are superfinely crushed and passed through a 200-mesh sieve;
[0031] (2) Weigh 25g of panax notoginseng saponins as raw materials;
[0032] (3) Add the panax notoginseng saponins to 1L of absolute ethanol, magnetically stir for 6 hours in a sealed explosion-proof environment at room temperature;
[0033] (4) Put the solution obtained in step (3) into distilled water with a V / V of 16:1, stir for 30 minutes, and set aside;
[0034] (5) Dissolve 1 g of chitosan in 32 mL of 1% glacial acetic acid solution, stir and dissolve the chitosan glacial acetic acid solution, where the stirring temperature is 45-55°C, and the heating method is steam heating;
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Embodiment 2
[0044] A panax notoginseng total saponin transdermal agent mainly contains notoginseng total saponin, and the encapsulation rate is 84.89±1.79%.
[0045] The preparation method of the aforementioned panax notoginseng saponins transdermal agent, the specific preparation steps are as follows:
[0046] (1) The total saponins of Panax notoginseng are superfinely pulverized and passed through a 300-mesh sieve;
[0047] (2) Weigh 30g of panax notoginseng saponins as raw materials;
[0048] (3) Add the panax notoginseng saponins to 1L of absolute ethanol, magnetically stir for 6 hours in a sealed explosion-proof environment at room temperature;
[0049] (4) Put the solution obtained in step (3) into distilled water with a V / V of 16:1, stir for 30 minutes, and set aside;
[0050] (5) Dissolve 7.5 g of chitosan in 160 mL of 2% glacial acetic acid, stir to dissolve the chitosan glacial acetic acid solution, the stirring temperature is 45° C., and the heating method is steam heating.
[0051] (6) Di...
Embodiment 3
[0060] A panax notoginseng total saponin transdermal agent mainly contains notoginseng total saponin, and the encapsulation rate is 81.89±1.33%.
[0061] The preparation method of the aforementioned panax notoginseng saponins transdermal agent, the specific preparation steps are as follows:
[0062] (1) The total saponins of Panax notoginseng are superfinely crushed and passed through a 100-mesh sieve;
[0063] (2) Weigh 28g of panax notoginseng saponins as raw materials;
[0064] (3) Add the panax notoginseng saponins to 1L of absolute ethanol, magnetically stir for 6 hours in a sealed explosion-proof environment at room temperature;
[0065] (4) Put the solution obtained in step (3) into distilled water with a V / V of 16:1, stir for 30 minutes, and set aside;
[0066] (5) Dissolve 1.8 g of chitosan in 32 mL of 3% glacial acetic acid, stir to dissolve the chitosan glacial acetic acid solution, the stirring temperature is 55° C., and the heating method is steam heating.
[0067] (6) Dissol...
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