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A method of preparing allium mongolicum total flavonoids and applications of the total flavonoids

The technology of total flavonoids and shallots is applied in the field of preparation of total flavonoids of shallots, which can solve the problems of high dosage of drugs, drug resistance and the like, and achieve the effects of simple process, long shelf life and low cost.

Inactive Publication Date: 2016-10-26
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the applicable antihypertensive drugs are more expensive, especially western medicines are likely to cause obvious drug resistance, resulting in patients becoming more and more dependent on drugs, and the amount of drugs taken is also increasing

Method used

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  • A method of preparing allium mongolicum total flavonoids and applications of the total flavonoids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dry and pulverize the shallot in the shade; place the powder of the shallot in an ultrasonic extraction device with a frequency of 20KHz, add 70% ethanol solution 6 times the weight of the raw material, set the ultrasonic temperature to 60°C, and the time to 2h, filter, and repeat the extraction of the filter residue 2 times, combine the filtrates; concentrate the resulting filtrate until it has no alcohol smell, transfer it to an 80-mesh polyamide resin column with a diameter-to-height ratio of 1:4, first elute with 2 times the column volume of distilled water, and then use 4 times the column volume 70% ethanol was used for elution, and the eluate was collected; the eluate was concentrated and dried to obtain the total flavonoids of Shallot, and the content of total flavonoids was 63.4% by UV detection.

Embodiment 2

[0026] Dry and crush the shallots in the shade; put the shallot powder in an ultrasonic extraction device with a frequency of 20KHz, add 75% ethanol solution 7 times the weight of the raw materials, set the ultrasonic temperature to 70°C, and the time to 3h, filter, and repeat the extraction of the filter residue 2 times, the filtrates were combined; the resulting filtrate was concentrated until it had no alcohol smell, and transferred to an 80-mesh polyamide resin column with a diameter-to-height ratio of 1:6. The 75% ethanol was used for elution, and the eluate was collected; the eluate was concentrated and dried to obtain the total flavonoids of Shallot, and the content of the total flavonoids was 77.8% by UV detection.

Embodiment 3

[0028] Dry and pulverize the shallots in the shade; place the shallot powder in an ultrasonic extraction device with a frequency of 20KHz, add 80% ethanol solution that is 8 times the weight of the raw material, set the ultrasonic temperature to 65°C, and the time to 3h, filter, and repeat the extraction of the filter residue 2 times, the filtrates were combined; the resulting filtrate was concentrated until there was no alcohol smell, and transferred to an 80-mesh polyamide resin column with a diameter-to-height ratio of 1:5. The 80% ethanol was used for elution, and the eluate was collected; the eluate was concentrated and dried to obtain the total flavonoids of Shallot, and the content of the total flavonoids was 59.6% by UV detection.

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Abstract

A method of preparing allium mongolicum total flavonoids and applications of the total flavonoids are disclosed. The method includes (1) drying allium mongolicum in the shade and crushing, (2) extracting with ultrasonic waves, (3) purifying with polyamide resin, eluting with ethanol and collecting an eluate, and (4) concentrating and drying to obtain the total flavonoids. Animal experiments prove that the total flavonoids have good functions of lowering the blood pressure and can be widely used for preparing medicines reducing the blood pressure.

Description

technical field [0001] The invention specifically relates to a preparation method and application of total flavonoids of shallot. Background technique [0002] Flavonoids are secondary metabolites that widely exist in plants, and are one of the main active ingredients in medicinal plants. The diversity of their structure types and the broad spectrum of biological activities have been the focus of research and development at home and abroad in recent years. . Existing studies have shown that it has significant medicinal and health functions such as anti-oxidation, scavenging free radicals, anti-aging, anti-mutation, lowering blood fat, lowering blood pressure, etc., and because of its high efficiency and safety, it can also be used as a natural additive for food and cosmetics , has broad development prospects. [0003] At present, the research on the total flavonoids of scallion mainly focuses on its chemical constituents, but less on its pharmacology. Hypertension is a ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P9/12
CPCA61K36/8962A61K2236/333A61K2236/39A61K2236/55
Inventor 杨成东
Owner NANJING ZELANG MEDICAL TECH
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